Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032578412> ?p ?o ?g. }
- W2032578412 endingPage "326" @default.
- W2032578412 startingPage "319" @default.
- W2032578412 abstract "Hepatitis C virus (HCV) is associated with B-cell disorders, including mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). We hypothesized that combination of serum biomarkers could be used to identify B-NHL in HCV patients. We measured in 155 HCV infected patients, with and without MC and/or B-NHL, serum levels of eight markers previously described to be increased in patients with B-NHL, i.e. sCD22, sCD27, sIL-2Rα, sCD137, free-light chains of Ig (ratio κ/λ), heavy chains of Ig (ratio IgMκ/IgMλ), gammaglobulins and C4. We used a multiparametric analysis to determine a signature that identifies patients with overt B-NHL. Serum levels were significantly different between patients without MC, patients with asymptomatic MC, patients with MC vasculitis and those with MC vasculitis and B-NHL for all biomarkers except for sCD137. Using multiparametric analysis, we identified a signature involving sCD27, sIL-2Rα, gammaglobulins and C4 levels associated with the presence of overt B-NHL in HCV-infected patients. This signature had a sensitivity of 100%, a specificity of 90%, and positive and negative predictive values of 97 and 100%, respectively for discriminating patients with overt B-NHL and those without B-NHL. Our data indicate that serum biomarker signature allows identifying HCV-infected patients presenting with overt B-NHL." @default.
- W2032578412 created "2016-06-24" @default.
- W2032578412 creator A5000680638 @default.
- W2032578412 creator A5002774188 @default.
- W2032578412 creator A5007113478 @default.
- W2032578412 creator A5010707925 @default.
- W2032578412 creator A5014570473 @default.
- W2032578412 creator A5018835683 @default.
- W2032578412 creator A5039850863 @default.
- W2032578412 creator A5044456322 @default.
- W2032578412 creator A5049022185 @default.
- W2032578412 creator A5063466256 @default.
- W2032578412 creator A5085912537 @default.
- W2032578412 date "2014-03-01" @default.
- W2032578412 modified "2023-09-29" @default.
- W2032578412 title "Serum biomarker signature identifies patients with B-cell non-Hodgkin lymphoma associated with cryoglobulinemia vasculitis in chronic HCV infection" @default.
- W2032578412 cites W1969296561 @default.
- W2032578412 cites W1974763163 @default.
- W2032578412 cites W1978770080 @default.
- W2032578412 cites W1979638645 @default.
- W2032578412 cites W1982644308 @default.
- W2032578412 cites W1995624813 @default.
- W2032578412 cites W2001679455 @default.
- W2032578412 cites W2002041623 @default.
- W2032578412 cites W2003036666 @default.
- W2032578412 cites W2011345683 @default.
- W2032578412 cites W2027155525 @default.
- W2032578412 cites W2031985577 @default.
- W2032578412 cites W2040808943 @default.
- W2032578412 cites W2044713055 @default.
- W2032578412 cites W2050860711 @default.
- W2032578412 cites W2057102838 @default.
- W2032578412 cites W2060498412 @default.
- W2032578412 cites W2108302171 @default.
- W2032578412 cites W2115968797 @default.
- W2032578412 cites W2116338391 @default.
- W2032578412 cites W2117291755 @default.
- W2032578412 cites W2125975315 @default.
- W2032578412 cites W2129468034 @default.
- W2032578412 cites W2136247884 @default.
- W2032578412 cites W2144513130 @default.
- W2032578412 cites W2150709430 @default.
- W2032578412 cites W2150990886 @default.
- W2032578412 cites W2167150786 @default.
- W2032578412 cites W2170811222 @default.
- W2032578412 cites W2317111303 @default.
- W2032578412 cites W2338264038 @default.
- W2032578412 cites W2340570947 @default.
- W2032578412 cites W43418532 @default.
- W2032578412 doi "https://doi.org/10.1016/j.autrev.2013.11.001" @default.
- W2032578412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24220267" @default.
- W2032578412 hasPublicationYear "2014" @default.
- W2032578412 type Work @default.
- W2032578412 sameAs 2032578412 @default.
- W2032578412 citedByCount "20" @default.
- W2032578412 countsByYear W20325784122015 @default.
- W2032578412 countsByYear W20325784122016 @default.
- W2032578412 countsByYear W20325784122018 @default.
- W2032578412 countsByYear W20325784122019 @default.
- W2032578412 countsByYear W20325784122020 @default.
- W2032578412 countsByYear W20325784122021 @default.
- W2032578412 countsByYear W20325784122022 @default.
- W2032578412 countsByYear W20325784122023 @default.
- W2032578412 crossrefType "journal-article" @default.
- W2032578412 hasAuthorship W2032578412A5000680638 @default.
- W2032578412 hasAuthorship W2032578412A5002774188 @default.
- W2032578412 hasAuthorship W2032578412A5007113478 @default.
- W2032578412 hasAuthorship W2032578412A5010707925 @default.
- W2032578412 hasAuthorship W2032578412A5014570473 @default.
- W2032578412 hasAuthorship W2032578412A5018835683 @default.
- W2032578412 hasAuthorship W2032578412A5039850863 @default.
- W2032578412 hasAuthorship W2032578412A5044456322 @default.
- W2032578412 hasAuthorship W2032578412A5049022185 @default.
- W2032578412 hasAuthorship W2032578412A5063466256 @default.
- W2032578412 hasAuthorship W2032578412A5085912537 @default.
- W2032578412 hasConcept C126322002 @default.
- W2032578412 hasConcept C159654299 @default.
- W2032578412 hasConcept C203014093 @default.
- W2032578412 hasConcept C2522874641 @default.
- W2032578412 hasConcept C2776015282 @default.
- W2032578412 hasConcept C2776408679 @default.
- W2032578412 hasConcept C2778453870 @default.
- W2032578412 hasConcept C2778922544 @default.
- W2032578412 hasConcept C2779134260 @default.
- W2032578412 hasConcept C2779338263 @default.
- W2032578412 hasConcept C2781197716 @default.
- W2032578412 hasConcept C55493867 @default.
- W2032578412 hasConcept C71924100 @default.
- W2032578412 hasConcept C86803240 @default.
- W2032578412 hasConcept C90924648 @default.
- W2032578412 hasConceptScore W2032578412C126322002 @default.
- W2032578412 hasConceptScore W2032578412C159654299 @default.
- W2032578412 hasConceptScore W2032578412C203014093 @default.
- W2032578412 hasConceptScore W2032578412C2522874641 @default.
- W2032578412 hasConceptScore W2032578412C2776015282 @default.
- W2032578412 hasConceptScore W2032578412C2776408679 @default.
- W2032578412 hasConceptScore W2032578412C2778453870 @default.
- W2032578412 hasConceptScore W2032578412C2778922544 @default.