FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032743504> ?p ?o ?g. }

• W2032743504 endingPage "358" @default.
• W2032743504 startingPage "353" @default.
• W2032743504 abstract "To clarify the role of intercellular communication in the liver during accumulation of neutrophils, the release of cytokine-induced neutrophil chemoattractant (CINC) (interleukin-8 [IL-8] related protein in rodents) by hepatocytes was investigated in the presence of Kupffer cell-conditioned medium in vitro. Kupffer cells were prepared by perfusion of rat liver with collagenase followed by centrifugation on a metrizamide gradient and were cultured in the presence or absence of lipopolysacharide (LPS). The conditioned medium was collected after 24 hours, and rat hepatocytes were cultured in the presence or absence of Kupffer cell-conditioned medium. An amount of CINC in the culture supernatant was measured by western blotting analysis and enzyme-linked immunosorbent assay (ELISA), and expression of its messenger RNA (mRNA) was assessed by the polymerase chain reaction. LPS-stimulated Kupffer cell-conditioned medium enhanced an expression of CINC mRNA in hepatocytes and increased the production of CINC by hepatocytes. Enhanced production of CINC was not shown when the Kupffer cell-conditioned medium was pretreated with heat (56 degrees C, 30 minutes). The production of CINC by hepatocytes in the presence of the LPS-stimulated Kupffer cell-conditioned medium was reduced by an antibody against interleukin 1 beta (IL-1 beta), but not by antibodies against tumor necrosis factor alpha (TNF-alpha) or LPS. These results suggest that production of CINC by hepatocytes could be regulated by IL-1 beta released from Kupffer cells, leading to neutrophil accumulation during liver injury, because this protein is a strong chemoattractant for neutrophils." @default.
• W2032743504 created "2016-06-24" @default.
• W2032743504 creator A5005637906 @default.
• W2032743504 creator A5006352738 @default.
• W2032743504 creator A5008284167 @default.
• W2032743504 creator A5015091413 @default.
• W2032743504 creator A5016469221 @default.
• W2032743504 creator A5023823880 @default.
• W2032743504 creator A5024245013 @default.
• W2032743504 creator A5033578823 @default.
• W2032743504 creator A5034244372 @default.
• W2032743504 creator A5046986007 @default.
• W2032743504 date "1996-02-01" @default.
• W2032743504 modified "2023-10-18" @default.
• W2032743504 title "Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells" @default.
• W2032743504 cites W2123228131 @default.
• W2032743504 cites W2403091482 @default.
• W2032743504 doi "https://doi.org/10.1002/hep.510230223" @default.
• W2032743504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8591863" @default.
• W2032743504 hasPublicationYear "1996" @default.
• W2032743504 type Work @default.
• W2032743504 sameAs 2032743504 @default.
• W2032743504 citedByCount "58" @default.
• W2032743504 countsByYear W20327435042012 @default.
• W2032743504 countsByYear W20327435042017 @default.
• W2032743504 countsByYear W20327435042018 @default.
• W2032743504 countsByYear W20327435042019 @default.
• W2032743504 crossrefType "journal-article" @default.
• W2032743504 hasAuthorship W2032743504A5005637906 @default.
• W2032743504 hasAuthorship W2032743504A5006352738 @default.
• W2032743504 hasAuthorship W2032743504A5008284167 @default.
• W2032743504 hasAuthorship W2032743504A5015091413 @default.
• W2032743504 hasAuthorship W2032743504A5016469221 @default.
• W2032743504 hasAuthorship W2032743504A5023823880 @default.
• W2032743504 hasAuthorship W2032743504A5024245013 @default.
• W2032743504 hasAuthorship W2032743504A5033578823 @default.
• W2032743504 hasAuthorship W2032743504A5034244372 @default.
• W2032743504 hasAuthorship W2032743504A5046986007 @default.
• W2032743504 hasConcept C134018914 @default.
• W2032743504 hasConcept C153911025 @default.
• W2032743504 hasConcept C170493617 @default.
• W2032743504 hasConcept C17991360 @default.
• W2032743504 hasConcept C181199279 @default.
• W2032743504 hasConcept C185592680 @default.
• W2032743504 hasConcept C195521686 @default.
• W2032743504 hasConcept C198677920 @default.
• W2032743504 hasConcept C202751555 @default.
• W2032743504 hasConcept C203014093 @default.
• W2032743504 hasConcept C2776200302 @default.
• W2032743504 hasConcept C2776637226 @default.
• W2032743504 hasConcept C2776914184 @default.
• W2032743504 hasConcept C2778394429 @default.
• W2032743504 hasConcept C2778690821 @default.
• W2032743504 hasConcept C2778904781 @default.
• W2032743504 hasConcept C2908801736 @default.
• W2032743504 hasConcept C54166955 @default.
• W2032743504 hasConcept C55493867 @default.
• W2032743504 hasConcept C68324877 @default.
• W2032743504 hasConcept C86803240 @default.
• W2032743504 hasConceptScore W2032743504C134018914 @default.
• W2032743504 hasConceptScore W2032743504C153911025 @default.
• W2032743504 hasConceptScore W2032743504C170493617 @default.
• W2032743504 hasConceptScore W2032743504C17991360 @default.
• W2032743504 hasConceptScore W2032743504C181199279 @default.
• W2032743504 hasConceptScore W2032743504C185592680 @default.
• W2032743504 hasConceptScore W2032743504C195521686 @default.
• W2032743504 hasConceptScore W2032743504C198677920 @default.
• W2032743504 hasConceptScore W2032743504C202751555 @default.
• W2032743504 hasConceptScore W2032743504C203014093 @default.
• W2032743504 hasConceptScore W2032743504C2776200302 @default.
• W2032743504 hasConceptScore W2032743504C2776637226 @default.
• W2032743504 hasConceptScore W2032743504C2776914184 @default.
• W2032743504 hasConceptScore W2032743504C2778394429 @default.
• W2032743504 hasConceptScore W2032743504C2778690821 @default.
• W2032743504 hasConceptScore W2032743504C2778904781 @default.
• W2032743504 hasConceptScore W2032743504C2908801736 @default.
• W2032743504 hasConceptScore W2032743504C54166955 @default.
• W2032743504 hasConceptScore W2032743504C55493867 @default.
• W2032743504 hasConceptScore W2032743504C68324877 @default.
• W2032743504 hasConceptScore W2032743504C86803240 @default.
• W2032743504 hasIssue "2" @default.
• W2032743504 hasLocation W20327435041 @default.
• W2032743504 hasLocation W20327435042 @default.
• W2032743504 hasOpenAccess W2032743504 @default.
• W2032743504 hasPrimaryLocation W20327435041 @default.
• W2032743504 hasRelatedWork W1495743471 @default.
• W2032743504 hasRelatedWork W1985286395 @default.
• W2032743504 hasRelatedWork W2016440344 @default.
• W2032743504 hasRelatedWork W2032743504 @default.
• W2032743504 hasRelatedWork W2046779380 @default.
• W2032743504 hasRelatedWork W2067566445 @default.
• W2032743504 hasRelatedWork W2149826057 @default.
• W2032743504 hasRelatedWork W2374532081 @default.
• W2032743504 hasRelatedWork W2393219483 @default.
• W2032743504 hasRelatedWork W328665885 @default.
• W2032743504 hasVolume "23" @default.
• W2032743504 isParatext "false" @default.
• W2032743504 isRetracted "false" @default.

• next