FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032608933> ?p ?o ?g. }

• W2032608933 endingPage "659" @default.
• W2032608933 startingPage "659" @default.
• W2032608933 abstract "We appreciate the thoughtful comments from Dr. Soslow (1) and agree with many of his points. As he pointed out, many institutions reserve genetic testing for ovarian cancers with high-grade serous histology (2). We believe such a restriction in current practice is a mistake and will miss identifying carriers of mutations in BRCA1 and BRCA2 as well as other more recently identified ovarian cancer susceptibility genes, a point we were attempting to highlight by dividing our cases into serous and nonserous carcinomas. We agree that carcinosarcomas and some high-grade endometrioid carcinomas are likely to be closely related to high-grade serous carcinoma. The Cancer Genome Atlas (TCGA) only characterized pure high-grade serous ovarian carcinomas, however. Therefore, we do not have equally detailed molecular annotation on other histologic types, and it may be premature to lump all of these carcinomas into one bin.In a careful pathologic review, Gilks and colleagues (3) reclassified one third of endometrioid ovarian cancers as either serous or clear-cell carcinoma but two thirds were not reclassified, and those remaining endometrioid carcinomas did exhibit real differences from serous carcinomas, including a lack of WT-1 expression and a difference in outcome. Therefore, it seems unlikely that all high-grade endometrioid ovarian carcinomas are variants of serous carcinomas, though they may indeed demonstrate similarly high rates of mutation in homologous recombination (HR) genes. For example, we have previously identified a germline BRCA1 mutation in a patient with a stage IA, grade 3 endometrioid ovarian carcinoma with squamous differentiation, a feature considered characteristic of endometrioid (not serous) carcinoma.Until we move to a molecularly driven classification scheme, we must continue to understand mutation patterns in patients with ovarian cancer using current pathology schemes. In referring patients for genetic testing, both the Society of Gynecologic Oncology and the National Comprehensive Cancer Network recommend offering testing to all women with invasive ovarian carcinoma. Before we make those guidelines more restrictive, we should remember that clinicians rely on real-world pathology that represents greater variability than the carefully reviewed cases presented in our series and other research studies. Furthermore, even the largest population series of BRCA1 and BRCA2 testing have included only small numbers of nonserous cases (4), and data about the histologic predilection of inherited mutations in other ovarian cancer genes are even more limited (5). Therefore, until we understand mutational patterns in a much larger number of ovarian cancers than presented here, it would be unwise to alter genetic testing guidelines.Our data influenced several recently opened and upcoming PARP inhibitor trials to include endometrioid as well as serous ovarian carcinomas. Like Dr. Soslow, we argued during trial design that undifferentiated carcinomas and carcinosarcomas were likely serous variants and should also be included, but to no avail. Clearly, more data are needed to come to a consensus on the role of HR deficiency in various subtypes of ovarian carcinoma.See the original Letter to the Editor, p. 658No potential conflicts of interest were disclosed." @default.
• W2032608933 created "2016-06-24" @default.
• W2032608933 creator A5000478699 @default.
• W2032608933 creator A5043710182 @default.
• W2032608933 creator A5084420374 @default.
• W2032608933 creator A5090840695 @default.
• W2032608933 creator A5090852072 @default.
• W2032608933 date "2015-02-01" @default.
• W2032608933 modified "2023-10-18" @default.
• W2032608933 title "DNA Repair Mutations and Outcomes in Ovarian Cancer—Response" @default.
• W2032608933 cites W1992481478 @default.
• W2032608933 cites W2002419036 @default.
• W2032608933 cites W2011065238 @default.
• W2032608933 cites W2116186978 @default.
• W2032608933 cites W2169983032 @default.
• W2032608933 doi "https://doi.org/10.1158/1078-0432.ccr-14-2805" @default.
• W2032608933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25646182" @default.
• W2032608933 hasPublicationYear "2015" @default.
• W2032608933 type Work @default.
• W2032608933 sameAs 2032608933 @default.
• W2032608933 citedByCount "1" @default.
• W2032608933 countsByYear W20326089332022 @default.
• W2032608933 crossrefType "journal-article" @default.
• W2032608933 hasAuthorship W2032608933A5000478699 @default.
• W2032608933 hasAuthorship W2032608933A5043710182 @default.
• W2032608933 hasAuthorship W2032608933A5084420374 @default.
• W2032608933 hasAuthorship W2032608933A5090840695 @default.
• W2032608933 hasAuthorship W2032608933A5090852072 @default.
• W2032608933 hasBestOaLocation W20326089331 @default.
• W2032608933 hasConcept C104317684 @default.
• W2032608933 hasConcept C121608353 @default.
• W2032608933 hasConcept C126322002 @default.
• W2032608933 hasConcept C13514818 @default.
• W2032608933 hasConcept C142724271 @default.
• W2032608933 hasConcept C143998085 @default.
• W2032608933 hasConcept C150173356 @default.
• W2032608933 hasConcept C2777546739 @default.
• W2032608933 hasConcept C2777632260 @default.
• W2032608933 hasConcept C2778560582 @default.
• W2032608933 hasConcept C2780194787 @default.
• W2032608933 hasConcept C2780427987 @default.
• W2032608933 hasConcept C2780964533 @default.
• W2032608933 hasConcept C2781199814 @default.
• W2032608933 hasConcept C2908988626 @default.
• W2032608933 hasConcept C3019054536 @default.
• W2032608933 hasConcept C501734568 @default.
• W2032608933 hasConcept C502942594 @default.
• W2032608933 hasConcept C54355233 @default.
• W2032608933 hasConcept C71924100 @default.
• W2032608933 hasConcept C86803240 @default.
• W2032608933 hasConceptScore W2032608933C104317684 @default.
• W2032608933 hasConceptScore W2032608933C121608353 @default.
• W2032608933 hasConceptScore W2032608933C126322002 @default.
• W2032608933 hasConceptScore W2032608933C13514818 @default.
• W2032608933 hasConceptScore W2032608933C142724271 @default.
• W2032608933 hasConceptScore W2032608933C143998085 @default.
• W2032608933 hasConceptScore W2032608933C150173356 @default.
• W2032608933 hasConceptScore W2032608933C2777546739 @default.
• W2032608933 hasConceptScore W2032608933C2777632260 @default.
• W2032608933 hasConceptScore W2032608933C2778560582 @default.
• W2032608933 hasConceptScore W2032608933C2780194787 @default.
• W2032608933 hasConceptScore W2032608933C2780427987 @default.
• W2032608933 hasConceptScore W2032608933C2780964533 @default.
• W2032608933 hasConceptScore W2032608933C2781199814 @default.
• W2032608933 hasConceptScore W2032608933C2908988626 @default.
• W2032608933 hasConceptScore W2032608933C3019054536 @default.
• W2032608933 hasConceptScore W2032608933C501734568 @default.
• W2032608933 hasConceptScore W2032608933C502942594 @default.
• W2032608933 hasConceptScore W2032608933C54355233 @default.
• W2032608933 hasConceptScore W2032608933C71924100 @default.
• W2032608933 hasConceptScore W2032608933C86803240 @default.
• W2032608933 hasIssue "3" @default.
• W2032608933 hasLocation W20326089331 @default.
• W2032608933 hasLocation W20326089332 @default.
• W2032608933 hasOpenAccess W2032608933 @default.
• W2032608933 hasPrimaryLocation W20326089331 @default.
• W2032608933 hasRelatedWork W1577593758 @default.
• W2032608933 hasRelatedWork W2064330422 @default.
• W2032608933 hasRelatedWork W2068372669 @default.
• W2032608933 hasRelatedWork W2082690716 @default.
• W2032608933 hasRelatedWork W2187636381 @default.
• W2032608933 hasRelatedWork W2805900528 @default.
• W2032608933 hasRelatedWork W2921197000 @default.
• W2032608933 hasRelatedWork W3210326642 @default.
• W2032608933 hasRelatedWork W4243197346 @default.
• W2032608933 hasRelatedWork W4385380379 @default.
• W2032608933 hasVolume "21" @default.
• W2032608933 isParatext "false" @default.
• W2032608933 isRetracted "false" @default.
• W2032608933 magId "2032608933" @default.
• W2032608933 workType "article" @default.