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- W2032733696 abstract "Traumatic subarachnoid haemorrhage is a common finding in all degrees of severity of head injury and is an independent predictor of poor outcome. 1 Wardlaw JM Easton VJ Statham P Which CT features help predict outcome after head injury?. J Neurol Neurosurg Psychiatry. 2002; 72: 188-192 Crossref PubMed Scopus (98) Google Scholar However, to what extent the presence of subarachnoid blood contributes to secondary deterioration or whether this is simply an epiphenomenon of the injury is unclear. In patients with aneurysmal subarachnoid haemorrhage nimodipine is widely used for the prevention and treatment of cerebral vasospasm, a major contributor to morbidity and mortality in this disorder. Although the main effect of nimodipine is thought to be relaxation of the smooth muscle of the cerebral vasculature mediated by its Ca2+ antagonistic action, other mechanisms have been invoked, including possible antioxidant activity. 2 Ercan M Inci S Kilinc K Palaoglu S Aypar U Nimodipine attenuates lipid peroxidation during the acute phase of head trauma in rats. Neurosurg Rev. 2001; 24: 127-130 Crossref PubMed Scopus (28) Google Scholar Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage: a systematic reviewOur results do not lend support to the finding of a beneficial effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage as reported in an earlier Cochrane review. Full-Text PDF ErrataSen J, Belli A. Nimodipine for subarachnoid haemorrhage: the end of the road or better trials? Lancet Neurol 2006; 5: 993–94. The title of this Reflection and Reaction article should have read “Nimodipine for traumatic subarachnoid haemorrhage: the end of the road or better trials?” Full-Text PDF" @default.
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- W2032733696 title "Nimodipine for subarachnoid haemorrhage: the end of the road or better trials?" @default.
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- W2032733696 doi "https://doi.org/10.1016/s1474-4422(06)70583-x" @default.
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