Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032783309> ?p ?o ?g. }
- W2032783309 endingPage "955" @default.
- W2032783309 startingPage "939" @default.
- W2032783309 abstract "Oxytocin is a potent inducer of penile erection when injected into the central nervous system. In male rats, the most sensitive brain area for the pro-erectile effect of oxytocin is the paraventricular nucleus of the hypothalamus. This nucleus and surrounding regions contain the cell bodies of all oxytocinergic neurons projecting to extra-hypothalamic brain areas and the spinal cord. This review shows that oxytocin induces penile erection also when injected in some of these areas (e.g., ventral tegmental area, ventral subiculum of the hippocampus, posteromedial cortical nucleus of the amygdala and thoraco-lumbar spinal cord). Microinjection studies combined with intra-cerebral microdialysis and double immuno-fluorescence studies suggest that oxytocin in these areas activates directly or indirectly (mainly through glutamic acid) mesolimbic dopaminergic neurons. Dopamine released in the nucleus accumbens in turn activates neural pathways leading to the activation of incerto-hypothalamic dopaminergic neurons in the paraventricular nucleus. This activates not only oxytocinergic neurons projecting to the spinal cord and mediating penile erection, but also those projecting to the above extra-hypothalamic areas, modulating directly or indirectly (through glutamic acid) the activity of mesolimbic dopaminergic neurons controlling motivation and reward. Together these neural pathways may constitute a complex hypothetical circuit, which plays a role not only in the consummatory phase of sexual activity (erectile function and copulation), but also in the motivational and rewarding aspects of the anticipatory phase of sexual behaviour." @default.
- W2032783309 created "2016-06-24" @default.
- W2032783309 creator A5030721300 @default.
- W2032783309 creator A5053468603 @default.
- W2032783309 date "2011-01-01" @default.
- W2032783309 modified "2023-10-13" @default.
- W2032783309 title "Central control of penile erection: A re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid in male rats" @default.
- W2032783309 cites W1592574065 @default.
- W2032783309 cites W1762890213 @default.
- W2032783309 cites W1801993555 @default.
- W2032783309 cites W1964581086 @default.
- W2032783309 cites W1965670118 @default.
- W2032783309 cites W1965679449 @default.
- W2032783309 cites W1965787766 @default.
- W2032783309 cites W1966211113 @default.
- W2032783309 cites W1969205984 @default.
- W2032783309 cites W1970313199 @default.
- W2032783309 cites W1970577797 @default.
- W2032783309 cites W1970747872 @default.
- W2032783309 cites W1972389227 @default.
- W2032783309 cites W1974810455 @default.
- W2032783309 cites W1979521526 @default.
- W2032783309 cites W1981979601 @default.
- W2032783309 cites W1984418460 @default.
- W2032783309 cites W1985146472 @default.
- W2032783309 cites W1985304019 @default.
- W2032783309 cites W1985321201 @default.
- W2032783309 cites W1985458200 @default.
- W2032783309 cites W1985671565 @default.
- W2032783309 cites W1986488682 @default.
- W2032783309 cites W1988974341 @default.
- W2032783309 cites W1989161294 @default.
- W2032783309 cites W1989818009 @default.
- W2032783309 cites W1993130604 @default.
- W2032783309 cites W1993142467 @default.
- W2032783309 cites W1993602309 @default.
- W2032783309 cites W1995418515 @default.
- W2032783309 cites W1998872047 @default.
- W2032783309 cites W2003845973 @default.
- W2032783309 cites W2003870238 @default.
- W2032783309 cites W2004297361 @default.
- W2032783309 cites W2004584514 @default.
- W2032783309 cites W2006327345 @default.
- W2032783309 cites W2006599923 @default.
- W2032783309 cites W2007526327 @default.
- W2032783309 cites W2008659300 @default.
- W2032783309 cites W2009178283 @default.
- W2032783309 cites W2010293262 @default.
- W2032783309 cites W2010624346 @default.
- W2032783309 cites W2011222672 @default.
- W2032783309 cites W2012169215 @default.
- W2032783309 cites W2014539594 @default.
- W2032783309 cites W2015594809 @default.
- W2032783309 cites W2016340279 @default.
- W2032783309 cites W2016542963 @default.
- W2032783309 cites W2018139815 @default.
- W2032783309 cites W2018203694 @default.
- W2032783309 cites W2019424197 @default.
- W2032783309 cites W2019811843 @default.
- W2032783309 cites W2021809633 @default.
- W2032783309 cites W2026250903 @default.
- W2032783309 cites W2027387190 @default.
- W2032783309 cites W2028405447 @default.
- W2032783309 cites W2029730501 @default.
- W2032783309 cites W2030685195 @default.
- W2032783309 cites W2031336666 @default.
- W2032783309 cites W2033322493 @default.
- W2032783309 cites W2033558463 @default.
- W2032783309 cites W2033944150 @default.
- W2032783309 cites W2034952552 @default.
- W2032783309 cites W2035261481 @default.
- W2032783309 cites W2035643315 @default.
- W2032783309 cites W2037482800 @default.
- W2032783309 cites W2038430188 @default.
- W2032783309 cites W2038978204 @default.
- W2032783309 cites W2039413967 @default.
- W2032783309 cites W2039443858 @default.
- W2032783309 cites W2042625808 @default.
- W2032783309 cites W2047473926 @default.
- W2032783309 cites W2049031495 @default.
- W2032783309 cites W2052730403 @default.
- W2032783309 cites W2053200829 @default.
- W2032783309 cites W2055365098 @default.
- W2032783309 cites W2055404539 @default.
- W2032783309 cites W2055927016 @default.
- W2032783309 cites W2056147576 @default.
- W2032783309 cites W2057135100 @default.
- W2032783309 cites W2057750894 @default.
- W2032783309 cites W2058172530 @default.
- W2032783309 cites W2058688700 @default.
- W2032783309 cites W2059297425 @default.
- W2032783309 cites W2060554066 @default.
- W2032783309 cites W2061627581 @default.
- W2032783309 cites W2063087114 @default.
- W2032783309 cites W2063857043 @default.
- W2032783309 cites W2066430700 @default.
- W2032783309 cites W2067121437 @default.
- W2032783309 cites W2067524792 @default.