Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032801447> ?p ?o ?g. }
- W2032801447 endingPage "415" @default.
- W2032801447 startingPage "409" @default.
- W2032801447 abstract "Approximately 40-70% of treatment-resistant schizophrenic patients fail to benefit from clozapine monotherapy or are partial responders. During the last years several clozapine adjunctive agents have come into clinical practice. This study aims to critically review all published randomized, double-blind, placebo-controlled clinical trials (RCTs) regarding the efficacy and safety of adjunctive agents in clozapine-resistant schizophrenic or schizoaffective patients. A MEDLINE search for RCTs on clozapine adjunctive agents published from January 1980 to February 2004 was conducted. All identified papers were critically reviewed and examined against several methodological features as well as clinical and pharmacological parameters. Eleven trials including 270 patients, partial or non-responders to clozapine, assessed the efficacy of sulpiride, lithium, lamotrigine, fluoxetine, glycine, d-serine, d-cycloserine and ethyl-eicosapentanoate (E-EPA) as clozapine adjuncts. There were eight parallel-group and three crossover trials. The inclusion criteria varied widely. The duration as well as the dosage of clozapine monotherapy were reported adequate in only one trial. Plasma clozapine levels were assessed in only three trials. Main side-effects reported were hypersalivation, sedation, diarrhea, nausea, hyperprolactinaemia. The outcome favored clozapine augmentation with sulpiride, lamotrigine and E-EPA. Lithium was shown to benefit only schizoaffective patients. However, the methodological shortcomings of trials analyzed limit the impact of evidence provided." @default.
- W2032801447 created "2016-06-24" @default.
- W2032801447 creator A5016846911 @default.
- W2032801447 creator A5044413460 @default.
- W2032801447 creator A5087472890 @default.
- W2032801447 creator A5024639606 @default.
- W2032801447 date "2005-08-01" @default.
- W2032801447 modified "2023-09-26" @default.
- W2032801447 title "Randomized controlled augmentation trials in clozapine-resistant schizophrenic patients: a critical review" @default.
- W2032801447 cites W131681483 @default.
- W2032801447 cites W14678275 @default.
- W2032801447 cites W1957187487 @default.
- W2032801447 cites W1970908493 @default.
- W2032801447 cites W1975464025 @default.
- W2032801447 cites W1979594821 @default.
- W2032801447 cites W1985731915 @default.
- W2032801447 cites W1988245592 @default.
- W2032801447 cites W2010663446 @default.
- W2032801447 cites W2021087332 @default.
- W2032801447 cites W2022180773 @default.
- W2032801447 cites W2034101137 @default.
- W2032801447 cites W2037491528 @default.
- W2032801447 cites W2038806808 @default.
- W2032801447 cites W2044222389 @default.
- W2032801447 cites W2056692846 @default.
- W2032801447 cites W2057274111 @default.
- W2032801447 cites W2067786055 @default.
- W2032801447 cites W2068854599 @default.
- W2032801447 cites W2072365144 @default.
- W2032801447 cites W2077169327 @default.
- W2032801447 cites W2078790185 @default.
- W2032801447 cites W2081824154 @default.
- W2032801447 cites W2085360366 @default.
- W2032801447 cites W2095581597 @default.
- W2032801447 cites W2102023134 @default.
- W2032801447 cites W2111410851 @default.
- W2032801447 cites W2121458109 @default.
- W2032801447 cites W2130211592 @default.
- W2032801447 cites W2130279922 @default.
- W2032801447 cites W2131417790 @default.
- W2032801447 cites W2140726784 @default.
- W2032801447 cites W2166158209 @default.
- W2032801447 cites W2273674479 @default.
- W2032801447 cites W2329708303 @default.
- W2032801447 cites W2607257274 @default.
- W2032801447 cites W4230685253 @default.
- W2032801447 cites W59918674 @default.
- W2032801447 cites W940697911 @default.
- W2032801447 doi "https://doi.org/10.1016/j.eurpsy.2004.12.007" @default.
- W2032801447 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16171655" @default.
- W2032801447 hasPublicationYear "2005" @default.
- W2032801447 type Work @default.
- W2032801447 sameAs 2032801447 @default.
- W2032801447 citedByCount "55" @default.
- W2032801447 countsByYear W20328014472012 @default.
- W2032801447 countsByYear W20328014472013 @default.
- W2032801447 countsByYear W20328014472014 @default.
- W2032801447 countsByYear W20328014472015 @default.
- W2032801447 countsByYear W20328014472017 @default.
- W2032801447 countsByYear W20328014472018 @default.
- W2032801447 countsByYear W20328014472019 @default.
- W2032801447 countsByYear W20328014472020 @default.
- W2032801447 countsByYear W20328014472021 @default.
- W2032801447 crossrefType "journal-article" @default.
- W2032801447 hasAuthorship W2032801447A5016846911 @default.
- W2032801447 hasAuthorship W2032801447A5024639606 @default.
- W2032801447 hasAuthorship W2032801447A5044413460 @default.
- W2032801447 hasAuthorship W2032801447A5087472890 @default.
- W2032801447 hasConcept C118552586 @default.
- W2032801447 hasConcept C126322002 @default.
- W2032801447 hasConcept C15744967 @default.
- W2032801447 hasConcept C168563851 @default.
- W2032801447 hasConcept C2776412080 @default.
- W2032801447 hasConcept C2778186239 @default.
- W2032801447 hasConcept C2778802184 @default.
- W2032801447 hasConcept C2779727114 @default.
- W2032801447 hasConcept C2779998641 @default.
- W2032801447 hasConcept C2780325297 @default.
- W2032801447 hasConcept C2780864610 @default.
- W2032801447 hasConcept C42219234 @default.
- W2032801447 hasConcept C71924100 @default.
- W2032801447 hasConceptScore W2032801447C118552586 @default.
- W2032801447 hasConceptScore W2032801447C126322002 @default.
- W2032801447 hasConceptScore W2032801447C15744967 @default.
- W2032801447 hasConceptScore W2032801447C168563851 @default.
- W2032801447 hasConceptScore W2032801447C2776412080 @default.
- W2032801447 hasConceptScore W2032801447C2778186239 @default.
- W2032801447 hasConceptScore W2032801447C2778802184 @default.
- W2032801447 hasConceptScore W2032801447C2779727114 @default.
- W2032801447 hasConceptScore W2032801447C2779998641 @default.
- W2032801447 hasConceptScore W2032801447C2780325297 @default.
- W2032801447 hasConceptScore W2032801447C2780864610 @default.
- W2032801447 hasConceptScore W2032801447C42219234 @default.
- W2032801447 hasConceptScore W2032801447C71924100 @default.
- W2032801447 hasIssue "5-6" @default.
- W2032801447 hasLocation W20328014471 @default.
- W2032801447 hasLocation W20328014472 @default.
- W2032801447 hasOpenAccess W2032801447 @default.