FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032750779> ?p ?o ?g. }

• W2032750779 endingPage "3631" @default.
• W2032750779 startingPage "3627" @default.
• W2032750779 abstract "A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research, heterocycle-containing tethers were explored with the intent to further improve potency and minimize hERG liabilities. This effort culminated in the discovery of compound 10, which efficiently suppressed proliferation of HCT116 and U87 cells. This compound showed prolonged Hsp90-inhibitory activity at least 24 h post-administration consistent with elevated and prolonged exposure in the tumor. When studied in a xenograft model, the compound demonstrated significant suppression of tumor growth." @default.
• W2032750779 created "2016-06-24" @default.
• W2032750779 creator A5004255314 @default.
• W2032750779 creator A5006212293 @default.
• W2032750779 creator A5011808781 @default.
• W2032750779 creator A5015056019 @default.
• W2032750779 creator A5042956548 @default.
• W2032750779 creator A5066673243 @default.
• W2032750779 creator A5080525415 @default.
• W2032750779 creator A5088664989 @default.
• W2032750779 creator A5088673257 @default.
• W2032750779 creator A5090979481 @default.
• W2032750779 date "2011-06-01" @default.
• W2032750779 modified "2023-09-28" @default.
• W2032750779 title "Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model" @default.
• W2032750779 cites W1964826325 @default.
• W2032750779 cites W1966229978 @default.
• W2032750779 cites W1968916175 @default.
• W2032750779 cites W1969855931 @default.
• W2032750779 cites W1978181461 @default.
• W2032750779 cites W1995007645 @default.
• W2032750779 cites W1998233841 @default.
• W2032750779 cites W1999715990 @default.
• W2032750779 cites W2007106751 @default.
• W2032750779 cites W2009899654 @default.
• W2032750779 cites W2022234086 @default.
• W2032750779 cites W2022531767 @default.
• W2032750779 cites W2023018411 @default.
• W2032750779 cites W2027770426 @default.
• W2032750779 cites W2044774111 @default.
• W2032750779 cites W2059367931 @default.
• W2032750779 cites W2059716720 @default.
• W2032750779 cites W2063013379 @default.
• W2032750779 cites W2063488126 @default.
• W2032750779 cites W2082390299 @default.
• W2032750779 cites W2082474121 @default.
• W2032750779 cites W2086435172 @default.
• W2032750779 cites W2095718201 @default.
• W2032750779 cites W2111187586 @default.
• W2032750779 cites W2119790759 @default.
• W2032750779 cites W2126371858 @default.
• W2032750779 cites W2147438004 @default.
• W2032750779 cites W2159304778 @default.
• W2032750779 cites W2951057995 @default.
• W2032750779 doi "https://doi.org/10.1016/j.bmcl.2011.04.102" @default.
• W2032750779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21605975" @default.
• W2032750779 hasPublicationYear "2011" @default.
• W2032750779 type Work @default.
• W2032750779 sameAs 2032750779 @default.
• W2032750779 citedByCount "18" @default.
• W2032750779 countsByYear W20327507792012 @default.
• W2032750779 countsByYear W20327507792013 @default.
• W2032750779 countsByYear W20327507792014 @default.
• W2032750779 countsByYear W20327507792015 @default.
• W2032750779 countsByYear W20327507792017 @default.
• W2032750779 countsByYear W20327507792018 @default.
• W2032750779 countsByYear W20327507792019 @default.
• W2032750779 countsByYear W20327507792020 @default.
• W2032750779 countsByYear W20327507792021 @default.
• W2032750779 crossrefType "journal-article" @default.
• W2032750779 hasAuthorship W2032750779A5004255314 @default.
• W2032750779 hasAuthorship W2032750779A5006212293 @default.
• W2032750779 hasAuthorship W2032750779A5011808781 @default.
• W2032750779 hasAuthorship W2032750779A5015056019 @default.
• W2032750779 hasAuthorship W2032750779A5042956548 @default.
• W2032750779 hasAuthorship W2032750779A5066673243 @default.
• W2032750779 hasAuthorship W2032750779A5080525415 @default.
• W2032750779 hasAuthorship W2032750779A5088664989 @default.
• W2032750779 hasAuthorship W2032750779A5088673257 @default.
• W2032750779 hasAuthorship W2032750779A5090979481 @default.
• W2032750779 hasConcept C104317684 @default.
• W2032750779 hasConcept C12554922 @default.
• W2032750779 hasConcept C150903083 @default.
• W2032750779 hasConcept C185592680 @default.
• W2032750779 hasConcept C193042331 @default.
• W2032750779 hasConcept C202751555 @default.
• W2032750779 hasConcept C205260736 @default.
• W2032750779 hasConcept C207001950 @default.
• W2032750779 hasConcept C26291073 @default.
• W2032750779 hasConcept C2775932338 @default.
• W2032750779 hasConcept C2779362680 @default.
• W2032750779 hasConcept C55493867 @default.
• W2032750779 hasConcept C57992300 @default.
• W2032750779 hasConcept C71240020 @default.
• W2032750779 hasConcept C83743174 @default.
• W2032750779 hasConcept C86803240 @default.
• W2032750779 hasConcept C98274493 @default.
• W2032750779 hasConceptScore W2032750779C104317684 @default.
• W2032750779 hasConceptScore W2032750779C12554922 @default.
• W2032750779 hasConceptScore W2032750779C150903083 @default.
• W2032750779 hasConceptScore W2032750779C185592680 @default.
• W2032750779 hasConceptScore W2032750779C193042331 @default.
• W2032750779 hasConceptScore W2032750779C202751555 @default.
• W2032750779 hasConceptScore W2032750779C205260736 @default.
• W2032750779 hasConceptScore W2032750779C207001950 @default.
• W2032750779 hasConceptScore W2032750779C26291073 @default.
• W2032750779 hasConceptScore W2032750779C2775932338 @default.
• W2032750779 hasConceptScore W2032750779C2779362680 @default.

• next