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• W2032754080 abstract "Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD+. The function of PARP-1 is related to important nuclear processes including DNA repair and transcription. Previous studies demonstrated a specific physical interaction between PARP-1 and the transcription factor Yin Yang 1 (YY1) in vitro. In this study, a functional relationship between both proteins in response to genotoxic treatment of cells is presented. The interaction of YY1 with PARP-1 greatly stimulates the enzymatic activity of PARP-1. Consistent with this, the overexpression of YY1 in HeLa cells resulted in an enhanced synthesis of poly(ADP-ribose) and an acceleration of DNA repair in response to a treatment with methyl-N′-nitro-N′-nitrosoguanidine." @default.
• W2032754080 created "2016-06-24" @default.
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• W2032754080 date "2001-06-01" @default.
• W2032754080 modified "2023-10-17" @default.
• W2032754080 title "Transcription Factor Yin Yang 1 Stimulates Poly(ADP-Ribosyl)ation and DNA Repair" @default.
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• W2032754080 doi "https://doi.org/10.1006/bbrc.2001.4985" @default.
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