Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032781690> ?p ?o ?g. }
- W2032781690 endingPage "1187" @default.
- W2032781690 startingPage "1175" @default.
- W2032781690 abstract "The discovery and increased understanding of tumor targets has led to the development and approval of 12 small molecule tyrosine kinase inhibitors (TKIs). Despite tremendous efforts in TKI development, treatment efficacies with these therapeutics are still too low and improvements require a personalized medicine approach. Positron emission tomography (PET) with radiolabeled TKIs (TKI-PET) is a tracking, quantification and imaging method, which provides a unique understanding of the behavior of these drugs in vivo and of the interaction with their target(s). In this article we provide an overview of tracer synthesis and development because each TKI requires a tailor made approach. Moreover, we describe current preclinical work and the first proof-of-principle clinical studies on the application of TKI-PET, illustrating the potential of this approach for improving therapy efficacy and personalized cancer treatment." @default.
- W2032781690 created "2016-06-24" @default.
- W2032781690 creator A5003445744 @default.
- W2032781690 creator A5042792515 @default.
- W2032781690 creator A5064942395 @default.
- W2032781690 creator A5089089705 @default.
- W2032781690 date "2012-11-01" @default.
- W2032781690 modified "2023-09-27" @default.
- W2032781690 title "PET imaging with small-molecule tyrosine kinase inhibitors: TKI-PET" @default.
- W2032781690 cites W1608167574 @default.
- W2032781690 cites W1619850371 @default.
- W2032781690 cites W1639582946 @default.
- W2032781690 cites W1963561520 @default.
- W2032781690 cites W1964889141 @default.
- W2032781690 cites W1974903851 @default.
- W2032781690 cites W1977332018 @default.
- W2032781690 cites W1997533142 @default.
- W2032781690 cites W1999868376 @default.
- W2032781690 cites W2000906632 @default.
- W2032781690 cites W2002269715 @default.
- W2032781690 cites W2007180745 @default.
- W2032781690 cites W2008940139 @default.
- W2032781690 cites W2013784863 @default.
- W2032781690 cites W2016710415 @default.
- W2032781690 cites W2023493888 @default.
- W2032781690 cites W2024529045 @default.
- W2032781690 cites W2034070721 @default.
- W2032781690 cites W2034129064 @default.
- W2032781690 cites W2034190722 @default.
- W2032781690 cites W2035777071 @default.
- W2032781690 cites W2043696829 @default.
- W2032781690 cites W2046450888 @default.
- W2032781690 cites W2047457899 @default.
- W2032781690 cites W2061345986 @default.
- W2032781690 cites W2061349611 @default.
- W2032781690 cites W2062366098 @default.
- W2032781690 cites W2071374099 @default.
- W2032781690 cites W2071609512 @default.
- W2032781690 cites W2076174476 @default.
- W2032781690 cites W2076372887 @default.
- W2032781690 cites W2076601396 @default.
- W2032781690 cites W2080389460 @default.
- W2032781690 cites W2085254573 @default.
- W2032781690 cites W2091711716 @default.
- W2032781690 cites W2093151618 @default.
- W2032781690 cites W2093614047 @default.
- W2032781690 cites W2095406737 @default.
- W2032781690 cites W2100066495 @default.
- W2032781690 cites W2103705313 @default.
- W2032781690 cites W2109897091 @default.
- W2032781690 cites W2114514158 @default.
- W2032781690 cites W2124524221 @default.
- W2032781690 cites W2125640764 @default.
- W2032781690 cites W2126162318 @default.
- W2032781690 cites W2127405341 @default.
- W2032781690 cites W2129787264 @default.
- W2032781690 cites W2137082827 @default.
- W2032781690 cites W2138297714 @default.
- W2032781690 cites W2139236349 @default.
- W2032781690 cites W2145036848 @default.
- W2032781690 cites W2146595692 @default.
- W2032781690 cites W2149792725 @default.
- W2032781690 cites W2151618742 @default.
- W2032781690 cites W2153331460 @default.
- W2032781690 cites W2157723462 @default.
- W2032781690 cites W2159013299 @default.
- W2032781690 cites W2161821474 @default.
- W2032781690 cites W2162525969 @default.
- W2032781690 cites W2163860474 @default.
- W2032781690 cites W2168780223 @default.
- W2032781690 cites W2366411924 @default.
- W2032781690 cites W4238271314 @default.
- W2032781690 doi "https://doi.org/10.1016/j.drudis.2012.06.016" @default.
- W2032781690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22766374" @default.
- W2032781690 hasPublicationYear "2012" @default.
- W2032781690 type Work @default.
- W2032781690 sameAs 2032781690 @default.
- W2032781690 citedByCount "62" @default.
- W2032781690 countsByYear W20327816902012 @default.
- W2032781690 countsByYear W20327816902013 @default.
- W2032781690 countsByYear W20327816902014 @default.
- W2032781690 countsByYear W20327816902015 @default.
- W2032781690 countsByYear W20327816902016 @default.
- W2032781690 countsByYear W20327816902017 @default.
- W2032781690 countsByYear W20327816902018 @default.
- W2032781690 countsByYear W20327816902019 @default.
- W2032781690 countsByYear W20327816902020 @default.
- W2032781690 countsByYear W20327816902021 @default.
- W2032781690 countsByYear W20327816902022 @default.
- W2032781690 countsByYear W20327816902023 @default.
- W2032781690 crossrefType "journal-article" @default.
- W2032781690 hasAuthorship W2032781690A5003445744 @default.
- W2032781690 hasAuthorship W2032781690A5042792515 @default.
- W2032781690 hasAuthorship W2032781690A5064942395 @default.
- W2032781690 hasAuthorship W2032781690A5089089705 @default.
- W2032781690 hasConcept C121608353 @default.
- W2032781690 hasConcept C126322002 @default.
- W2032781690 hasConcept C136339569 @default.