FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032800928> ?p ?o ?g. }

• W2032800928 endingPage "3308" @default.
• W2032800928 startingPage "3302" @default.
• W2032800928 abstract "1. In this study we investigated the role of catalase in relaxation induced by hydroxylamine, sodium azide, glyceryl trinitrate and hydrogen peroxide in isolated rings of rat aorta. 2. Hydrogen peroxide (1 microM-1 mM)-induced concentration-dependent relaxation of phenylephrine (PE)-induced tone in endothelium-containing rings. In endothelium-denuded rings, however, higher concentrations (30 microM-1 mM) of hydrogen peroxide were required to produce relaxation. The endothelium-dependent component of hydrogen peroxide-induced relaxation was abolished following pretreatment with N(O)-nitro-L-arginine methyl ester (L-NAME, 30 microM). L-NAME (30 microM) had no effect, however, on hydrogen peroxide-induced relaxation in endothelium-denuded rings. 3. Pretreatment of endothelium-denuded rings with catalase (1000 u ml-1) blocked relaxation induced by hydrogen peroxide (10 microM-1 mM). The ability of catalase to inhibit hydrogen peroxide-induced relaxation was partially blocked following incubation with 3-amino-1,2, 4-triazole (AT, 50 mM) for 30 min and completely blocked at 90 min. 4. Pretreatment of endothelium-denuded rings with methylene blue (MeB, 30 microM) inhibited relaxation induced by hydrogen peroxide (10 microM-1 mM), sodium azide (1-300 nM), hydroxylamine (1-300 nM) and glyceryl trinitrate (1-100 nM) suggesting that each acted by stimulation of soluble guanylate cyclase. 5. Pretreatment of endothelium-denuded rings with AT (1-50 mM, 90 min) to inhibit endogenous catalase blocked relaxation induced by sodium azide (1-300 nM) and hydroxylamine (1-300 nM) but had no effect on relaxation induced by hydrogen peroxide (10 microM-1 mM) or glyceryl trinitrate (1-100 nM). 6. In a cell-free system, incubation of sodium azide (10 microM-3 mM) and hydroxylamine (10 microM-30 mM) but not glyceryl trinitrate (10 microM-1 mM) with catalase (1000 u ml-1) in the presence of hydrogen peroxide (1 mM) led to production of nitrite, a major breakdown product of nitric oxide. AT (1-100 mM) inhibited, in a concentration-dependent manner, the formation of nitrite from azide in the presence of hydrogen peroxide. 7. These data suggest that metabolism by catalase plays an important role in the relaxation induced by hydroxylamine and sodium azide in isolated rings of rat aorta. Relaxation appears to be due to formation of nitric oxide and activation of soluble guanylate cyclase. In contrast, metabolism by catalase does not appear to be involved in the relaxant actions of hydrogen peroxide or glyceryl trinitrate." @default.
• W2032800928 created "2016-06-24" @default.
• W2032800928 creator A5037719165 @default.
• W2032800928 creator A5084707286 @default.
• W2032800928 date "1995-12-01" @default.
• W2032800928 modified "2023-10-14" @default.
• W2032800928 title "The inhibitory effect of 3‐amino‐1,2,4‐triazole on relaxation induced by hydroxylamine and sodium azide but not hydrogen peroxide or glyceryl trinitrate in rat aorta" @default.
• W2032800928 cites W1499834471 @default.
• W2032800928 cites W1584138159 @default.
• W2032800928 cites W176913255 @default.
• W2032800928 cites W1900029203 @default.
• W2032800928 cites W1971090056 @default.
• W2032800928 cites W1979888161 @default.
• W2032800928 cites W1981922463 @default.
• W2032800928 cites W1986655462 @default.
• W2032800928 cites W1988175750 @default.
• W2032800928 cites W1990802251 @default.
• W2032800928 cites W1995862463 @default.
• W2032800928 cites W2000075945 @default.
• W2032800928 cites W2007689001 @default.
• W2032800928 cites W2022807258 @default.
• W2032800928 cites W2050051828 @default.
• W2032800928 cites W2065190476 @default.
• W2032800928 cites W2071607261 @default.
• W2032800928 cites W2092459487 @default.
• W2032800928 cites W2150296948 @default.
• W2032800928 cites W2243404144 @default.
• W2032800928 cites W2255298136 @default.
• W2032800928 cites W2260835883 @default.
• W2032800928 cites W2337788275 @default.
• W2032800928 cites W2404672763 @default.
• W2032800928 cites W2409404906 @default.
• W2032800928 cites W2411482116 @default.
• W2032800928 cites W2418066417 @default.
• W2032800928 cites W2418766239 @default.
• W2032800928 cites W34237247 @default.
• W2032800928 cites W35681168 @default.
• W2032800928 cites W43833714 @default.
• W2032800928 cites W46996808 @default.
• W2032800928 doi "https://doi.org/10.1111/j.1476-5381.1995.tb15139.x" @default.
• W2032800928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909194" @default.
• W2032800928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8719811" @default.
• W2032800928 hasPublicationYear "1995" @default.
• W2032800928 type Work @default.
• W2032800928 sameAs 2032800928 @default.
• W2032800928 citedByCount "40" @default.
• W2032800928 countsByYear W20328009282012 @default.
• W2032800928 countsByYear W20328009282013 @default.
• W2032800928 countsByYear W20328009282017 @default.
• W2032800928 countsByYear W20328009282018 @default.
• W2032800928 crossrefType "journal-article" @default.
• W2032800928 hasAuthorship W2032800928A5037719165 @default.
• W2032800928 hasAuthorship W2032800928A5084707286 @default.
• W2032800928 hasBestOaLocation W20328009281 @default.
• W2032800928 hasConcept C13965031 @default.
• W2032800928 hasConcept C178790620 @default.
• W2032800928 hasConcept C185592680 @default.
• W2032800928 hasConcept C2775999725 @default.
• W2032800928 hasConcept C2778004101 @default.
• W2032800928 hasConcept C2778979269 @default.
• W2032800928 hasConcept C2781417787 @default.
• W2032800928 hasConcept C519581460 @default.
• W2032800928 hasConcept C533411734 @default.
• W2032800928 hasConcept C55493867 @default.
• W2032800928 hasConcept C71240020 @default.
• W2032800928 hasConceptScore W2032800928C13965031 @default.
• W2032800928 hasConceptScore W2032800928C178790620 @default.
• W2032800928 hasConceptScore W2032800928C185592680 @default.
• W2032800928 hasConceptScore W2032800928C2775999725 @default.
• W2032800928 hasConceptScore W2032800928C2778004101 @default.
• W2032800928 hasConceptScore W2032800928C2778979269 @default.
• W2032800928 hasConceptScore W2032800928C2781417787 @default.
• W2032800928 hasConceptScore W2032800928C519581460 @default.
• W2032800928 hasConceptScore W2032800928C533411734 @default.
• W2032800928 hasConceptScore W2032800928C55493867 @default.
• W2032800928 hasConceptScore W2032800928C71240020 @default.
• W2032800928 hasIssue "8" @default.
• W2032800928 hasLocation W20328009281 @default.
• W2032800928 hasLocation W20328009282 @default.
• W2032800928 hasLocation W20328009283 @default.
• W2032800928 hasLocation W20328009284 @default.
• W2032800928 hasOpenAccess W2032800928 @default.
• W2032800928 hasPrimaryLocation W20328009281 @default.
• W2032800928 hasRelatedWork W2016696944 @default.
• W2032800928 hasRelatedWork W2053538842 @default.
• W2032800928 hasRelatedWork W2078660790 @default.
• W2032800928 hasRelatedWork W2116012372 @default.
• W2032800928 hasRelatedWork W2159780227 @default.
• W2032800928 hasRelatedWork W2378240399 @default.
• W2032800928 hasRelatedWork W2411213137 @default.
• W2032800928 hasRelatedWork W4210583805 @default.
• W2032800928 hasRelatedWork W4306407686 @default.
• W2032800928 hasRelatedWork W964043021 @default.
• W2032800928 hasVolume "116" @default.
• W2032800928 isParatext "false" @default.
• W2032800928 isRetracted "false" @default.
• W2032800928 magId "2032800928" @default.
• W2032800928 workType "article" @default.