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• W2032761552 abstract "Abstract A series of 1‐arylsulfonyl‐5‐( N ‐hydroxyacrylamide)indolines ( 7 – 15 ) has been developed; the compounds exhibited potent histone deacetylase (HDAC) inhibitory activities. Notably, almost all of this series exhibited better HDAC‐inhibitory and antiproliferative activities than 3‐(1‐benzenesulfonyl‐1 H ‐indol‐5‐yl)‐ N ‐hydroxyacrylamide ( 6 ), as reported in a previous study. Among these compounds, 3‐[1‐(4‐methoxybenzenesulfonyl)‐2,3‐dihydro‐1 H ‐indol‐5‐yl]‐ N ‐hydroxyacrylamide ( 9 ) showed a two‐ to tenfold increase in activity compared to SAHA ( 1 ) in the suppression of lipopolysaccharide‐induced cytokine production. Compound 9 also caused a marked reduction in carrageenan‐induced acute inflammation in a rat model. Taken together, these data indicated that 1‐arylsulfonyl‐5‐( N ‐hydroxyacrylamide)indolines HDAC inhibitors exhibit potent anti‐inflammatory activity." @default.
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• W2032761552 date "2013-06-20" @default.
• W2032761552 modified "2023-10-17" @default.
• W2032761552 title "1-Arylsulfonyl-5-(<i>N</i>-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors" @default.
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• W2032761552 doi "https://doi.org/10.1002/cbic.201300201" @default.
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