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- W2032809798 abstract "Abstract Background To investigate the significance of Aurora B expression in hepatocellular carcinoma (HCC). Methods The Aurora B and Aurora A mRNA level was measured in 160 HCCs and the paired nontumorous liver tissues by reverse transcription-polymerase chain reaction. Mutations of the p53 and β-catenin genes were analyzed in 134 and 150 tumors, respectively, by direct sequencing of exon 2 to exon 11 of p53 and exon 3 of β-catenin . Anticancer effects of AZD1152-HQPA, an Aurora B kinase selective inhibitor, were examined in Huh-7 and Hep3B cell lines. Results Aurora B was overexpressed in 98 (61%) of 160 HCCs and in all 7 HCC cell lines examined. The overexpression of Aurora B was associated with Aurora A overexpression ( P = 0.0003) and p53 mutation ( P = 0.002) and was inversely associated with β - catenin mutation ( P = 0.002). Aurora B overexpression correlated with worse clinicopathologic characteristics. Multivariate analysis confirmed that Aurora B overexpression was an independent poor prognostic factor, despite its interaction with Aurora A overexpression and mutations of p53 and β - catenin . In Huh-7 and Hep3B cells, AZD1152-HQPA induced proliferation blockade, histone H3 (Ser10) dephosphorylation, cell cycle disturbance, and apoptosis. Conclusion Aurora B overexpression is an independent molecular marker predicting tumor invasiveness and poor prognosis of HCC. Aurora B kinase selective inhibitors are potential therapeutic agents for HCC treatment." @default.
- W2032809798 created "2016-06-24" @default.
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- W2032809798 date "2010-08-28" @default.
- W2032809798 modified "2023-10-18" @default.
- W2032809798 title "Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC" @default.
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- W2032809798 doi "https://doi.org/10.1186/1471-2407-10-461" @default.
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