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- W2032586245 abstract "A series of diol di-(tropane-3α-carboxylate) esters and diol di-(tropane-3β-carboxylate) esters were synthesized from 3-tropene-3-carboxylic acid and tropane-3β-carboxylic acid, respectively. The bivalent tropane-3-carboxylates were evaluated for their ability to inhibit [3H]cytisine binding at rat brain nicotinic acetylcholine receptors (nAChRs). In general the (3β,3β')-isomers were more potent than (3α,3α')-isomer and the (3β,3β')-decyl derivative (n = 10, Ki = 145 nM) exhibited the most potent affinity for nAChRs of the series." @default.
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- W2032586245 date "2007-11-01" @default.
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- W2032586245 title "Synthesis and nicotinic acetylcholine receptor affinity of bivalent tropane-3-carboxylates" @default.
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- W2032586245 doi "https://doi.org/10.1002/jhet.5570440629" @default.
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