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• W2032841542 abstract "In this work we assessed the suitability of two different lipid membranes for the simulation of a TolC protein from Salmonella enterica serovar Typhi. The TolC protein family is found in many pathogenic Gram-negative bacteria including Vibrio cholera and Pseudomonas aeruginosa and acts as an outer membrane channel for expulsion of drug and toxin from the cell. In S. typhi, the causative agent for typhoid fever, the TolC outer membrane protein is an antigen for the pathogen. The lipid environment is an important modulator of membrane protein structure and function. We evaluated the conformation of the TolC protein in the presence of DMPE and POPE bilayers using molecular dynamics simulation. The S. typhi TolC protein exhibited similar conformational dynamics to TolC and its homologues. Conformational flexibility of the protein is seen in the C-terminal, extracellular loops, and α-helical region. Despite differences in the two lipids, significant similarities in the motion of the protein in POPE and DMPE were observed, including the rotational motion of the C-terminal residues and the partially open extracellular loops. However, analysis of the trajectories demonstrated effects of hydrophobic matching of the TolC protein in the membrane, particularly in the lengthening of the lipids and subtle movements of the protein’s β-barrel towards the lower leaflet in DMPE. The study exhibited the use of molecular dynamics simulation in revealing the differential effect of membrane proteins and lipids on each other. In this study, POPE is potentially a more suitable model for future simulation of the S. typhi TolC protein." @default.
• W2032841542 created "2016-06-24" @default.
• W2032841542 creator A5016297663 @default.
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• W2032841542 creator A5082041539 @default.
• W2032841542 creator A5088060487 @default.
• W2032841542 creator A5088822744 @default.
• W2032841542 date "2014-07-11" @default.
• W2032841542 modified "2023-10-10" @default.
• W2032841542 title "Assembly and stability of Salmonella enterica ser. Typhi TolC protein in POPE and DMPE" @default.
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• W2032841542 doi "https://doi.org/10.1007/s10867-014-9357-9" @default.
• W2032841542 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4119184" @default.
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• W2032841542 hasPublicationYear "2014" @default.
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