FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032835746> ?p ?o ?g. }

• W2032835746 endingPage "557" @default.
• W2032835746 startingPage "550" @default.
• W2032835746 abstract "El complejo esclerosis tuberosa (CET) es uno de los trastornos neurocutáneos más frecuentes. Las tuberosidades corticales son las alteraciones patológicas más frecuentes y están relacionadas directamente con las principales expresiones clínicas, crisis epilépticas, retraso mental y comportamiento autista. El motivo de este trabajo es mostrar la importancia de los diferentes tipos de tuberosidades en la expresión clínica de los pacientes. La finalidad de este trabajo es relacionar el tamaño de las tuberosidades con la severidad de las alteraciones clínicas. Se estudiaron retrospectivamente los hallazgos clínicos y neurorradiológicos de 45 pacientes infantiles (22 mujeres y 23 varones) con CET y comparamos los hallazgos clínicos con la localización, el tamaño y el número de las tuberosidades corticales en cada paciente. Cuatro pacientes tenían tuberosidades muy voluminosas en los hemisferios cerebrales. Todas mostraban crisis epilépticas muy rebeldes y retraso mental profundo con comportamiento autista en 3 de ellos, pese a que se extirparon las tuberosidades en los 4 casos. Trece pacientes tenían tuberosidades de tamaño promedio-grande. Todos tenían crisis epilépticas muy rebeldes y retraso mental. Nueve pacientes habían tenido espasmos infantiles durante el primer año de vida y presentaban comportamiento autista. Veintiocho pacientes mostraban muchas tuberosidades de tamaño promedio-pequeño. La mayoría de ellos tenían crisis con buena respuesta al tratamiento farmacológico y poca prevalencia del autismo. Tres pacientes mostraban tuberosidad córtico-subcortical única en un polo frontal u occipital, todos ellos con crisis controladas con medicación y cociente intelectual normal. Trece pacientes de los 45 tenían tuberosidades cerebelosas, siempre asociadas a algún tipo de tuberosidad hemisférica y generalmente presentes en casos con mayor expresividad clínica. Las tuberosidades de gran tamaño, aunque sean poco numerosas, tienen mucha mayor relación con la presencia de sintomatología clínica severa —crisis epilépticas, retraso mental y comportamiento autista— que las tuberosidades de pequeño-mediano tamaño, aunque sean muy numerosas. Tuberous sclerosis complex (TSC) is one of the most frequent neurocutaneous disorders. Cortical tubers are the most common pathological changes in TSC and they are directly related to the disease's main clinical manifestations: seizures, mental retardation, and autistic behaviour. The aim of this study is to establish a correlation between tuber size and the severity of clinical features in TSC. We performed a retrospective study of the clinical and imaging findings from 45 TSC patients (22 females and 23 males) and compared the clinical features with the location, size, and number of the cortical tubers in each patient. Four patients had voluminous tubers located in 1 or both cerebral hemispheres. All of these patients had intractable seizures and severe mental retardation; 3 of these cases also presented with autistic behaviour, despite tubers having been resected in all 4 patients. Thirteen patients had tubers of large-to-average size, and all patients in this group showed intractable seizures and mental retardation. Nine patients who had experienced infantile spasms during the first year of life presented autistic behaviour. Multiple tubers of small to average size were found in 28 patients. In general, this group had seizures that responded well to antiepileptic drugs and a low prevalence of autism. In 3 patients who all presented good seizure control and normal intelligence, single cortical/subcortical tubers were located in the frontal or occipital lobes. Of the total of 45 patients, 13 had cerebellar as well as cerebral tubers; these were generally present in cases with more severe clinical features. Although large tubers are less common than small to medium-sized ones, they are much more likely to be accompanied by severe clinical symptoms (seizures, mental retardation and autistic behaviour), even when the smaller tubers are quite numerous." @default.
• W2032835746 created "2016-06-24" @default.
• W2032835746 creator A5008769534 @default.
• W2032835746 creator A5015863325 @default.
• W2032835746 creator A5039103734 @default.
• W2032835746 creator A5043204536 @default.
• W2032835746 creator A5043935423 @default.
• W2032835746 creator A5065573280 @default.
• W2032835746 creator A5081098343 @default.
• W2032835746 creator A5088222466 @default.
• W2032835746 date "2013-11-01" @default.
• W2032835746 modified "2023-09-27" @default.
• W2032835746 title "Importancia del tamaño de las tuberosidades en las complicaciones del complejo esclerosis tuberosa" @default.
• W2032835746 cites W1483729933 @default.
• W2032835746 cites W1528922898 @default.
• W2032835746 cites W1533031809 @default.
• W2032835746 cites W1537848456 @default.
• W2032835746 cites W1578183568 @default.
• W2032835746 cites W1585670565 @default.
• W2032835746 cites W1745175653 @default.
• W2032835746 cites W1854468459 @default.
• W2032835746 cites W1877075148 @default.
• W2032835746 cites W1969364577 @default.
• W2032835746 cites W1983869796 @default.
• W2032835746 cites W1988206127 @default.
• W2032835746 cites W1993581628 @default.
• W2032835746 cites W1996556344 @default.
• W2032835746 cites W2005625715 @default.
• W2032835746 cites W2016584618 @default.
• W2032835746 cites W2026430274 @default.
• W2032835746 cites W2035495486 @default.
• W2032835746 cites W2038933542 @default.
• W2032835746 cites W2041973479 @default.
• W2032835746 cites W2044709288 @default.
• W2032835746 cites W2049318603 @default.
• W2032835746 cites W2064822478 @default.
• W2032835746 cites W2066607750 @default.
• W2032835746 cites W2074133017 @default.
• W2032835746 cites W2076268719 @default.
• W2032835746 cites W2090050989 @default.
• W2032835746 cites W2090460203 @default.
• W2032835746 cites W2108199307 @default.
• W2032835746 cites W2109217841 @default.
• W2032835746 cites W2109955381 @default.
• W2032835746 cites W2110707589 @default.
• W2032835746 cites W2111616830 @default.
• W2032835746 cites W2127956748 @default.
• W2032835746 cites W2129526254 @default.
• W2032835746 cites W2157197322 @default.
• W2032835746 cites W2157915966 @default.
• W2032835746 cites W2165569288 @default.
• W2032835746 cites W2170671452 @default.
• W2032835746 cites W2222141033 @default.
• W2032835746 cites W2321478351 @default.
• W2032835746 cites W2383259826 @default.
• W2032835746 cites W2417801871 @default.
• W2032835746 doi "https://doi.org/10.1016/j.nrl.2012.11.002" @default.
• W2032835746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23274119" @default.
• W2032835746 hasPublicationYear "2013" @default.
• W2032835746 type Work @default.
• W2032835746 sameAs 2032835746 @default.
• W2032835746 citedByCount "13" @default.
• W2032835746 countsByYear W20328357462014 @default.
• W2032835746 countsByYear W20328357462016 @default.
• W2032835746 countsByYear W20328357462017 @default.
• W2032835746 countsByYear W20328357462018 @default.
• W2032835746 countsByYear W20328357462019 @default.
• W2032835746 countsByYear W20328357462020 @default.
• W2032835746 countsByYear W20328357462022 @default.
• W2032835746 crossrefType "journal-article" @default.
• W2032835746 hasAuthorship W2032835746A5008769534 @default.
• W2032835746 hasAuthorship W2032835746A5015863325 @default.
• W2032835746 hasAuthorship W2032835746A5039103734 @default.
• W2032835746 hasAuthorship W2032835746A5043204536 @default.
• W2032835746 hasAuthorship W2032835746A5043935423 @default.
• W2032835746 hasAuthorship W2032835746A5065573280 @default.
• W2032835746 hasAuthorship W2032835746A5081098343 @default.
• W2032835746 hasAuthorship W2032835746A5088222466 @default.
• W2032835746 hasBestOaLocation W20328357461 @default.
• W2032835746 hasConcept C138885662 @default.
• W2032835746 hasConcept C15708023 @default.
• W2032835746 hasConcept C71924100 @default.
• W2032835746 hasConceptScore W2032835746C138885662 @default.
• W2032835746 hasConceptScore W2032835746C15708023 @default.
• W2032835746 hasConceptScore W2032835746C71924100 @default.
• W2032835746 hasIssue "9" @default.
• W2032835746 hasLocation W20328357461 @default.
• W2032835746 hasLocation W20328357462 @default.
• W2032835746 hasOpenAccess W2032835746 @default.
• W2032835746 hasPrimaryLocation W20328357461 @default.
• W2032835746 hasRelatedWork W2609344916 @default.
• W2032835746 hasRelatedWork W2748952813 @default.
• W2032835746 hasRelatedWork W2780307509 @default.
• W2032835746 hasRelatedWork W2899084033 @default.
• W2032835746 hasRelatedWork W3031052312 @default.
• W2032835746 hasRelatedWork W3032375762 @default.
• W2032835746 hasRelatedWork W4210390885 @default.
• W2032835746 hasRelatedWork W59019880 @default.

• next