Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032579873> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2032579873 endingPage "1711" @default.
- W2032579873 startingPage "1704" @default.
- W2032579873 abstract "Previous studies have shown that (R)-(+)-hyoscyamine has analgesic activity as a consequence of increased ACh release following antagonism of central muscarinic autoreceptors. Since the enhancement of central cholinergic transmission could be beneficial for cognitive disorders, we manipulated (R)-(+)-hyoscyamine, synthesizing several derivatives of tropic and 2-phenylpropionic acids, with the aim of obtaining drugs which are able to increase ACh release and consequently to show analgesic and nootropic activities. The results showed that several new compounds are indeed potent analgesics (with an analgesic efficacy comparable to that of morphine) and that the most potent one ((+/-)-19, PG9) also has remarkable cognition-enhancing properties. Our study confirmed that the mechanism of action involves ACh release even if it is still unclear whether only muscarinic autoreceptors or, also, heteroreceptors are involved." @default.
- W2032579873 created "2016-06-24" @default.
- W2032579873 creator A5007182721 @default.
- W2032579873 creator A5015679752 @default.
- W2032579873 creator A5017358008 @default.
- W2032579873 creator A5038441471 @default.
- W2032579873 creator A5044635551 @default.
- W2032579873 creator A5046381036 @default.
- W2032579873 creator A5050177206 @default.
- W2032579873 creator A5059510963 @default.
- W2032579873 creator A5070385506 @default.
- W2032579873 creator A5072590320 @default.
- W2032579873 creator A5078496021 @default.
- W2032579873 creator A5083694119 @default.
- W2032579873 date "1994-05-01" @default.
- W2032579873 modified "2023-10-18" @default.
- W2032579873 title "Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters" @default.
- W2032579873 doi "https://doi.org/10.1021/jm00037a022" @default.
- W2032579873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8201605" @default.
- W2032579873 hasPublicationYear "1994" @default.
- W2032579873 type Work @default.
- W2032579873 sameAs 2032579873 @default.
- W2032579873 citedByCount "30" @default.
- W2032579873 countsByYear W20325798732014 @default.
- W2032579873 countsByYear W20325798732015 @default.
- W2032579873 countsByYear W20325798732017 @default.
- W2032579873 countsByYear W20325798732018 @default.
- W2032579873 countsByYear W20325798732022 @default.
- W2032579873 countsByYear W20325798732023 @default.
- W2032579873 crossrefType "journal-article" @default.
- W2032579873 hasAuthorship W2032579873A5007182721 @default.
- W2032579873 hasAuthorship W2032579873A5015679752 @default.
- W2032579873 hasAuthorship W2032579873A5017358008 @default.
- W2032579873 hasAuthorship W2032579873A5038441471 @default.
- W2032579873 hasAuthorship W2032579873A5044635551 @default.
- W2032579873 hasAuthorship W2032579873A5046381036 @default.
- W2032579873 hasAuthorship W2032579873A5050177206 @default.
- W2032579873 hasAuthorship W2032579873A5059510963 @default.
- W2032579873 hasAuthorship W2032579873A5070385506 @default.
- W2032579873 hasAuthorship W2032579873A5072590320 @default.
- W2032579873 hasAuthorship W2032579873A5078496021 @default.
- W2032579873 hasAuthorship W2032579873A5083694119 @default.
- W2032579873 hasConcept C15744967 @default.
- W2032579873 hasConcept C169760540 @default.
- W2032579873 hasConcept C170493617 @default.
- W2032579873 hasConcept C185592680 @default.
- W2032579873 hasConcept C188987157 @default.
- W2032579873 hasConcept C22885893 @default.
- W2032579873 hasConcept C2775910092 @default.
- W2032579873 hasConcept C2776239663 @default.
- W2032579873 hasConcept C2777383412 @default.
- W2032579873 hasConcept C2778938600 @default.
- W2032579873 hasConcept C2780820201 @default.
- W2032579873 hasConcept C33789571 @default.
- W2032579873 hasConcept C55493867 @default.
- W2032579873 hasConcept C71924100 @default.
- W2032579873 hasConcept C8439214 @default.
- W2032579873 hasConcept C98274493 @default.
- W2032579873 hasConceptScore W2032579873C15744967 @default.
- W2032579873 hasConceptScore W2032579873C169760540 @default.
- W2032579873 hasConceptScore W2032579873C170493617 @default.
- W2032579873 hasConceptScore W2032579873C185592680 @default.
- W2032579873 hasConceptScore W2032579873C188987157 @default.
- W2032579873 hasConceptScore W2032579873C22885893 @default.
- W2032579873 hasConceptScore W2032579873C2775910092 @default.
- W2032579873 hasConceptScore W2032579873C2776239663 @default.
- W2032579873 hasConceptScore W2032579873C2777383412 @default.
- W2032579873 hasConceptScore W2032579873C2778938600 @default.
- W2032579873 hasConceptScore W2032579873C2780820201 @default.
- W2032579873 hasConceptScore W2032579873C33789571 @default.
- W2032579873 hasConceptScore W2032579873C55493867 @default.
- W2032579873 hasConceptScore W2032579873C71924100 @default.
- W2032579873 hasConceptScore W2032579873C8439214 @default.
- W2032579873 hasConceptScore W2032579873C98274493 @default.
- W2032579873 hasIssue "11" @default.
- W2032579873 hasLocation W20325798731 @default.
- W2032579873 hasLocation W20325798732 @default.
- W2032579873 hasOpenAccess W2032579873 @default.
- W2032579873 hasPrimaryLocation W20325798731 @default.
- W2032579873 hasRelatedWork W1885050361 @default.
- W2032579873 hasRelatedWork W1979055604 @default.
- W2032579873 hasRelatedWork W1999400195 @default.
- W2032579873 hasRelatedWork W2000490546 @default.
- W2032579873 hasRelatedWork W2033828867 @default.
- W2032579873 hasRelatedWork W2046592054 @default.
- W2032579873 hasRelatedWork W2052918917 @default.
- W2032579873 hasRelatedWork W2329805498 @default.
- W2032579873 hasRelatedWork W2392494443 @default.
- W2032579873 hasRelatedWork W2409742939 @default.
- W2032579873 hasVolume "37" @default.
- W2032579873 isParatext "false" @default.
- W2032579873 isRetracted "false" @default.
- W2032579873 magId "2032579873" @default.
- W2032579873 workType "article" @default.