Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032646354> ?p ?o ?g. }
- W2032646354 endingPage "1306" @default.
- W2032646354 startingPage "1300" @default.
- W2032646354 abstract "The hypothesis that metabolic rate is inversely correlated with life span has long been debated. Another area of controversy has been the relationship between metabolic rate and aging. In most molecular studies key aspects of cellular metabolism have been shown to decline with age. Less attention has been focused on metabolic rate as an organism ages. We studied the survival of three Drosophila simulans fly lines and measured whole organism metabolic rate, mitochondrial DNA copy number and walking speed. Metabolic rate as assayed by CO(2) production did not correlate with median lifespan but increased by 0.43-1.14%/d. In contrast, mitochondrial DNA copy number decreased by 0.56-1.06%/d. Physical activity, as assayed by mean walking speed, did not change with age but was positively correlated with mitochondrial DNA copy number. One explanation for these data is that metabolic rate was increased, in the face of a reduced mitochondrial DNA copy number and capacity for oxidative metabolism, to maintain a constant bioenergetic demand (physical activity). Alternatively, metabolic rate may increase to provide energy for the repair of cellular damage or due to a shift in metabolic substrate use over time." @default.
- W2032646354 created "2016-06-24" @default.
- W2032646354 creator A5008384445 @default.
- W2032646354 creator A5071536343 @default.
- W2032646354 creator A5084400853 @default.
- W2032646354 date "2007-12-01" @default.
- W2032646354 modified "2023-09-27" @default.
- W2032646354 title "Working harder to stay alive: Metabolic rate increases with age in Drosophila simulans but does not correlate with life span" @default.
- W2032646354 cites W1565127991 @default.
- W2032646354 cites W1591252439 @default.
- W2032646354 cites W1597488164 @default.
- W2032646354 cites W1832024365 @default.
- W2032646354 cites W1845170918 @default.
- W2032646354 cites W1963878813 @default.
- W2032646354 cites W1967722388 @default.
- W2032646354 cites W1970452249 @default.
- W2032646354 cites W1979048203 @default.
- W2032646354 cites W1982563082 @default.
- W2032646354 cites W1991132149 @default.
- W2032646354 cites W1995869264 @default.
- W2032646354 cites W1999312292 @default.
- W2032646354 cites W2000907138 @default.
- W2032646354 cites W2001791959 @default.
- W2032646354 cites W2002973721 @default.
- W2032646354 cites W2006132005 @default.
- W2032646354 cites W2014569635 @default.
- W2032646354 cites W2026153930 @default.
- W2032646354 cites W2030389371 @default.
- W2032646354 cites W2042928173 @default.
- W2032646354 cites W2047529383 @default.
- W2032646354 cites W2050120083 @default.
- W2032646354 cites W2057539850 @default.
- W2032646354 cites W2064692664 @default.
- W2032646354 cites W2065646103 @default.
- W2032646354 cites W2069154171 @default.
- W2032646354 cites W2071012903 @default.
- W2032646354 cites W2071212071 @default.
- W2032646354 cites W2072199451 @default.
- W2032646354 cites W2073349608 @default.
- W2032646354 cites W2074473663 @default.
- W2032646354 cites W2080272457 @default.
- W2032646354 cites W2088148809 @default.
- W2032646354 cites W2105537673 @default.
- W2032646354 cites W2105765501 @default.
- W2032646354 cites W2113007696 @default.
- W2032646354 cites W2113279188 @default.
- W2032646354 cites W2114936974 @default.
- W2032646354 cites W2115074336 @default.
- W2032646354 cites W2117219289 @default.
- W2032646354 cites W2131207288 @default.
- W2032646354 cites W2151401570 @default.
- W2032646354 cites W2162270543 @default.
- W2032646354 cites W2171958953 @default.
- W2032646354 cites W2176491655 @default.
- W2032646354 cites W2315512556 @default.
- W2032646354 doi "https://doi.org/10.1016/j.jinsphys.2007.07.006" @default.
- W2032646354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17915248" @default.
- W2032646354 hasPublicationYear "2007" @default.
- W2032646354 type Work @default.
- W2032646354 sameAs 2032646354 @default.
- W2032646354 citedByCount "29" @default.
- W2032646354 countsByYear W20326463542012 @default.
- W2032646354 countsByYear W20326463542013 @default.
- W2032646354 countsByYear W20326463542014 @default.
- W2032646354 countsByYear W20326463542015 @default.
- W2032646354 countsByYear W20326463542016 @default.
- W2032646354 countsByYear W20326463542017 @default.
- W2032646354 countsByYear W20326463542018 @default.
- W2032646354 countsByYear W20326463542019 @default.
- W2032646354 countsByYear W20326463542020 @default.
- W2032646354 crossrefType "journal-article" @default.
- W2032646354 hasAuthorship W2032646354A5008384445 @default.
- W2032646354 hasAuthorship W2032646354A5071536343 @default.
- W2032646354 hasAuthorship W2032646354A5084400853 @default.
- W2032646354 hasConcept C100206155 @default.
- W2032646354 hasConcept C104317684 @default.
- W2032646354 hasConcept C134018914 @default.
- W2032646354 hasConcept C24586158 @default.
- W2032646354 hasConcept C2776041557 @default.
- W2032646354 hasConcept C2776759703 @default.
- W2032646354 hasConcept C2780104201 @default.
- W2032646354 hasConcept C28859421 @default.
- W2032646354 hasConcept C2988516024 @default.
- W2032646354 hasConcept C2991809073 @default.
- W2032646354 hasConcept C2992768293 @default.
- W2032646354 hasConcept C54355233 @default.
- W2032646354 hasConcept C55493867 @default.
- W2032646354 hasConcept C57600042 @default.
- W2032646354 hasConcept C62231903 @default.
- W2032646354 hasConcept C71924100 @default.
- W2032646354 hasConcept C78458016 @default.
- W2032646354 hasConcept C86803240 @default.
- W2032646354 hasConcept C99508421 @default.
- W2032646354 hasConceptScore W2032646354C100206155 @default.
- W2032646354 hasConceptScore W2032646354C104317684 @default.
- W2032646354 hasConceptScore W2032646354C134018914 @default.
- W2032646354 hasConceptScore W2032646354C24586158 @default.
- W2032646354 hasConceptScore W2032646354C2776041557 @default.