FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032846178> ?p ?o ?g. }

• W2032846178 endingPage "590" @default.
• W2032846178 startingPage "575" @default.
• W2032846178 abstract "1. Current or voltage clamp recordings from CA3 neurones of the adult rat hippocampal slice were performed to study the inactivation properties of a slow outward K+ current identified as the delayed rectifier (IK). 2. In current clamp experiments, burst firing evoked from resting membrane potential by intracellular current injection was reduced or blocked by conditioning hyperpolarizing pre-pulses of 20-40 mV amplitude. This effect was inhibited by tetraethylammonium (TEA; 20 mM) but was unaffected by Cs+ (3 mM), 4-aminopyridine (4-AP; 2 mM), carbachol (30-50 microM), mast cell degranulating peptide (MCDP; 300 nM), thyrotrophin releasing hormone (TRH; 1 microM) or by a Ca(2+)-free solution containing Mn2+ or Co2+ (2 mM). 3. Single-electrode voltage clamp experiments were carried out on neurones superfused with Ca(2+)-free solution, containing tetrodotoxin (TTX; 1 microM), Mn2+ or Co2+ (2 mM), 4-AP (2 mM), Cs+ (3 mM) and carbachol (30 microM). Step depolarizations from a holding potential of -55 mV activated an outward current which reached a plateau after 200 ms, followed by an outward tail current. Such an outward current had the characteristics of IK. 4. The outward currents were significantly potentiated by conditioning hyperpolarizing pre-pulses suggesting the IK was reduced by a voltage-dependent inactivation process. Removal of inactivation was a function of the amplitude of the conditioning hyperpolarizing pre-pulse. At a holding potential of -55 mV removal of inactivation was time dependent with a time constant of 211 ms. High K+ (12.5 or 21.5 mM) solutions did not affect the inactivation characteristics of IK. 5. Tetraethylammonium (20 mM) or low concentrations of Ba2+ (0.1 mM) readily depressed the outward current without significantly affecting the inactivation process. Dendrotoxin (200 nM) also depressed such a slow current but, in addition, increased the inactivation process of IK. 6. It is suggested that removal of inactivation of IK by hyperpolarization can modulate cell excitability by fully restoring the ability of IK to inhibit burst firing of CA3 hippocampal neurones." @default.
• W2032846178 created "2016-06-24" @default.
• W2032846178 creator A5042838362 @default.
• W2032846178 creator A5054923894 @default.
• W2032846178 date "1992-11-01" @default.
• W2032846178 modified "2023-10-14" @default.
• W2032846178 title "Inactivation characteristics of a sustained, Ca(2+)-independent K+ current of rat hippocampal neurones in vitro." @default.
• W2032846178 cites W1570612396 @default.
• W2032846178 cites W1964926188 @default.
• W2032846178 cites W1966474984 @default.
• W2032846178 cites W1966603478 @default.
• W2032846178 cites W1976577382 @default.
• W2032846178 cites W1976763631 @default.
• W2032846178 cites W1990323937 @default.
• W2032846178 cites W1994288348 @default.
• W2032846178 cites W1996751302 @default.
• W2032846178 cites W1998072265 @default.
• W2032846178 cites W2002675422 @default.
• W2032846178 cites W2005291443 @default.
• W2032846178 cites W2008061474 @default.
• W2032846178 cites W2010012409 @default.
• W2032846178 cites W2013084711 @default.
• W2032846178 cites W2020599445 @default.
• W2032846178 cites W2025559018 @default.
• W2032846178 cites W2028454935 @default.
• W2032846178 cites W2031001660 @default.
• W2032846178 cites W2032553466 @default.
• W2032846178 cites W2037622734 @default.
• W2032846178 cites W2041629506 @default.
• W2032846178 cites W2044432956 @default.
• W2032846178 cites W2050773548 @default.
• W2032846178 cites W2059612988 @default.
• W2032846178 cites W2062963816 @default.
• W2032846178 cites W2071018633 @default.
• W2032846178 cites W2120745453 @default.
• W2032846178 cites W2156386700 @default.
• W2032846178 cites W2162011760 @default.
• W2032846178 cites W2288331821 @default.
• W2032846178 cites W2405131939 @default.
• W2032846178 doi "https://doi.org/10.1113/jphysiol.1992.sp019395" @default.
• W2032846178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1175748" @default.
• W2032846178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1338465" @default.
• W2032846178 hasPublicationYear "1992" @default.
• W2032846178 type Work @default.
• W2032846178 sameAs 2032846178 @default.
• W2032846178 citedByCount "12" @default.
• W2032846178 countsByYear W20328461782015 @default.
• W2032846178 countsByYear W20328461782017 @default.
• W2032846178 crossrefType "journal-article" @default.
• W2032846178 hasAuthorship W2032846178A5042838362 @default.
• W2032846178 hasAuthorship W2032846178A5054923894 @default.
• W2032846178 hasBestOaLocation W20328461782 @default.
• W2032846178 hasConcept C100837961 @default.
• W2032846178 hasConcept C12554922 @default.
• W2032846178 hasConcept C126322002 @default.
• W2032846178 hasConcept C134018914 @default.
• W2032846178 hasConcept C147944092 @default.
• W2032846178 hasConcept C170493617 @default.
• W2032846178 hasConcept C178790620 @default.
• W2032846178 hasConcept C181911157 @default.
• W2032846178 hasConcept C185263204 @default.
• W2032846178 hasConcept C185592680 @default.
• W2032846178 hasConcept C2776741303 @default.
• W2032846178 hasConcept C2777151030 @default.
• W2032846178 hasConcept C2778071365 @default.
• W2032846178 hasConcept C2778988552 @default.
• W2032846178 hasConcept C2780918503 @default.
• W2032846178 hasConcept C2780922449 @default.
• W2032846178 hasConcept C2781295685 @default.
• W2032846178 hasConcept C517785266 @default.
• W2032846178 hasConcept C55493867 @default.
• W2032846178 hasConcept C71924100 @default.
• W2032846178 hasConcept C83743174 @default.
• W2032846178 hasConcept C86803240 @default.
• W2032846178 hasConceptScore W2032846178C100837961 @default.
• W2032846178 hasConceptScore W2032846178C12554922 @default.
• W2032846178 hasConceptScore W2032846178C126322002 @default.
• W2032846178 hasConceptScore W2032846178C134018914 @default.
• W2032846178 hasConceptScore W2032846178C147944092 @default.
• W2032846178 hasConceptScore W2032846178C170493617 @default.
• W2032846178 hasConceptScore W2032846178C178790620 @default.
• W2032846178 hasConceptScore W2032846178C181911157 @default.
• W2032846178 hasConceptScore W2032846178C185263204 @default.
• W2032846178 hasConceptScore W2032846178C185592680 @default.
• W2032846178 hasConceptScore W2032846178C2776741303 @default.
• W2032846178 hasConceptScore W2032846178C2777151030 @default.
• W2032846178 hasConceptScore W2032846178C2778071365 @default.
• W2032846178 hasConceptScore W2032846178C2778988552 @default.
• W2032846178 hasConceptScore W2032846178C2780918503 @default.
• W2032846178 hasConceptScore W2032846178C2780922449 @default.
• W2032846178 hasConceptScore W2032846178C2781295685 @default.
• W2032846178 hasConceptScore W2032846178C517785266 @default.
• W2032846178 hasConceptScore W2032846178C55493867 @default.
• W2032846178 hasConceptScore W2032846178C71924100 @default.
• W2032846178 hasConceptScore W2032846178C83743174 @default.
• W2032846178 hasConceptScore W2032846178C86803240 @default.
• W2032846178 hasIssue "1" @default.
• W2032846178 hasLocation W20328461781 @default.

• next