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- W2032801740 abstract "Mouse EL4 lymphoma cells have been selected in vitro for resistance to methotrexate. Four independently derived resistant cell lines are described. Each has amplified dihydrofolate reductase (DHFR) genes, and overproduces DHFR RNA and DHFR protein. In three of the four cell lines DNA rearrangement has occurred near the ends of the DHFR gene. The rearrangement is different in each case, but always involves only a proportion of the DHFR genes." @default.
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- W2032801740 date "1970-03-01" @default.
- W2032801740 modified "2023-09-23" @default.
- W2032801740 title "Amethopterin-induced changes in the multiple forms of dihydrofolate reductase from L1210 cells" @default.
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- W2032801740 doi "https://doi.org/10.1016/0003-9861(70)90440-6" @default.
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