FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032850918> ?p ?o ?g. }

• W2032850918 endingPage "1225" @default.
• W2032850918 startingPage "1219" @default.
• W2032850918 abstract "Recombinant human interleukin-1 (rhIL-1) can induce an elevation in calcium that has been ascribed exclusively to the stimulation of bone resorption. In the present study, we investigated whether rhIL-1 could also enhance the renal tubular reabsorption of calcium. The chronic influence of recombinant human rhIL-1 on renal calcium transport was investigated in thyroparathyroidectomized rats. Administration of rhIL-1 at the dose of 1.5 micrograms/day sc for 6 days induced a significant elevation in plasma calcium that was associated with a slight but significant decrease in the urinary excretion of calcium. Recording of the urinary calcium excretion expressed per ml glomerular filtrate at various plasma calcium levels, as achieved by acutely infusing calcium gluconate, indicates that rhIL-1 enhanced the tubular reabsorption of calcium. The calculated index of the tubular reabsorption of calcium (TRCal) was significantly increased by rhIL-1 (2.18 +/- 0.14 versus 1.79 +/- 0.07 mmol/l GFR, p < 0.05, in vehicle-treated rats). The change in the renal handling of calcium was not associated with stimulation of the tubular reabsorption of magnesium. Acute administration of a large dose (24 micrograms given in a bolus IV injection) of rhIL-1 enhanced within minutes the urinary excretion of prostaglandin E2. This effect was followed by a significant increase in urinary cAMP excretion and associated with a lower urinary calcium excretion. In conclusion, the results presented in this study indicate that rhIL-1 administered chronically selectively stimulated the tubular reabsorption of calcium. Experimental evidence suggests that this effect is mediated by prostaglandin-induced cAMP generation. These data strongly suggest that changes in the tubular handling of calcium could contribute to rhIL-1-induced hypercalcemia." @default.
• W2032850918 created "2016-06-24" @default.
• W2032850918 creator A5006557376 @default.
• W2032850918 creator A5019842380 @default.
• W2032850918 creator A5039655815 @default.
• W2032850918 creator A5054203364 @default.
• W2032850918 creator A5082866696 @default.
• W2032850918 date "2009-12-03" @default.
• W2032850918 modified "2023-10-10" @default.
• W2032850918 title "Stimulation by interleukin-1 of renal calcium reabsorption in thyroparathyroidectomized rats" @default.
• W2032850918 cites W1969481354 @default.
• W2032850918 cites W2012084509 @default.
• W2032850918 cites W2031504111 @default.
• W2032850918 cites W2037463093 @default.
• W2032850918 cites W2047888347 @default.
• W2032850918 cites W2053034249 @default.
• W2032850918 cites W2055335409 @default.
• W2032850918 cites W2057498103 @default.
• W2032850918 cites W2074092677 @default.
• W2032850918 cites W2078236994 @default.
• W2032850918 cites W2078369590 @default.
• W2032850918 cites W2095056719 @default.
• W2032850918 cites W2100484245 @default.
• W2032850918 cites W2103896404 @default.
• W2032850918 cites W2324525297 @default.
• W2032850918 doi "https://doi.org/10.1002/jbmr.5650081009" @default.
• W2032850918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8256659" @default.
• W2032850918 hasPublicationYear "2009" @default.
• W2032850918 type Work @default.
• W2032850918 sameAs 2032850918 @default.
• W2032850918 citedByCount "3" @default.
• W2032850918 countsByYear W20328509182017 @default.
• W2032850918 crossrefType "journal-article" @default.
• W2032850918 hasAuthorship W2032850918A5006557376 @default.
• W2032850918 hasAuthorship W2032850918A5019842380 @default.
• W2032850918 hasAuthorship W2032850918A5039655815 @default.
• W2032850918 hasAuthorship W2032850918A5054203364 @default.
• W2032850918 hasAuthorship W2032850918A5082866696 @default.
• W2032850918 hasConcept C10146269 @default.
• W2032850918 hasConcept C126322002 @default.
• W2032850918 hasConcept C134018914 @default.
• W2032850918 hasConcept C161457703 @default.
• W2032850918 hasConcept C185592680 @default.
• W2032850918 hasConcept C24998067 @default.
• W2032850918 hasConcept C2776697488 @default.
• W2032850918 hasConcept C2780091579 @default.
• W2032850918 hasConcept C519063684 @default.
• W2032850918 hasConcept C56906281 @default.
• W2032850918 hasConcept C71924100 @default.
• W2032850918 hasConcept C77411442 @default.
• W2032850918 hasConceptScore W2032850918C10146269 @default.
• W2032850918 hasConceptScore W2032850918C126322002 @default.
• W2032850918 hasConceptScore W2032850918C134018914 @default.
• W2032850918 hasConceptScore W2032850918C161457703 @default.
• W2032850918 hasConceptScore W2032850918C185592680 @default.
• W2032850918 hasConceptScore W2032850918C24998067 @default.
• W2032850918 hasConceptScore W2032850918C2776697488 @default.
• W2032850918 hasConceptScore W2032850918C2780091579 @default.
• W2032850918 hasConceptScore W2032850918C519063684 @default.
• W2032850918 hasConceptScore W2032850918C56906281 @default.
• W2032850918 hasConceptScore W2032850918C71924100 @default.
• W2032850918 hasConceptScore W2032850918C77411442 @default.
• W2032850918 hasIssue "10" @default.
• W2032850918 hasLocation W20328509181 @default.
• W2032850918 hasLocation W20328509182 @default.
• W2032850918 hasOpenAccess W2032850918 @default.
• W2032850918 hasPrimaryLocation W20328509181 @default.
• W2032850918 hasRelatedWork W1974087872 @default.
• W2032850918 hasRelatedWork W2007932581 @default.
• W2032850918 hasRelatedWork W2059373368 @default.
• W2032850918 hasRelatedWork W2061490845 @default.
• W2032850918 hasRelatedWork W2067692613 @default.
• W2032850918 hasRelatedWork W2086044276 @default.
• W2032850918 hasRelatedWork W2115067964 @default.
• W2032850918 hasRelatedWork W2327584050 @default.
• W2032850918 hasRelatedWork W2410559813 @default.
• W2032850918 hasRelatedWork W2412235378 @default.
• W2032850918 hasVolume "8" @default.
• W2032850918 isParatext "false" @default.
• W2032850918 isRetracted "false" @default.
• W2032850918 magId "2032850918" @default.
• W2032850918 workType "article" @default.