Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032722330> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2032722330 endingPage "366" @default.
- W2032722330 startingPage "363" @default.
- W2032722330 abstract "Male gender and family history are risk factors for abdominal aortic aneurysm (AAA). We hypothesized that genes involved in sex hormones might be important in AAA. We investigated the association of aortic diameter with single-nucleotide polymorphisms (SNPs) in genes determining circulating sex hormones and their action. We genotyped 74 tagging SNPs across four genes (steroid 5α reductase, subfamily A, polypeptide 1 (SRD5A1), cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), androgen receptor (AR) and estrogen receptor 2 (ESR2)) related to sex hormone production and action in 1711 men, 640 of whom had an AAA. One genotype was also assessed in an independent cohort of 782 men, of whom 513 had large AAAs. Associations were assessed adjusting for other risk factors for AAA. One SNP in CYP19A1 was strongly associated with aortic diameter. Subjects who had the rare homozygote genotype (TT) for CYP19A1g.49412370C>T (SNP ID rs1961177), had an increased aortic diameter (coefficient 5.058, SE 1.394, P=0.0003, under a recessive model). This SNP was not associated with aortic diameter in an independent cohort, which included patients with larger AAAs. Our findings do not support an important role of genetic polymorphisms in genes determining sex hormones in aortic dilatation in men. The association of one SNP in CYPA9A1 with small but not large AAA may suggest differences between AAA formation and progression. This SNP warrants further investigation in another large population, including patients with small AAAs." @default.
- W2032722330 created "2016-06-24" @default.
- W2032722330 creator A5005641485 @default.
- W2032722330 creator A5012213444 @default.
- W2032722330 creator A5030805050 @default.
- W2032722330 creator A5036671564 @default.
- W2032722330 creator A5047193815 @default.
- W2032722330 creator A5050475981 @default.
- W2032722330 creator A5051426823 @default.
- W2032722330 creator A5076250987 @default.
- W2032722330 date "2010-12-01" @default.
- W2032722330 modified "2023-10-18" @default.
- W2032722330 title "A population-based study of polymorphisms in genes related to sex hormones and abdominal aortic aneurysm" @default.
- W2032722330 cites W1546778450 @default.
- W2032722330 cites W1981387277 @default.
- W2032722330 cites W2052522179 @default.
- W2032722330 cites W2059570306 @default.
- W2032722330 cites W2075756856 @default.
- W2032722330 cites W2119205818 @default.
- W2032722330 cites W2122450512 @default.
- W2032722330 cites W2146051938 @default.
- W2032722330 cites W2162530578 @default.
- W2032722330 cites W2164258641 @default.
- W2032722330 doi "https://doi.org/10.1038/ejhg.2010.182" @default.
- W2032722330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3062004" @default.
- W2032722330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21119710" @default.
- W2032722330 hasPublicationYear "2010" @default.
- W2032722330 type Work @default.
- W2032722330 sameAs 2032722330 @default.
- W2032722330 citedByCount "8" @default.
- W2032722330 countsByYear W20327223302014 @default.
- W2032722330 countsByYear W20327223302015 @default.
- W2032722330 countsByYear W20327223302021 @default.
- W2032722330 crossrefType "journal-article" @default.
- W2032722330 hasAuthorship W2032722330A5005641485 @default.
- W2032722330 hasAuthorship W2032722330A5012213444 @default.
- W2032722330 hasAuthorship W2032722330A5030805050 @default.
- W2032722330 hasAuthorship W2032722330A5036671564 @default.
- W2032722330 hasAuthorship W2032722330A5047193815 @default.
- W2032722330 hasAuthorship W2032722330A5050475981 @default.
- W2032722330 hasAuthorship W2032722330A5051426823 @default.
- W2032722330 hasAuthorship W2032722330A5076250987 @default.
- W2032722330 hasBestOaLocation W20327223301 @default.
- W2032722330 hasConcept C104317684 @default.
- W2032722330 hasConcept C126322002 @default.
- W2032722330 hasConcept C134018914 @default.
- W2032722330 hasConcept C135763542 @default.
- W2032722330 hasConcept C139275648 @default.
- W2032722330 hasConcept C141071460 @default.
- W2032722330 hasConcept C153209595 @default.
- W2032722330 hasConcept C2776098176 @default.
- W2032722330 hasConcept C2779993416 @default.
- W2032722330 hasConcept C2908647359 @default.
- W2032722330 hasConcept C54355233 @default.
- W2032722330 hasConcept C71924100 @default.
- W2032722330 hasConcept C86803240 @default.
- W2032722330 hasConcept C99454951 @default.
- W2032722330 hasConceptScore W2032722330C104317684 @default.
- W2032722330 hasConceptScore W2032722330C126322002 @default.
- W2032722330 hasConceptScore W2032722330C134018914 @default.
- W2032722330 hasConceptScore W2032722330C135763542 @default.
- W2032722330 hasConceptScore W2032722330C139275648 @default.
- W2032722330 hasConceptScore W2032722330C141071460 @default.
- W2032722330 hasConceptScore W2032722330C153209595 @default.
- W2032722330 hasConceptScore W2032722330C2776098176 @default.
- W2032722330 hasConceptScore W2032722330C2779993416 @default.
- W2032722330 hasConceptScore W2032722330C2908647359 @default.
- W2032722330 hasConceptScore W2032722330C54355233 @default.
- W2032722330 hasConceptScore W2032722330C71924100 @default.
- W2032722330 hasConceptScore W2032722330C86803240 @default.
- W2032722330 hasConceptScore W2032722330C99454951 @default.
- W2032722330 hasIssue "3" @default.
- W2032722330 hasLocation W20327223301 @default.
- W2032722330 hasLocation W20327223302 @default.
- W2032722330 hasLocation W20327223303 @default.
- W2032722330 hasLocation W20327223304 @default.
- W2032722330 hasLocation W20327223305 @default.
- W2032722330 hasOpenAccess W2032722330 @default.
- W2032722330 hasPrimaryLocation W20327223301 @default.
- W2032722330 hasRelatedWork W1511048503 @default.
- W2032722330 hasRelatedWork W1663907732 @default.
- W2032722330 hasRelatedWork W1984103522 @default.
- W2032722330 hasRelatedWork W2056355462 @default.
- W2032722330 hasRelatedWork W2283861756 @default.
- W2032722330 hasRelatedWork W2358154819 @default.
- W2032722330 hasRelatedWork W2382289467 @default.
- W2032722330 hasRelatedWork W2790470715 @default.
- W2032722330 hasRelatedWork W3030331178 @default.
- W2032722330 hasRelatedWork W3177672991 @default.
- W2032722330 hasVolume "19" @default.
- W2032722330 isParatext "false" @default.
- W2032722330 isRetracted "false" @default.
- W2032722330 magId "2032722330" @default.
- W2032722330 workType "article" @default.