Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032582014> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2032582014 endingPage "8634" @default.
- W2032582014 startingPage "8628" @default.
- W2032582014 abstract "Abstract Cancer chemotherapeutic drugs induce apoptosis by several pathways. Inactivation of proapoptotic genes, or activation of survival signaling, leads to chemoresistance. Activator protein 2α (AP-2α), a developmentally regulated sequence-specific DNA-binding transcription factor, has been shown to function like a tumor suppressor. Here, we show that controlled expression of AP-2α, using tetracycline-inducible system, increased the chemosensitivity of cancer cells by severalfold by sensitizing cells to undergo apoptosis upon chemotherapy. Under these conditions, neither AP-2α expression nor drug treatment resulted in apoptosis induction, whereas in combination the cancer cells underwent massive apoptosis. We found that endogenous AP-2α protein is induced posttranscriptionally by various chemotherapeutic drugs. Blocking the endogenous AP-2α by small interfering RNA in human cancer cells lead to decreased apoptosis, increased colony formation, and chemoresistance irrespective of their p53 status upon chemotherapy. We further show that 5-aza-2′-deoxycytidine induced reexpression of AP-2α in MDA-MB-231 breast cancer cells (wherein AP-2α expression is silenced by hypermethylation), resulted in massive apoptosis induction, increased chemosensitivity, decreased colony formation, and loss of tumorigenesis upon chemotherapy. However, in MDA-MB-231 cells transfected with AP-2α small interfering RNA, 5-aza-2′-deoxycytidine treatment failed to increase apoptosis and chemosensitivity. The treatment also resulted in increased colony formation and efficient tumor formation upon chemotherapy. These results establish an important role for AP-2α in cancer cell chemosensitivity and provide new insights for modifying the chemosensitivity of cancer cells by activating apoptotic pathways." @default.
- W2032582014 created "2016-06-24" @default.
- W2032582014 creator A5017090711 @default.
- W2032582014 creator A5039699766 @default.
- W2032582014 creator A5089447078 @default.
- W2032582014 date "2005-10-01" @default.
- W2032582014 modified "2023-09-23" @default.
- W2032582014 title "Activator Protein 2α Status Determines the Chemosensitivity of Cancer Cells: Implications in Cancer Chemotherapy" @default.
- W2032582014 cites W1970260762 @default.
- W2032582014 cites W1984253873 @default.
- W2032582014 cites W1993214904 @default.
- W2032582014 cites W1997791083 @default.
- W2032582014 cites W2004740605 @default.
- W2032582014 cites W2021469012 @default.
- W2032582014 cites W2024464498 @default.
- W2032582014 cites W2024919800 @default.
- W2032582014 cites W2029506276 @default.
- W2032582014 cites W2030954212 @default.
- W2032582014 cites W2031892291 @default.
- W2032582014 cites W2038883360 @default.
- W2032582014 cites W2071804523 @default.
- W2032582014 cites W2079863819 @default.
- W2032582014 cites W2081928213 @default.
- W2032582014 cites W2082512342 @default.
- W2032582014 cites W2091052038 @default.
- W2032582014 cites W2129904436 @default.
- W2032582014 doi "https://doi.org/10.1158/0008-5472.can-05-1059" @default.
- W2032582014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16204029" @default.
- W2032582014 hasPublicationYear "2005" @default.
- W2032582014 type Work @default.
- W2032582014 sameAs 2032582014 @default.
- W2032582014 citedByCount "32" @default.
- W2032582014 countsByYear W20325820142012 @default.
- W2032582014 countsByYear W20325820142013 @default.
- W2032582014 countsByYear W20325820142015 @default.
- W2032582014 countsByYear W20325820142016 @default.
- W2032582014 countsByYear W20325820142017 @default.
- W2032582014 countsByYear W20325820142018 @default.
- W2032582014 countsByYear W20325820142019 @default.
- W2032582014 countsByYear W20325820142021 @default.
- W2032582014 countsByYear W20325820142023 @default.
- W2032582014 crossrefType "journal-article" @default.
- W2032582014 hasAuthorship W2032582014A5017090711 @default.
- W2032582014 hasAuthorship W2032582014A5039699766 @default.
- W2032582014 hasAuthorship W2032582014A5089447078 @default.
- W2032582014 hasConcept C104317684 @default.
- W2032582014 hasConcept C121608353 @default.
- W2032582014 hasConcept C153911025 @default.
- W2032582014 hasConcept C190283241 @default.
- W2032582014 hasConcept C22615655 @default.
- W2032582014 hasConcept C502942594 @default.
- W2032582014 hasConcept C54009773 @default.
- W2032582014 hasConcept C54355233 @default.
- W2032582014 hasConcept C55493867 @default.
- W2032582014 hasConcept C555283112 @default.
- W2032582014 hasConcept C81885089 @default.
- W2032582014 hasConcept C86803240 @default.
- W2032582014 hasConcept C88045685 @default.
- W2032582014 hasConcept C96232424 @default.
- W2032582014 hasConceptScore W2032582014C104317684 @default.
- W2032582014 hasConceptScore W2032582014C121608353 @default.
- W2032582014 hasConceptScore W2032582014C153911025 @default.
- W2032582014 hasConceptScore W2032582014C190283241 @default.
- W2032582014 hasConceptScore W2032582014C22615655 @default.
- W2032582014 hasConceptScore W2032582014C502942594 @default.
- W2032582014 hasConceptScore W2032582014C54009773 @default.
- W2032582014 hasConceptScore W2032582014C54355233 @default.
- W2032582014 hasConceptScore W2032582014C55493867 @default.
- W2032582014 hasConceptScore W2032582014C555283112 @default.
- W2032582014 hasConceptScore W2032582014C81885089 @default.
- W2032582014 hasConceptScore W2032582014C86803240 @default.
- W2032582014 hasConceptScore W2032582014C88045685 @default.
- W2032582014 hasConceptScore W2032582014C96232424 @default.
- W2032582014 hasIssue "19" @default.
- W2032582014 hasLocation W20325820141 @default.
- W2032582014 hasLocation W20325820142 @default.
- W2032582014 hasOpenAccess W2032582014 @default.
- W2032582014 hasPrimaryLocation W20325820141 @default.
- W2032582014 hasRelatedWork W2065690661 @default.
- W2032582014 hasRelatedWork W2350597139 @default.
- W2032582014 hasRelatedWork W2351114716 @default.
- W2032582014 hasRelatedWork W2355164026 @default.
- W2032582014 hasRelatedWork W2355678225 @default.
- W2032582014 hasRelatedWork W2392186490 @default.
- W2032582014 hasRelatedWork W2418022953 @default.
- W2032582014 hasRelatedWork W2555524919 @default.
- W2032582014 hasRelatedWork W3028892192 @default.
- W2032582014 hasRelatedWork W3215939181 @default.
- W2032582014 hasVolume "65" @default.
- W2032582014 isParatext "false" @default.
- W2032582014 isRetracted "false" @default.
- W2032582014 magId "2032582014" @default.
- W2032582014 workType "article" @default.