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- W2032677790 abstract "1. The effect of the permeant anion, tetraphenylboron, on the uptake of metabolite anions has been examined in rat liver mitochondria. 2. Tetraphenylboron, inhibits the translocation of ADP and ATP, and the uptake of succinate, malonate, and inorganic phosphate. The uptake of malonate is inhibited by picric acie, whereas salicylate and nitrate have no effect on metabolite anion uptake at concentrations examined. 3. Tetraphenylarsonium has little or no stimulatory effect on the uptake of metabolite anions at concentrations up to 10 mM. 4. Mg2+ selectively relieves the inhibition of the ATP exchange by tetraphenylboron, but has no similar effect on the uptake of ADP or succinate. 5. Tetraphenylboron decreases the respiratory control ratio by inhibiting ADP exchange, rather than by stimulating State IV respiration. There is only a slight ATPase activity associated with tetraphenylboron in the presence of Mg2+. 6. The primary effect of tetraphenylboron is therefore a generalized inhibition of the binding of all metabolic anions to the membrane." @default.
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- W2032677790 date "1973-09-01" @default.
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- W2032677790 title "Inhibition of metabolite anion uptake in mitochondria by tetraphenylboron" @default.
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- W2032677790 doi "https://doi.org/10.1016/0005-2736(73)90202-2" @default.
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