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• W2032823103 abstract "The role of inflammation in inducing visceral hypersensitivity (VHS) in ulcerative colitis patients remains unknown. We tested the hypothesis that acute ulcerative colitis-like inflammation does not induce VHS. However, it sets up molecular conditions such that chronic stress following inflammation exaggerates single-unit afferent discharges to colorectal distension. We used dextran sodium sulfate (DSS) to induce ulcerative colitis-like inflammation and a 9-day heterotypic chronic stress protocol in rats. DSS upregulated Nav1.8 mRNA in colon-responsive dorsal root ganglion (DRG) neurons, TRPV1 in colonic muscularis externae (ME) and BDNF in spinal cord without affecting the spike frequency in spinal afferents or VMR to CRD. By contrast, chronic stress did not induce inflammation but it downregulated Kv1.1 and Kv1.4 mRNA in DRG neurons, and upregulated TRPA1 and nerve growth factor in ME, which mediated the increase of spike frequency and VMR to CRD. Chronic stress following inflammation exacerbated spike frequency in spinal afferent neurons. TRPA1 antagonist suppressed the sensitization of afferent neurons. DSS-inflammation did not affect the composition or excitation thresholds of low-threshold and high-threshold fibers. Chronic stress following inflammation increased the percent composition of high-threshold fibers and lowered the excitation threshold of both types of fibers. We conclude that not all types of inflammation induce VHS, whereas chronic stress induces VHS in the absence of inflammation." @default.
• W2032823103 created "2016-06-24" @default.
• W2032823103 creator A5005564617 @default.
• W2032823103 creator A5017533734 @default.
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• W2032823103 date "2013-09-01" @default.
• W2032823103 modified "2023-10-18" @default.
• W2032823103 title "Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats" @default.
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• W2032823103 doi "https://doi.org/10.1016/j.neuroscience.2013.06.024" @default.
• W2032823103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3864548" @default.
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