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• W2032807908 abstract "Los fármacos inhibidores del factor de necrosis tumoral alfa se usan cada vez más frecuentemente en la práctica clínica diaria. Han mostrado su efectividad en el tratamiento de trastornos de base inflamatoria mediada por el sistema inmunitario, principalmente enfermedades reumáticas, pero también en la enfermedad inflamatoria intestinal y en la psoriasis. En los últimos años se han descrito diversos efectos secundarios, entre los cuales se encuentra el desarrollo, que resulta paradójico, de psoriasis o exantemas psoriasiformes. Desde finales de los noventa, la extensión de estos fármacos a la edad pediátrica es un hecho, y es necesario que los pediatras conozcamos los fenómenos adversos que pueden producir. Describimos aquí un caso de psoriasis invertida secundaria al tratamiento con infliximab y adalimumab en un paciente de 13 años con enfermedad de Crohn. Hasta donde llegamos a conocer, se trata del primer caso comunicado en edad pediátrica, así como el primer caso desencadenado por adalimumab en la enfermedad inflamatoria intestinal. Anti-TNF drugs are used increasingly in several diseases with immune-mediated inflammation, not only in rheumatological conditions, but also in inflammatory bowel disease and psoriasis. Different side effects have been described over the last few years, including the development of psoriasis or psoriasiform exanthemas. These drugs began to be used in paediatrics during the 90's, therefore paediatricians need to be aware of the adverse effects that may occur. We describe here a flexural psoriasis induced by both infliximab and adalimumab in a paediatric patient with Crohn's Disease. To the best of our knowledge, this is the first reported paediatric case of psoriasis triggered by an anti-TNF drug, as well as the first case of psoriasis induced by adalimumab in patients with inflammatory bowel disease." @default.
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• W2032807908 date "2009-03-01" @default.
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• W2032807908 title "Psoriasis secundaria al tratamiento con infliximab y adalimumab en la enfermedad de Crohn" @default.
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• W2032807908 doi "https://doi.org/10.1016/j.anpedi.2008.11.013" @default.
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