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• W2032711916 endingPage "102" @default.
• W2032711916 startingPage "96" @default.
• W2032711916 abstract "A peroxidase-mimic DNAzyme is a G-quadruplex (G4) DNA-hemin complex, in which the G4-DNA resembles an apoenzyme, and hemin is the cofactor for hydrogen peroxide (H2O2) catalysis. Twenty-one-mer CatG4 is a well-proven G4-DNA as well as a hemin-binding aptamer for constituting a DNAzyme. This work studied if a multivalent DNAzyme with accelerated catalysis could be constructed using a multimeric CatG4 with hemin. We compared CatG4 monomer, dimer, trimer, and tetramer, which were prepared by custom oligo synthesis, for G4 structure formation. According to circular dichroism (CD) analysis, we found that a CatG4 multimer exhibited more active G4 conformation than the sum effect of equal-number CatG4 monomers. However, the DNAzyme kinetics was not improved monotonically along with the subunit number of a multimeric CatG4. It was the trivalent DNAzyme, trimeric CatG4:hemin, resulting in the rapidest H2O2 catalysis instead of a tetravalent one. We discovered that the trivalent DNAzyme's highest catalytic rate was correlated to its most stable hemin-binding G4 structure, evidenced by CD melting temperature analysis. Finally, a trivalent DNAzyme-based colorimetric glucose assay with a detection limit as low as 10 μM was demonstrated, and this assay did not need adenosine 5'-tri-phosphate disodium salt hydrate (ATP) as a DNAzyme boosting agent." @default.
• W2032711916 created "2016-06-24" @default.
• W2032711916 creator A5010613776 @default.
• W2032711916 creator A5058795235 @default.
• W2032711916 creator A5073426711 @default.
• W2032711916 date "2015-01-01" @default.
• W2032711916 modified "2023-10-13" @default.
• W2032711916 title "Synthetic multivalent DNAzymes for enhanced hydrogen peroxide catalysis and sensitive colorimetric glucose detection" @default.
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• W2032711916 doi "https://doi.org/10.1016/j.aca.2014.11.031" @default.
• W2032711916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25542363" @default.
• W2032711916 hasPublicationYear "2015" @default.
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