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• W2032850312 abstract "► Examined the influence of age and fitness on ventilatory responses to hypercapnia and exercise in postmenopausal women. ► There was an inverse relationship between the HCVR gain and fitness, regardless of age. ► Age inversely affects Δ V ˙ E / Δ V ˙ CO 2 above the AT, regardless of fitness. ► This was due in part to age-related decreases in progesterone and FEV1. The extent to which aging affects respiratory control in postmenopausal women remains relatively unknown. In a cross-sectional study of 39 postmenopausal women (50–79 years), we examined the influence of age and fitness on the ventilatory responses to hypercapnia (HCVR; +8 mmHg) and exercise ( Δ V ˙ E / Δ V ˙ CO 2 ) above and below the anaerobic threshold (AT). Data were analyzed using the full cohort, by age (younger postmenopausal: YPM, 50–64 years; and older postmenopausal: OPM, 65–79 years) and fitness as per our previous work ( Active : V ˙ O 2 max ≥ 90% age-predicted values; and Sedentary : V ˙ O 2 max < 90% age-predicted values). Although age did not affect the sensitivity of HCVR, Active women had significantly lower HCVR gain compared to sedentary women ( Sedentary : 2.12 ± 0.80; Active : 1.57 ± 0.73, p = 0.02). In contrast, age, but not fitness, was inversely related to Δ V ˙ E / Δ V ˙ CO 2 above AT (YPM: 46.8 ± 11.5; OPM: 34.8 ± 6.9, p < 0.01) which may be explained, at least in part, by age-related declines in lung function. HCVR and Δ V ˙ E / Δ V ˙ CO 2 were not correlated." @default.
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• W2032850312 date "2012-10-01" @default.
• W2032850312 modified "2023-09-25" @default.
• W2032850312 title "Ventilatory responses to exercise and CO2 after menopause in healthy women: Effects of age and fitness" @default.
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• W2032850312 doi "https://doi.org/10.1016/j.resp.2012.06.020" @default.
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