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- W2032837321 abstract "Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter." @default.
- W2032837321 created "2016-06-24" @default.
- W2032837321 creator A5051229546 @default.
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- W2032837321 date "2005-04-01" @default.
- W2032837321 modified "2023-10-11" @default.
- W2032837321 title "Src and Syk kinases: key regulators of phagocytic cell activation" @default.
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- W2032837321 doi "https://doi.org/10.1016/j.it.2005.02.002" @default.
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