FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032828298> ?p ?o ?g. }

• W2032828298 endingPage "e46968" @default.
• W2032828298 startingPage "e46968" @default.
• W2032828298 abstract "Epidermal human keratinocytes are exposed to a wide range of environmental genotoxic insults, including the UV component of solar radiation. Epidermal homeostasis in response to cellular or tissue damage is maintained by a population of keratinocyte stem cells (KSC) that reside in the basal layer of the epithelium. Using cell sorting based on cell-surface markers, we have identified a novel α6 integrin(high+)/CD44(+) sub-population of basal keratinocytes. These α6 integrin(high+)/CD44(+) keratinocytes have both high proliferative potential, form colonies in culture that have characteristics of holoclones and have a unique pattern of resistance to apoptosis induced by UVB radiation or by agents that induce single- or double strand DNA breaks. Resistance to UVB induced apoptosis in the α6 integrin(high+)/CD44(+) cells involved increased expression of TAp63 and was overcome by PI-3 kinase inhibition. In marked contrast, the α6 integrin(high+)/CD44(+) cells were sensitive to apoptosis induced by the cross-linking agent cisplatin, and imatinib inhibition of c-Abl blocked the ability of cisplatin to kill α6 integrin(high+)/CD44(+) cells. Our findings reveal a population of basal keratinocytes with long-term proliferative properties that display specific patterns of apoptotic resistance that is dependent upon the genotoxic stimulus, and provide insights into how these cells can be targeted with chemotherapeutic agents." @default.
• W2032828298 created "2016-06-24" @default.
• W2032828298 creator A5045440350 @default.
• W2032828298 creator A5045463371 @default.
• W2032828298 creator A5047468298 @default.
• W2032828298 creator A5075997449 @default.
• W2032828298 date "2012-10-10" @default.
• W2032828298 modified "2023-10-03" @default.
• W2032828298 title "α6 Integrin and CD44 Enrich for a Primary Keratinocyte Population That Displays Resistance to UV-Induced Apoptosis" @default.
• W2032828298 cites W1522482495 @default.
• W2032828298 cites W1545112789 @default.
• W2032828298 cites W1548499384 @default.
• W2032828298 cites W1957564186 @default.
• W2032828298 cites W1969174629 @default.
• W2032828298 cites W1979580749 @default.
• W2032828298 cites W1992676863 @default.
• W2032828298 cites W2005356516 @default.
• W2032828298 cites W2012385670 @default.
• W2032828298 cites W2014938226 @default.
• W2032828298 cites W2019264784 @default.
• W2032828298 cites W2023427658 @default.
• W2032828298 cites W2029675195 @default.
• W2032828298 cites W2030752849 @default.
• W2032828298 cites W2036997692 @default.
• W2032828298 cites W2037977021 @default.
• W2032828298 cites W2053693231 @default.
• W2032828298 cites W2071638708 @default.
• W2032828298 cites W2077107241 @default.
• W2032828298 cites W2078130360 @default.
• W2032828298 cites W2081144106 @default.
• W2032828298 cites W2086828029 @default.
• W2032828298 cites W2138240309 @default.
• W2032828298 cites W2141375360 @default.
• W2032828298 cites W2153382986 @default.
• W2032828298 cites W2158699530 @default.
• W2032828298 cites W2167291962 @default.
• W2032828298 cites W2168211018 @default.
• W2032828298 cites W2416356367 @default.
• W2032828298 cites W2041244673 @default.
• W2032828298 doi "https://doi.org/10.1371/journal.pone.0046968" @default.
• W2032828298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3468583" @default.
• W2032828298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23071680" @default.
• W2032828298 hasPublicationYear "2012" @default.
• W2032828298 type Work @default.
• W2032828298 sameAs 2032828298 @default.
• W2032828298 citedByCount "9" @default.
• W2032828298 countsByYear W20328282982013 @default.
• W2032828298 countsByYear W20328282982015 @default.
• W2032828298 countsByYear W20328282982016 @default.
• W2032828298 countsByYear W20328282982018 @default.
• W2032828298 crossrefType "journal-article" @default.
• W2032828298 hasAuthorship W2032828298A5045440350 @default.
• W2032828298 hasAuthorship W2032828298A5045463371 @default.
• W2032828298 hasAuthorship W2032828298A5047468298 @default.
• W2032828298 hasAuthorship W2032828298A5075997449 @default.
• W2032828298 hasBestOaLocation W20328282981 @default.
• W2032828298 hasConcept C1491633281 @default.
• W2032828298 hasConcept C190283241 @default.
• W2032828298 hasConcept C195687474 @default.
• W2032828298 hasConcept C203014093 @default.
• W2032828298 hasConcept C2777074287 @default.
• W2032828298 hasConcept C2780932548 @default.
• W2032828298 hasConcept C28328180 @default.
• W2032828298 hasConcept C2908647359 @default.
• W2032828298 hasConcept C502942594 @default.
• W2032828298 hasConcept C54355233 @default.
• W2032828298 hasConcept C55493867 @default.
• W2032828298 hasConcept C71924100 @default.
• W2032828298 hasConcept C81885089 @default.
• W2032828298 hasConcept C86803240 @default.
• W2032828298 hasConcept C95444343 @default.
• W2032828298 hasConcept C99454951 @default.
• W2032828298 hasConceptScore W2032828298C1491633281 @default.
• W2032828298 hasConceptScore W2032828298C190283241 @default.
• W2032828298 hasConceptScore W2032828298C195687474 @default.
• W2032828298 hasConceptScore W2032828298C203014093 @default.
• W2032828298 hasConceptScore W2032828298C2777074287 @default.
• W2032828298 hasConceptScore W2032828298C2780932548 @default.
• W2032828298 hasConceptScore W2032828298C28328180 @default.
• W2032828298 hasConceptScore W2032828298C2908647359 @default.
• W2032828298 hasConceptScore W2032828298C502942594 @default.
• W2032828298 hasConceptScore W2032828298C54355233 @default.
• W2032828298 hasConceptScore W2032828298C55493867 @default.
• W2032828298 hasConceptScore W2032828298C71924100 @default.
• W2032828298 hasConceptScore W2032828298C81885089 @default.
• W2032828298 hasConceptScore W2032828298C86803240 @default.
• W2032828298 hasConceptScore W2032828298C95444343 @default.
• W2032828298 hasConceptScore W2032828298C99454951 @default.
• W2032828298 hasIssue "10" @default.
• W2032828298 hasLocation W20328282981 @default.
• W2032828298 hasLocation W20328282982 @default.
• W2032828298 hasLocation W20328282983 @default.
• W2032828298 hasLocation W20328282984 @default.
• W2032828298 hasLocation W20328282985 @default.
• W2032828298 hasOpenAccess W2032828298 @default.
• W2032828298 hasPrimaryLocation W20328282981 @default.
• W2032828298 hasRelatedWork W1518035471 @default.
• W2032828298 hasRelatedWork W1975343649 @default.

• next