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• W2032667722 abstract "Leptin controls body weight by activating the long form of the leptin receptor (LEPRb). Janus kinase 2 (JAK2) is associated with LEPRb and autophosphorylates in response to leptin. JAK2 also phosphorylates LEPRb, STAT3, and multiple other downstream molecules. Surprisingly, here we show that JAK2 is not required for leptin stimulation of STAT3 phosphorylation. Leptin time- and dose-dependently stimulated tyrosine phosphorylation of STAT3 in both human and mouse JAK2-null cells. Leptin also increased the viability of JAK2-null cells. Overexpression of c-Src or Fyn, two Src family members, promoted STAT3 phosphorylation, whereas inhibition of the endogenous Src family members by either pharmacological inhibitors or dominant negative Src(K298M) decreased the ability of leptin to stimulate the phosphorylation of STAT3 and ERK1/2. Leptin also stimulated tyrosine phosphorylation of kinase-inactive JAK2(K882E) in JAK2-null cells. Overexpression of JAK2(K882E) enhanced the ability of leptin to stimulate STAT3 phosphorylation in JAK2-null cells. Tyr1138 in LEPRb was required for leptin-stimulated phosphorylation of STAT3 but not JAK2(K882E). These data suggest that leptin stimulates non-JAK2 tyrosine kinase(s), including the Src family members, which phosphorylate JAK2, STAT3, and other molecules downstream of LEPRb. JAK2 mediates leptin signaling by both phosphorylating its substrates and forming a signaling complex as a scaffolding/adaptor protein. The non-JAK2 kinase(s) and JAK2 may act coordinately and synergistically to mediate leptin response." @default.
• W2032667722 created "2016-06-24" @default.
• W2032667722 creator A5021140361 @default.
• W2032667722 creator A5027212562 @default.
• W2032667722 creator A5028313889 @default.
• W2032667722 date "2008-10-01" @default.
• W2032667722 modified "2023-10-16" @default.
• W2032667722 title "Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways" @default.
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• W2032667722 doi "https://doi.org/10.1074/jbc.m805545200" @default.
• W2032667722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568905" @default.
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• W2032667722 hasPublicationYear "2008" @default.
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