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- W2032644318 abstract "In recent years, mass spectrometry has gained widespread use as an assay and screening technology in drug discovery because it enables sensitive, label-free detection of low-molecular weight modulators of biomolecules as well as sensitive and accurate detection of high-molecular weight modifications of biomolecules. Electrospray and matrix-assisted laser desorption ionization are the most widely used ionization techniques to identify chemical compounds interfering with enzymatic function, receptor–ligand binding or molecules modulating a protein–protein interaction of interest. Mass spectrometry based techniques are no longer restricted to screening in biochemical assay systems but have now become also applicable to imaging of biomolecules and chemical compounds in cell-based assay systems and even in highly complex tissue sections." @default.
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- W2032644318 date "2007-10-01" @default.
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- W2032644318 title "Application of mass spectrometry technologies for the discovery of low-molecular weight modulators of enzymes and protein–protein interactions" @default.
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