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• W2032808049 abstract "BACKGROUND:The role of matrix metalloproteinase 9 (MMP-9) polymorphisms in breast cancer risk remains unclear. The purpose of this study was to evaluate the association between MMP-9 variants and breast cancer susceptibility. MATERIAL AND METHODS:Case-control studies were searched on electronic databases to retrieve related articles published between 2000 and 2014 concerning the role of MMP-9 variants in breast cancer risk. Pooled odds ratios (OR) with correlative 95% confidence intervals (CI) were employed to assess this association. RESULTS:Ten articles were screened out, including 6177 breast cancer patients and 6726 matched-controls. For rs3918242 (-1562 C/T), 6 studies contained 1435 patients and 1446 controls. Although the frequency of risk allele C was higher in breast cancer patients than in controls, only TT genotype in recessive model was significantly associated with increased risk of breast cancer (TT vs. CT+CC: OR=1.55, 95% CI=1.12–2.16, P=0.009) in a fixed-effects model. This significant relationship was not observed in other genetic models (P>0.05). No significant association was found between breast cancer risk and rs17576, rs2250889, and rs3787268 under any genetic models. CONCLUSIONS:Our results show that TT genotype of MMP-9–1562 C/T polymorphism might be a risk factor for breast cancer. More studies are needed to further explore this association." @default.
• W2032808049 created "2016-06-24" @default.
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• W2032808049 date "2015-01-01" @default.
• W2032808049 modified "2023-09-29" @default.
• W2032808049 title "Association between Four MMP-9 Polymorphisms and Breast Cancer Risk: A Meta-Analysis" @default.
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• W2032808049 doi "https://doi.org/10.12659/msm.893890" @default.
• W2032808049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4413812" @default.
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