FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032664721> ?p ?o ?g. }

• W2032664721 endingPage "236" @default.
• W2032664721 startingPage "223" @default.
• W2032664721 abstract "The absorption, disposition, and metabolism of [14C]thiophene was investigated in rats following nose‐only inhalation exposure at 8000 ppm for 1 h. Under these exposure conditions, it was estimated that approximately 16.3% (493 μmol) of the inhaled thiophene was absorbed from the respiratory system. Within 72 h following exposure, a total of 488 μmol of thiophene equivalents (99% of that retained) was excreted, of which 360.4 μmol (73.9% of the total excreted radioactivity) was in expired air, 120.7 μmol (24.8%) was in urine, 3 μmol (0.6%) was in feces, and 3.7 μmol (0.8%) was in the cage wash. Excretion took place primarily within the first 8 h, during which 91% of the total radioactivity excreted was collected. The thiophene equivalents remaining in tissues at 72 h were estimated to total 5.1 μmol (1.0% of the retained radioactivity). Exhaled radioactivity was identified as thiophene. No 14CO2 was detected in the expired air. After 1 h following exposure, the elimination of thiophene equivalents from plasma was monophasic, with a half‐time of 3.6 h. The elimination of thiophene equivalents from blood cells was biphasic, with half‐times of 2.9 h and 9.1 d. The blood cells/plasma concentration ratios of thiophene equivalents ranged from 3 to 13, with the higher ratio observed at the 12‐h time interval. At 72 h after exposure, blood cells contained the highest concentration of thiophene equivalents, approximately fourfold higher than that of the liver, which contained the second highest concentration. Kidney, heart, and lung contained similar but lower concentrations than liver, while brain, fat, and skeletal muscles contained the lowest concentrations. In summary, this study demonstrates that thiophene was absorbed from the respiratory system, and the majority of the absorbed thiophene was eliminated unchanged in the exhaled air, while a smaller fraction was metabolized and eliminated in urine." @default.
• W2032664721 created "2016-06-24" @default.
• W2032664721 creator A5050737001 @default.
• W2032664721 creator A5062873684 @default.
• W2032664721 creator A5090426719 @default.
• W2032664721 date "1993-06-01" @default.
• W2032664721 modified "2023-09-24" @default.
• W2032664721 title "Pulmonary absorption and disposition of [14C]thiophene in rats following nose‐only inhalation exposure" @default.
• W2032664721 cites W1543823041 @default.
• W2032664721 cites W1608691218 @default.
• W2032664721 cites W1964495485 @default.
• W2032664721 cites W1971679392 @default.
• W2032664721 cites W1975950370 @default.
• W2032664721 cites W1984669684 @default.
• W2032664721 cites W2010219284 @default.
• W2032664721 cites W2016067140 @default.
• W2032664721 cites W2028054748 @default.
• W2032664721 cites W2029788773 @default.
• W2032664721 cites W2033068727 @default.
• W2032664721 cites W2036540361 @default.
• W2032664721 cites W2039191881 @default.
• W2032664721 cites W2090789479 @default.
• W2032664721 cites W2091329370 @default.
• W2032664721 cites W2131055506 @default.
• W2032664721 doi "https://doi.org/10.1080/15287399309531747" @default.
• W2032664721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8501766" @default.
• W2032664721 hasPublicationYear "1993" @default.
• W2032664721 type Work @default.
• W2032664721 sameAs 2032664721 @default.
• W2032664721 citedByCount "0" @default.
• W2032664721 crossrefType "journal-article" @default.
• W2032664721 hasAuthorship W2032664721A5050737001 @default.
• W2032664721 hasAuthorship W2032664721A5062873684 @default.
• W2032664721 hasAuthorship W2032664721A5090426719 @default.
• W2032664721 hasConcept C10146269 @default.
• W2032664721 hasConcept C121332964 @default.
• W2032664721 hasConcept C125287762 @default.
• W2032664721 hasConcept C126322002 @default.
• W2032664721 hasConcept C151730666 @default.
• W2032664721 hasConcept C177322064 @default.
• W2032664721 hasConcept C178790620 @default.
• W2032664721 hasConcept C185592680 @default.
• W2032664721 hasConcept C195289149 @default.
• W2032664721 hasConcept C24890656 @default.
• W2032664721 hasConcept C2776954882 @default.
• W2032664721 hasConcept C2779777708 @default.
• W2032664721 hasConcept C2779953032 @default.
• W2032664721 hasConcept C2780026642 @default.
• W2032664721 hasConcept C29730261 @default.
• W2032664721 hasConcept C42219234 @default.
• W2032664721 hasConcept C43617362 @default.
• W2032664721 hasConcept C534529494 @default.
• W2032664721 hasConcept C55493867 @default.
• W2032664721 hasConcept C61716771 @default.
• W2032664721 hasConcept C62231903 @default.
• W2032664721 hasConcept C71924100 @default.
• W2032664721 hasConcept C86803240 @default.
• W2032664721 hasConceptScore W2032664721C10146269 @default.
• W2032664721 hasConceptScore W2032664721C121332964 @default.
• W2032664721 hasConceptScore W2032664721C125287762 @default.
• W2032664721 hasConceptScore W2032664721C126322002 @default.
• W2032664721 hasConceptScore W2032664721C151730666 @default.
• W2032664721 hasConceptScore W2032664721C177322064 @default.
• W2032664721 hasConceptScore W2032664721C178790620 @default.
• W2032664721 hasConceptScore W2032664721C185592680 @default.
• W2032664721 hasConceptScore W2032664721C195289149 @default.
• W2032664721 hasConceptScore W2032664721C24890656 @default.
• W2032664721 hasConceptScore W2032664721C2776954882 @default.
• W2032664721 hasConceptScore W2032664721C2779777708 @default.
• W2032664721 hasConceptScore W2032664721C2779953032 @default.
• W2032664721 hasConceptScore W2032664721C2780026642 @default.
• W2032664721 hasConceptScore W2032664721C29730261 @default.
• W2032664721 hasConceptScore W2032664721C42219234 @default.
• W2032664721 hasConceptScore W2032664721C43617362 @default.
• W2032664721 hasConceptScore W2032664721C534529494 @default.
• W2032664721 hasConceptScore W2032664721C55493867 @default.
• W2032664721 hasConceptScore W2032664721C61716771 @default.
• W2032664721 hasConceptScore W2032664721C62231903 @default.
• W2032664721 hasConceptScore W2032664721C71924100 @default.
• W2032664721 hasConceptScore W2032664721C86803240 @default.
• W2032664721 hasIssue "2" @default.
• W2032664721 hasLocation W20326647211 @default.
• W2032664721 hasLocation W20326647212 @default.
• W2032664721 hasOpenAccess W2032664721 @default.
• W2032664721 hasPrimaryLocation W20326647211 @default.
• W2032664721 hasRelatedWork W1925982542 @default.
• W2032664721 hasRelatedWork W1964074988 @default.
• W2032664721 hasRelatedWork W2039907201 @default.
• W2032664721 hasRelatedWork W2042767146 @default.
• W2032664721 hasRelatedWork W2047666596 @default.
• W2032664721 hasRelatedWork W2050438044 @default.
• W2032664721 hasRelatedWork W2409885688 @default.
• W2032664721 hasRelatedWork W2903773567 @default.
• W2032664721 hasRelatedWork W40521540 @default.
• W2032664721 hasRelatedWork W4301113754 @default.
• W2032664721 hasVolume "39" @default.
• W2032664721 isParatext "false" @default.
• W2032664721 isRetracted "false" @default.

• next