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- W2032794920 abstract "Cytochrome P450 (CYP) inhibition studies are often performed on new chemical entities during the drug discovery stage. However, advances in combinatorial chemistry mean that an unprecedented number of compounds now require such evaluation. Recently, a microtiter plate assay that utilizes individually expressed CYP enzymes (Supersomes™) has been developed to facilitate this process. The authors discuss some of their experiences with this technology and its potential impact for higher throughput CYP2D6 enzyme inhibition studies." @default.
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- W2032794920 date "1998-10-01" @default.
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- W2032794920 title "Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies" @default.
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- W2032794920 doi "https://doi.org/10.1016/s1359-6446(98)01248-3" @default.
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