FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032809711> ?p ?o ?g. }

• W2032809711 endingPage "31" @default.
• W2032809711 startingPage "21" @default.
• W2032809711 abstract "The role of phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine (PE) methylation pathway in the secretion of very low density lipoproteins (VLDL) by cultured rat hepatocytes has been investigated by determining the effects of inhibitors. We have shown that bezafibrate and clofibric acid, known hypolipidemic agents, are potent inhibitors of PE methylation (see accompanying paper by Nishimaki-Mogami et al. (1996) Biochim. Biophys. Acta 1304). In hepatocytes incubated with ethanolamine, which maintained cellular PE levels and PE methylation activity, bezafibrate (200 microM) decreased the secretion of triacylglycerol (TG), PC, apolipoproteins B48, and E in VLDL by 50-75%. In contrast, bezafibrate at this concentration had marginal effect on VLDL secretion (83-115% of control) by hepatocytes that had been cultured in the absence of ethanolamine. In these cells PE levels and PE methylation activity had decreased by approx. 40%. VLDL secretion was decreased at concentrations similar to those required to inhibit PE methylation, and was accompanied by an increase in cellular TG levels. The same ethanolamine-dependent effects were produced by clofibric acid and also by 3-deazaadenosine (DZA), an inhibitor of cellular methylation reactions. These results indicate that PC synthesis via the PE methylation pathway plays a significant role in VLDL secretion in rat hepatocytes if the pathway is maintained at levels comparable to those in vivo. The reductions of PE methylation by bezafibrate and DZA did not affect the total amount of apolipoprotein B48 secreted into the medium. The decrease in apolipoprotein B48 in VLDL caused by bezafibrate was accompanied by an increase in apolipoprotein B48 in the HDL density range. In contrast, the amount of apolipoprotein B100 in VLDL and density determined by sequential flotation were unaffected. These findings indicate that rapid reduction of PC synthesis via PE methylation does not affect the secretion of apolipoprotein B48- or B100-containing lipoprotein particles, but does impair the lipidation of particles containing apolipoprotein B48, but not apolipoprotein B100." @default.
• W2032809711 created "2016-06-24" @default.
• W2032809711 creator A5030878699 @default.
• W2032809711 creator A5069671627 @default.
• W2032809711 creator A5085420437 @default.
• W2032809711 date "1996-11-01" @default.
• W2032809711 modified "2023-09-26" @default.
• W2032809711 title "The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins" @default.
• W2032809711 cites W11746928 @default.
• W2032809711 cites W1487589123 @default.
• W2032809711 cites W1498346306 @default.
• W2032809711 cites W1499889283 @default.
• W2032809711 cites W1500516478 @default.
• W2032809711 cites W1504110485 @default.
• W2032809711 cites W1505996156 @default.
• W2032809711 cites W1516164364 @default.
• W2032809711 cites W1536065758 @default.
• W2032809711 cites W1541084827 @default.
• W2032809711 cites W1551374056 @default.
• W2032809711 cites W1554617882 @default.
• W2032809711 cites W1557907146 @default.
• W2032809711 cites W1579835576 @default.
• W2032809711 cites W1586986973 @default.
• W2032809711 cites W1599366995 @default.
• W2032809711 cites W1604863183 @default.
• W2032809711 cites W1606919098 @default.
• W2032809711 cites W1626408496 @default.
• W2032809711 cites W1775749144 @default.
• W2032809711 cites W1898264975 @default.
• W2032809711 cites W1909628212 @default.
• W2032809711 cites W1921601722 @default.
• W2032809711 cites W1943281726 @default.
• W2032809711 cites W1964375961 @default.
• W2032809711 cites W1967326101 @default.
• W2032809711 cites W1974731001 @default.
• W2032809711 cites W1975282196 @default.
• W2032809711 cites W1987207967 @default.
• W2032809711 cites W1988317051 @default.
• W2032809711 cites W1991846031 @default.
• W2032809711 cites W2041395627 @default.
• W2032809711 cites W2051480798 @default.
• W2032809711 cites W2052008556 @default.
• W2032809711 cites W2062487777 @default.
• W2032809711 cites W2089747267 @default.
• W2032809711 cites W2108445985 @default.
• W2032809711 cites W2125790654 @default.
• W2032809711 cites W2142750016 @default.
• W2032809711 cites W2145343681 @default.
• W2032809711 cites W2145824100 @default.
• W2032809711 cites W2396535343 @default.
• W2032809711 doi "https://doi.org/10.1016/s0005-2760(96)00100-2" @default.
• W2032809711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8944747" @default.
• W2032809711 hasPublicationYear "1996" @default.
• W2032809711 type Work @default.
• W2032809711 sameAs 2032809711 @default.
• W2032809711 citedByCount "36" @default.
• W2032809711 countsByYear W20328097112015 @default.
• W2032809711 countsByYear W20328097112016 @default.
• W2032809711 countsByYear W20328097112017 @default.
• W2032809711 countsByYear W20328097112020 @default.
• W2032809711 crossrefType "journal-article" @default.
• W2032809711 hasAuthorship W2032809711A5030878699 @default.
• W2032809711 hasAuthorship W2032809711A5069671627 @default.
• W2032809711 hasAuthorship W2032809711A5085420437 @default.
• W2032809711 hasConcept C104317684 @default.
• W2032809711 hasConcept C126322002 @default.
• W2032809711 hasConcept C134018914 @default.
• W2032809711 hasConcept C181199279 @default.
• W2032809711 hasConcept C185592680 @default.
• W2032809711 hasConcept C202751555 @default.
• W2032809711 hasConcept C2776200302 @default.
• W2032809711 hasConcept C2776330855 @default.
• W2032809711 hasConcept C2776362216 @default.
• W2032809711 hasConcept C2778163477 @default.
• W2032809711 hasConcept C2778918659 @default.
• W2032809711 hasConcept C2779745421 @default.
• W2032809711 hasConcept C2780072125 @default.
• W2032809711 hasConcept C2780784506 @default.
• W2032809711 hasConcept C2781170229 @default.
• W2032809711 hasConcept C33288867 @default.
• W2032809711 hasConcept C41625074 @default.
• W2032809711 hasConcept C49039625 @default.
• W2032809711 hasConcept C55493867 @default.
• W2032809711 hasConcept C62746215 @default.
• W2032809711 hasConcept C71924100 @default.
• W2032809711 hasConcept C8243546 @default.
• W2032809711 hasConcept C86803240 @default.
• W2032809711 hasConceptScore W2032809711C104317684 @default.
• W2032809711 hasConceptScore W2032809711C126322002 @default.
• W2032809711 hasConceptScore W2032809711C134018914 @default.
• W2032809711 hasConceptScore W2032809711C181199279 @default.
• W2032809711 hasConceptScore W2032809711C185592680 @default.
• W2032809711 hasConceptScore W2032809711C202751555 @default.
• W2032809711 hasConceptScore W2032809711C2776200302 @default.
• W2032809711 hasConceptScore W2032809711C2776330855 @default.
• W2032809711 hasConceptScore W2032809711C2776362216 @default.
• W2032809711 hasConceptScore W2032809711C2778163477 @default.
• W2032809711 hasConceptScore W2032809711C2778918659 @default.

• next