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• W2032789281 endingPage "1192" @default.
• W2032789281 startingPage "1185" @default.
• W2032789281 abstract "The question under discussion is, “By what intracellular means does dietary cholesterol inhibit cholesterol synthesis in the liver?” This inhibition is known to occur primarily at the biosynthetic step catalysed by the microsomal enzyme, HMGR, i.e. β-hydroxy-β-methylglutaryl co-enzyme A reductase [mevalonate:NADP oxidoreductase (acylating CoA);EC.1.1.1.34]. In this review we propose and defend the hypothesis that, “The activity of hepatic HMGR is critically regulated by the fluidity of its supporting microsomal membrane”. Alterations to the activity of membrane-bound enzymes by alterations to membrane fluidity are well known, but only as experimental manipulations. We consider that in the case of HMGR this represents the actual method of physiological control." @default.
• W2032789281 created "2016-06-24" @default.
• W2032789281 creator A5078988277 @default.
• W2032789281 creator A5090443202 @default.
• W2032789281 date "1976-06-01" @default.
• W2032789281 modified "2023-09-23" @default.
• W2032789281 title "The intracellular mechanism responsible for dietary feedback control of cholesterol synthesis" @default.
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• W2032789281 doi "https://doi.org/10.1016/0024-3205(76)90191-0" @default.
• W2032789281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/778523" @default.
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