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• W2032656590 abstract "We used a modification of the alkaline single-cell gel electrophoresis (SCG) (Comet) assay to evaluate the in vivo genotoxicity of two potent rodent bladder carcinogens, o-anisidine and p-cresidine, in mouse liver, lung, kidney, brain, and bone marrow, and in the mucosa of stomach, colon, and bladder. Male CD-1 mice (8 weeks old) were sacrificed 3 and 24 h after oral administration of o-anisidine at 690 mg/kg or p-cresidine at 595 mg/kg. Both chemicals were dissolved in olive oil. Both chemicals yielded statistically significant DNA damage in bladder mucosa 3 and 24 h after treatment. o-Anisidine yielded DNA damage in the colon at 3 h, but not at 24 h. No significant effects were observed in any other organs. Our results suggest the importance of the urinary bladder as a sentinel organ for evaluating chemical genotoxicity in rodents." @default.
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• W2032656590 date "1998-01-01" @default.
• W2032656590 modified "2023-10-01" @default.
• W2032656590 title "Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine" @default.
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• W2032656590 doi "https://doi.org/10.1016/s1383-5718(97)00183-6" @default.
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