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• W2032704623 abstract "Purpose/Objective(s)Standard esophagogram criteria are unreliable for staging esophageal carcinoma therapy; however, change of tumor shape can identify patients who have achieved a clinical response. In the current study the authors prospectively compared survival between patients classified as responders and those classified as nonresponders by esophagogram.Materials/MethodsThe shape of the tumor in esophagogram was check before and after neoadjuvant therapy in patients who were candidates for multimodality treatment. Response was defined as no visible carcinoma in esophagogram with barium.ResultsOf 229 patients with thoracic esophageal squamous cell carcinoma, all patients underwent preoperative RT . The median age was 56 years, and most patients were male (76.4%). Operations performed included Ivor-Lewis (60.3%), transhiatal (3.1%), three-hole (35.8%), or left thoracoabdominal (0.9%) esophagectomy. Perioperative mortality rate was 4.8%. Median overall survival (OS) of the entire group was 24 months, and the 5-year and 10-year OS rate was 30% and 21%.Overall, patients with responders had a median survival and 5-year,10-year survival of 41.4 months, 49%, 33.1% compared with 19.2 months,26.6%, 18.9% for non-responders (p = 0.024). Patients with pathologic completely response (pCR) had an improved OS and disease-free survival (DFS) compared with those patients who were not pCR (p = 0.003 and p < 0.0005, respectively). Esophagogram with barium cannot predict patient's pathologic response who underwent preoperative radiotherapy.ConclusionsPatients with esophageal carcinoma who respond to neoadjuvant treatment as identified by Esophagogram with barium in tumor shape have a significantly better prognosis than nonresponders. Purpose/Objective(s)Standard esophagogram criteria are unreliable for staging esophageal carcinoma therapy; however, change of tumor shape can identify patients who have achieved a clinical response. In the current study the authors prospectively compared survival between patients classified as responders and those classified as nonresponders by esophagogram. Standard esophagogram criteria are unreliable for staging esophageal carcinoma therapy; however, change of tumor shape can identify patients who have achieved a clinical response. In the current study the authors prospectively compared survival between patients classified as responders and those classified as nonresponders by esophagogram. Materials/MethodsThe shape of the tumor in esophagogram was check before and after neoadjuvant therapy in patients who were candidates for multimodality treatment. Response was defined as no visible carcinoma in esophagogram with barium. The shape of the tumor in esophagogram was check before and after neoadjuvant therapy in patients who were candidates for multimodality treatment. Response was defined as no visible carcinoma in esophagogram with barium. ResultsOf 229 patients with thoracic esophageal squamous cell carcinoma, all patients underwent preoperative RT . The median age was 56 years, and most patients were male (76.4%). Operations performed included Ivor-Lewis (60.3%), transhiatal (3.1%), three-hole (35.8%), or left thoracoabdominal (0.9%) esophagectomy. Perioperative mortality rate was 4.8%. Median overall survival (OS) of the entire group was 24 months, and the 5-year and 10-year OS rate was 30% and 21%.Overall, patients with responders had a median survival and 5-year,10-year survival of 41.4 months, 49%, 33.1% compared with 19.2 months,26.6%, 18.9% for non-responders (p = 0.024). Patients with pathologic completely response (pCR) had an improved OS and disease-free survival (DFS) compared with those patients who were not pCR (p = 0.003 and p < 0.0005, respectively). Esophagogram with barium cannot predict patient's pathologic response who underwent preoperative radiotherapy. Of 229 patients with thoracic esophageal squamous cell carcinoma, all patients underwent preoperative RT . The median age was 56 years, and most patients were male (76.4%). Operations performed included Ivor-Lewis (60.3%), transhiatal (3.1%), three-hole (35.8%), or left thoracoabdominal (0.9%) esophagectomy. Perioperative mortality rate was 4.8%. Median overall survival (OS) of the entire group was 24 months, and the 5-year and 10-year OS rate was 30% and 21%.Overall, patients with responders had a median survival and 5-year,10-year survival of 41.4 months, 49%, 33.1% compared with 19.2 months,26.6%, 18.9% for non-responders (p = 0.024). Patients with pathologic completely response (pCR) had an improved OS and disease-free survival (DFS) compared with those patients who were not pCR (p = 0.003 and p < 0.0005, respectively). Esophagogram with barium cannot predict patient's pathologic response who underwent preoperative radiotherapy. ConclusionsPatients with esophageal carcinoma who respond to neoadjuvant treatment as identified by Esophagogram with barium in tumor shape have a significantly better prognosis than nonresponders. Patients with esophageal carcinoma who respond to neoadjuvant treatment as identified by Esophagogram with barium in tumor shape have a significantly better prognosis than nonresponders." @default.
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• W2032704623 date "2010-11-01" @default.
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• W2032704623 title "Esophagogram with Barium Assessment of Multimodality Therapy Predicts Survival of Esophageal Squamous Cell Carcinoma Patients" @default.
• W2032704623 doi "https://doi.org/10.1016/j.ijrobp.2010.07.1657" @default.
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