Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032717282> ?p ?o ?g. }
- W2032717282 endingPage "225" @default.
- W2032717282 startingPage "216" @default.
- W2032717282 abstract "The assembly of multisubunit GABAA receptors in specific neuronal populations is a complex process which is poorly understood. To begin to examine receptor assembly, alpha 1, beta 2/3, and gamma 2 subunit polypeptide expression and association, as well as receptor binding, were examined in cultured rat cerebellar granule neurons. Western blots revealed two alpha 1-immunoreactive proteins. A 39 kDa species was maximal at 2 days in culture and subsequently declined. In contrast, a 51 kDa polypeptide, the anticipated size of the mature alpha 1 subunit, was first detected at 4 days and increased throughout the culture period. Additional studies demonstrated that the beta 2/3 and gamma 2 subunits were detectable at 2 days and attained maximal levels by 6 days. The level of [3H]Ro15-1788 binding, a measure of assembled receptors, rose in parallel with the increases in the 51 kDa alpha 1, beta 2/3 and gamma 2 subunits. Moreover, the 51 kDa alpha 1, beta 2/3, and gamma 2 subunits were associated in receptor complexes. However, immunohistochemical studies demonstrated the presence of substantial intracellular subunit staining. This finding suggest that only some of the subunits expressed in granule neurons contribute to functional GABAA receptors on the cell surface." @default.
- W2032717282 created "2016-06-24" @default.
- W2032717282 creator A5010941476 @default.
- W2032717282 creator A5055509540 @default.
- W2032717282 creator A5076450562 @default.
- W2032717282 creator A5077849622 @default.
- W2032717282 creator A5079422444 @default.
- W2032717282 date "1996-12-01" @default.
- W2032717282 modified "2023-10-17" @default.
- W2032717282 title "GABAA receptor subunit expression and assembly in cultured rat cerebellar granule neurons" @default.
- W2032717282 cites W1499161600 @default.
- W2032717282 cites W1499228887 @default.
- W2032717282 cites W1504992746 @default.
- W2032717282 cites W1505903665 @default.
- W2032717282 cites W1528717760 @default.
- W2032717282 cites W1538927534 @default.
- W2032717282 cites W1574239291 @default.
- W2032717282 cites W1595197310 @default.
- W2032717282 cites W1599442582 @default.
- W2032717282 cites W1606910143 @default.
- W2032717282 cites W1616776977 @default.
- W2032717282 cites W165635918 @default.
- W2032717282 cites W1657090468 @default.
- W2032717282 cites W1775749144 @default.
- W2032717282 cites W1784526106 @default.
- W2032717282 cites W1908131908 @default.
- W2032717282 cites W1952343891 @default.
- W2032717282 cites W1955394373 @default.
- W2032717282 cites W1970249359 @default.
- W2032717282 cites W1973238622 @default.
- W2032717282 cites W1982860158 @default.
- W2032717282 cites W1983966699 @default.
- W2032717282 cites W1983967908 @default.
- W2032717282 cites W1996928890 @default.
- W2032717282 cites W2001295380 @default.
- W2032717282 cites W2007751253 @default.
- W2032717282 cites W2008344134 @default.
- W2032717282 cites W2010507492 @default.
- W2032717282 cites W2023468172 @default.
- W2032717282 cites W2025810192 @default.
- W2032717282 cites W2039163989 @default.
- W2032717282 cites W2039507520 @default.
- W2032717282 cites W2039867424 @default.
- W2032717282 cites W2043045309 @default.
- W2032717282 cites W2051248831 @default.
- W2032717282 cites W2063440652 @default.
- W2032717282 cites W2066474203 @default.
- W2032717282 cites W2076300996 @default.
- W2032717282 cites W2077065023 @default.
- W2032717282 cites W2078319476 @default.
- W2032717282 cites W2085612074 @default.
- W2032717282 cites W2088115099 @default.
- W2032717282 cites W2106899177 @default.
- W2032717282 cites W2129151401 @default.
- W2032717282 cites W2131231986 @default.
- W2032717282 doi "https://doi.org/10.1016/s0165-3806(96)00143-5" @default.
- W2032717282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8997506" @default.
- W2032717282 hasPublicationYear "1996" @default.
- W2032717282 type Work @default.
- W2032717282 sameAs 2032717282 @default.
- W2032717282 citedByCount "8" @default.
- W2032717282 countsByYear W20327172822018 @default.
- W2032717282 crossrefType "journal-article" @default.
- W2032717282 hasAuthorship W2032717282A5010941476 @default.
- W2032717282 hasAuthorship W2032717282A5055509540 @default.
- W2032717282 hasAuthorship W2032717282A5076450562 @default.
- W2032717282 hasAuthorship W2032717282A5077849622 @default.
- W2032717282 hasAuthorship W2032717282A5079422444 @default.
- W2032717282 hasConcept C104292427 @default.
- W2032717282 hasConcept C104317684 @default.
- W2032717282 hasConcept C126322002 @default.
- W2032717282 hasConcept C134018914 @default.
- W2032717282 hasConcept C153911025 @default.
- W2032717282 hasConcept C159110408 @default.
- W2032717282 hasConcept C168258287 @default.
- W2032717282 hasConcept C170493617 @default.
- W2032717282 hasConcept C19876734 @default.
- W2032717282 hasConcept C2775944032 @default.
- W2032717282 hasConcept C2776464000 @default.
- W2032717282 hasConcept C2778888523 @default.
- W2032717282 hasConcept C2779570518 @default.
- W2032717282 hasConcept C2779652256 @default.
- W2032717282 hasConcept C2910882050 @default.
- W2032717282 hasConcept C49453240 @default.
- W2032717282 hasConcept C529278444 @default.
- W2032717282 hasConcept C55493867 @default.
- W2032717282 hasConcept C64943373 @default.
- W2032717282 hasConcept C71924100 @default.
- W2032717282 hasConcept C79879829 @default.
- W2032717282 hasConcept C80161118 @default.
- W2032717282 hasConcept C83730767 @default.
- W2032717282 hasConcept C86803240 @default.
- W2032717282 hasConcept C9224880 @default.
- W2032717282 hasConcept C95444343 @default.
- W2032717282 hasConceptScore W2032717282C104292427 @default.
- W2032717282 hasConceptScore W2032717282C104317684 @default.
- W2032717282 hasConceptScore W2032717282C126322002 @default.
- W2032717282 hasConceptScore W2032717282C134018914 @default.