FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032755732> ?p ?o ?g. }

• W2032755732 endingPage "3115" @default.
• W2032755732 startingPage "3109" @default.
• W2032755732 abstract "To enhance the outstanding biological response shown by the corresponding monomers 4 and 5, two classes of bis-acridine-4-carboxamides, 9, with a linker between the 4,4' positions, and 13, with a linker between the 1,1' positions, have been prepared as DNA-binding and potential antitumor agents. The noncovalent DNA-binding properties of these compounds have been examined using gel-electrophoresis and fluorometric techniques. The results indicate that (i). target compounds intercalate DNA; (ii). the bis derivatives with the optimal linker are considerably more DNA-affinic than corresponding monomers; (iii). overall affinity is sensitive to the nature of the linker, of the chromophores, and of the substituents at 7,7'; (iv). often, the bis derivatives show a marked AT-preferential binding. In vitro cytotoxic potency of these derivatives toward the human colon adenocarcinoma cell line (HT29) is described and compared to that of reference drugs. Structure-activity relationships are discussed. Some highly DNA-affinic and potent cytotoxic compounds, 9b,f and 13b,c, have been selected for the National Cancer Institute (NCI) screening on 60 human tumor cell lines and identified as new leads in the antitumor strategies." @default.
• W2032755732 created "2016-06-24" @default.
• W2032755732 creator A5001638640 @default.
• W2032755732 creator A5015945355 @default.
• W2032755732 creator A5023401629 @default.
• W2032755732 creator A5034449680 @default.
• W2032755732 creator A5062567262 @default.
• W2032755732 creator A5062668777 @default.
• W2032755732 creator A5073098876 @default.
• W2032755732 creator A5088792877 @default.
• W2032755732 date "2003-06-07" @default.
• W2032755732 modified "2023-10-02" @default.
• W2032755732 title "Design, Synthesis, and Biological Properties of New Bis(acridine-4-carboxamides) as Anticancer Agents" @default.
• W2032755732 cites W2008889418 @default.
• W2032755732 cites W2016033382 @default.
• W2032755732 cites W2018236972 @default.
• W2032755732 cites W2034660754 @default.
• W2032755732 cites W2041516742 @default.
• W2032755732 cites W2068842413 @default.
• W2032755732 cites W2086384710 @default.
• W2032755732 cites W2141794306 @default.
• W2032755732 cites W2950740969 @default.
• W2032755732 cites W2950938499 @default.
• W2032755732 cites W2951851972 @default.
• W2032755732 doi "https://doi.org/10.1021/jm030820x" @default.
• W2032755732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12825949" @default.
• W2032755732 hasPublicationYear "2003" @default.
• W2032755732 type Work @default.
• W2032755732 sameAs 2032755732 @default.
• W2032755732 citedByCount "51" @default.
• W2032755732 countsByYear W20327557322012 @default.
• W2032755732 countsByYear W20327557322013 @default.
• W2032755732 countsByYear W20327557322015 @default.
• W2032755732 countsByYear W20327557322016 @default.
• W2032755732 countsByYear W20327557322017 @default.
• W2032755732 countsByYear W20327557322018 @default.
• W2032755732 countsByYear W20327557322019 @default.
• W2032755732 countsByYear W20327557322020 @default.
• W2032755732 countsByYear W20327557322021 @default.
• W2032755732 countsByYear W20327557322022 @default.
• W2032755732 countsByYear W20327557322023 @default.
• W2032755732 crossrefType "journal-article" @default.
• W2032755732 hasAuthorship W2032755732A5001638640 @default.
• W2032755732 hasAuthorship W2032755732A5015945355 @default.
• W2032755732 hasAuthorship W2032755732A5023401629 @default.
• W2032755732 hasAuthorship W2032755732A5034449680 @default.
• W2032755732 hasAuthorship W2032755732A5062567262 @default.
• W2032755732 hasAuthorship W2032755732A5062668777 @default.
• W2032755732 hasAuthorship W2032755732A5073098876 @default.
• W2032755732 hasAuthorship W2032755732A5088792877 @default.
• W2032755732 hasConcept C111919701 @default.
• W2032755732 hasConcept C116073593 @default.
• W2032755732 hasConcept C137824038 @default.
• W2032755732 hasConcept C166940927 @default.
• W2032755732 hasConcept C178790620 @default.
• W2032755732 hasConcept C185592680 @default.
• W2032755732 hasConcept C192468462 @default.
• W2032755732 hasConcept C202751555 @default.
• W2032755732 hasConcept C21951064 @default.
• W2032755732 hasConcept C2776924795 @default.
• W2032755732 hasConcept C2780557392 @default.
• W2032755732 hasConcept C41008148 @default.
• W2032755732 hasConcept C521977710 @default.
• W2032755732 hasConcept C552990157 @default.
• W2032755732 hasConcept C55493867 @default.
• W2032755732 hasConcept C71240020 @default.
• W2032755732 hasConceptScore W2032755732C111919701 @default.
• W2032755732 hasConceptScore W2032755732C116073593 @default.
• W2032755732 hasConceptScore W2032755732C137824038 @default.
• W2032755732 hasConceptScore W2032755732C166940927 @default.
• W2032755732 hasConceptScore W2032755732C178790620 @default.
• W2032755732 hasConceptScore W2032755732C185592680 @default.
• W2032755732 hasConceptScore W2032755732C192468462 @default.
• W2032755732 hasConceptScore W2032755732C202751555 @default.
• W2032755732 hasConceptScore W2032755732C21951064 @default.
• W2032755732 hasConceptScore W2032755732C2776924795 @default.
• W2032755732 hasConceptScore W2032755732C2780557392 @default.
• W2032755732 hasConceptScore W2032755732C41008148 @default.
• W2032755732 hasConceptScore W2032755732C521977710 @default.
• W2032755732 hasConceptScore W2032755732C552990157 @default.
• W2032755732 hasConceptScore W2032755732C55493867 @default.
• W2032755732 hasConceptScore W2032755732C71240020 @default.
• W2032755732 hasIssue "14" @default.
• W2032755732 hasLocation W20327557321 @default.
• W2032755732 hasLocation W20327557322 @default.
• W2032755732 hasOpenAccess W2032755732 @default.
• W2032755732 hasPrimaryLocation W20327557321 @default.
• W2032755732 hasRelatedWork W1498354524 @default.
• W2032755732 hasRelatedWork W1979799922 @default.
• W2032755732 hasRelatedWork W1981939135 @default.
• W2032755732 hasRelatedWork W2006543080 @default.
• W2032755732 hasRelatedWork W2076260856 @default.
• W2032755732 hasRelatedWork W2085028575 @default.
• W2032755732 hasRelatedWork W2414084544 @default.
• W2032755732 hasRelatedWork W2745426438 @default.
• W2032755732 hasRelatedWork W2950730676 @default.
• W2032755732 hasRelatedWork W2183188049 @default.
• W2032755732 hasVolume "46" @default.

• next