FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032657795> ?p ?o ?g. }

• W2032657795 endingPage "534" @default.
• W2032657795 startingPage "523" @default.
• W2032657795 abstract "The kinase signaling cascades related to mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2, respectively) are attractive targets for pharmaceutical intervention, especially for neural injury. Therefore, we have developed a high throughput and cost-effective detection platform for measuring selective activity of MSK1/MSK2 in cells. Through the serial monitoring of both the p38 mitogen-activated protein kinase (stress-activated protein kinase 2B)–MSK1/MSK2– cyclic AMP response element binding protein (CREB)/activating transcription factor 1 (ATF1) pathway and the p38–mammalian heat shock protein 27 (Hsp27) pathway in HeLa cells treated with anisomycin, two selective MSK1 inhibitors showed inhibition of CREB (Ser-133) and ATF1 (Ser-63) phosphorylation and no interference with Hsp-27 phosphorylation (Ser-82). On the other hand, the p38 inhibitor SB-220025 showed equipotent inhibition of CREB/ATF1 and Hsp27 phosphorylation. This study demonstrated that the specific inhibition of a target kinase could be subsequently monitored by a secondary assay that measures the intervention arising from the modulation of off-target kinases. Our established system is applicable to inhibitor screening and drug discovery related to MSK1/MSK2." @default.
• W2032657795 created "2016-06-24" @default.
• W2032657795 creator A5002655479 @default.
• W2032657795 creator A5014826233 @default.
• W2032657795 creator A5029873173 @default.
• W2032657795 creator A5039078579 @default.
• W2032657795 creator A5048966876 @default.
• W2032657795 creator A5080575846 @default.
• W2032657795 date "2007-08-01" @default.
• W2032657795 modified "2023-09-26" @default.
• W2032657795 title "Dual Enzyme-Linked Immunosorbent Assay System for Detection of Endogenous Kinase Activities of Mitogen- and Stress-Activated Protein Kinase-1/2" @default.
• W2032657795 cites W1487371392 @default.
• W2032657795 cites W1528562972 @default.
• W2032657795 cites W1933732812 @default.
• W2032657795 cites W1964887620 @default.
• W2032657795 cites W1977707794 @default.
• W2032657795 cites W1991001144 @default.
• W2032657795 cites W1991783074 @default.
• W2032657795 cites W1995527584 @default.
• W2032657795 cites W2003506860 @default.
• W2032657795 cites W2018928754 @default.
• W2032657795 cites W2019571270 @default.
• W2032657795 cites W2022885258 @default.
• W2032657795 cites W2032796670 @default.
• W2032657795 cites W2035936653 @default.
• W2032657795 cites W2042976701 @default.
• W2032657795 cites W2044175451 @default.
• W2032657795 cites W2045401053 @default.
• W2032657795 cites W2048172377 @default.
• W2032657795 cites W2052750950 @default.
• W2032657795 cites W2062973172 @default.
• W2032657795 cites W2066469176 @default.
• W2032657795 cites W2067388503 @default.
• W2032657795 cites W2083624932 @default.
• W2032657795 cites W2086655427 @default.
• W2032657795 cites W2088995677 @default.
• W2032657795 cites W2094382100 @default.
• W2032657795 cites W2097066538 @default.
• W2032657795 cites W2100712519 @default.
• W2032657795 cites W2131162745 @default.
• W2032657795 cites W2137385309 @default.
• W2032657795 cites W2159871322 @default.
• W2032657795 doi "https://doi.org/10.1089/adt.2007.063" @default.
• W2032657795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17767420" @default.
• W2032657795 hasPublicationYear "2007" @default.
• W2032657795 type Work @default.
• W2032657795 sameAs 2032657795 @default.
• W2032657795 citedByCount "0" @default.
• W2032657795 crossrefType "journal-article" @default.
• W2032657795 hasAuthorship W2032657795A5002655479 @default.
• W2032657795 hasAuthorship W2032657795A5014826233 @default.
• W2032657795 hasAuthorship W2032657795A5029873173 @default.
• W2032657795 hasAuthorship W2032657795A5039078579 @default.
• W2032657795 hasAuthorship W2032657795A5048966876 @default.
• W2032657795 hasAuthorship W2032657795A5080575846 @default.
• W2032657795 hasConcept C104317684 @default.
• W2032657795 hasConcept C11960822 @default.
• W2032657795 hasConcept C124160383 @default.
• W2032657795 hasConcept C132149769 @default.
• W2032657795 hasConcept C137361374 @default.
• W2032657795 hasConcept C153911025 @default.
• W2032657795 hasConcept C159479382 @default.
• W2032657795 hasConcept C161238802 @default.
• W2032657795 hasConcept C1629964 @default.
• W2032657795 hasConcept C163035849 @default.
• W2032657795 hasConcept C184235292 @default.
• W2032657795 hasConcept C185592680 @default.
• W2032657795 hasConcept C2778073123 @default.
• W2032657795 hasConcept C51551487 @default.
• W2032657795 hasConcept C55493867 @default.
• W2032657795 hasConcept C59143045 @default.
• W2032657795 hasConcept C82495950 @default.
• W2032657795 hasConcept C86339819 @default.
• W2032657795 hasConcept C86803240 @default.
• W2032657795 hasConcept C90934575 @default.
• W2032657795 hasConcept C95444343 @default.
• W2032657795 hasConcept C97029542 @default.
• W2032657795 hasConceptScore W2032657795C104317684 @default.
• W2032657795 hasConceptScore W2032657795C11960822 @default.
• W2032657795 hasConceptScore W2032657795C124160383 @default.
• W2032657795 hasConceptScore W2032657795C132149769 @default.
• W2032657795 hasConceptScore W2032657795C137361374 @default.
• W2032657795 hasConceptScore W2032657795C153911025 @default.
• W2032657795 hasConceptScore W2032657795C159479382 @default.
• W2032657795 hasConceptScore W2032657795C161238802 @default.
• W2032657795 hasConceptScore W2032657795C1629964 @default.
• W2032657795 hasConceptScore W2032657795C163035849 @default.
• W2032657795 hasConceptScore W2032657795C184235292 @default.
• W2032657795 hasConceptScore W2032657795C185592680 @default.
• W2032657795 hasConceptScore W2032657795C2778073123 @default.
• W2032657795 hasConceptScore W2032657795C51551487 @default.
• W2032657795 hasConceptScore W2032657795C55493867 @default.
• W2032657795 hasConceptScore W2032657795C59143045 @default.
• W2032657795 hasConceptScore W2032657795C82495950 @default.
• W2032657795 hasConceptScore W2032657795C86339819 @default.
• W2032657795 hasConceptScore W2032657795C86803240 @default.
• W2032657795 hasConceptScore W2032657795C90934575 @default.
• W2032657795 hasConceptScore W2032657795C95444343 @default.

• next