FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032854797> ?p ?o ?g. }

• W2032854797 endingPage "71" @default.
• W2032854797 startingPage "66" @default.
• W2032854797 abstract "Recently, we developed a novel automated, high throughput screening (HTS) methodology for the anaerobic intestinal parasite Entamoeba histolytica. We validated this HTS platform by screening a chemical library containing US Food and Drug Administration (FDA)-approved drugs and bioactive compounds. We identified an FDA-approved drug, auranofin, as most active against E. histolytica both in vitro and in vivo. Our cell culture and animal studies indicated that thioredoxin reductase, an enzyme involved in reactive oxygen species detoxification, was the target for auranofin in E. histolytica. Here, we discuss the rationale for drug development for three parasites which are major causes of diarrhea worldwide, E. histolytica, Giardia lamblia and Cryptosporidium parvum and extend our current finding of antiparasitic activity of auranofin to Entamoeba cysts, G. lamblia and C. parvum. These studies support the use of HTS assays and reprofiling FDA-approved drugs for new therapy for neglected tropical diseases." @default.
• W2032854797 created "2016-06-24" @default.
• W2032854797 creator A5029853082 @default.
• W2032854797 creator A5033544787 @default.
• W2032854797 creator A5040959574 @default.
• W2032854797 date "2013-01-01" @default.
• W2032854797 modified "2023-09-27" @default.
• W2032854797 title "Reprofiled drug targets ancient protozoans" @default.
• W2032854797 cites W1937283342 @default.
• W2032854797 cites W1965238609 @default.
• W2032854797 cites W1966597938 @default.
• W2032854797 cites W1966928239 @default.
• W2032854797 cites W1969682850 @default.
• W2032854797 cites W1972801090 @default.
• W2032854797 cites W1974260619 @default.
• W2032854797 cites W1978173290 @default.
• W2032854797 cites W1989421641 @default.
• W2032854797 cites W1994950778 @default.
• W2032854797 cites W1995879972 @default.
• W2032854797 cites W2021869123 @default.
• W2032854797 cites W2032067602 @default.
• W2032854797 cites W2033162668 @default.
• W2032854797 cites W2040156405 @default.
• W2032854797 cites W2052888691 @default.
• W2032854797 cites W2055907171 @default.
• W2032854797 cites W2074433251 @default.
• W2032854797 cites W2079433635 @default.
• W2032854797 cites W2082120087 @default.
• W2032854797 cites W2086715367 @default.
• W2032854797 cites W2090973686 @default.
• W2032854797 cites W2116106523 @default.
• W2032854797 cites W2123407823 @default.
• W2032854797 cites W2123845161 @default.
• W2032854797 cites W2132265655 @default.
• W2032854797 cites W2133153279 @default.
• W2032854797 cites W2135598891 @default.
• W2032854797 cites W2139360852 @default.
• W2032854797 cites W2140062125 @default.
• W2032854797 cites W2142108089 @default.
• W2032854797 cites W2149717051 @default.
• W2032854797 cites W2151462087 @default.
• W2032854797 cites W2152977880 @default.
• W2032854797 cites W2166979707 @default.
• W2032854797 cites W2332157689 @default.
• W2032854797 cites W4211257403 @default.
• W2032854797 cites W4231017639 @default.
• W2032854797 cites W4237038612 @default.
• W2032854797 doi "https://doi.org/10.4161/gmic.22596" @default.
• W2032854797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3555889" @default.
• W2032854797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23137963" @default.
• W2032854797 hasPublicationYear "2013" @default.
• W2032854797 type Work @default.
• W2032854797 sameAs 2032854797 @default.
• W2032854797 citedByCount "58" @default.
• W2032854797 countsByYear W20328547972013 @default.
• W2032854797 countsByYear W20328547972014 @default.
• W2032854797 countsByYear W20328547972015 @default.
• W2032854797 countsByYear W20328547972016 @default.
• W2032854797 countsByYear W20328547972017 @default.
• W2032854797 countsByYear W20328547972018 @default.
• W2032854797 countsByYear W20328547972019 @default.
• W2032854797 countsByYear W20328547972020 @default.
• W2032854797 countsByYear W20328547972021 @default.
• W2032854797 countsByYear W20328547972022 @default.
• W2032854797 countsByYear W20328547972023 @default.
• W2032854797 crossrefType "journal-article" @default.
• W2032854797 hasAuthorship W2032854797A5029853082 @default.
• W2032854797 hasAuthorship W2032854797A5033544787 @default.
• W2032854797 hasAuthorship W2032854797A5040959574 @default.
• W2032854797 hasBestOaLocation W20328547971 @default.
• W2032854797 hasConcept C103637391 @default.
• W2032854797 hasConcept C142724271 @default.
• W2032854797 hasConcept C181199279 @default.
• W2032854797 hasConcept C203014093 @default.
• W2032854797 hasConcept C2776243873 @default.
• W2032854797 hasConcept C2776867272 @default.
• W2032854797 hasConcept C2777276848 @default.
• W2032854797 hasConcept C2777575956 @default.
• W2032854797 hasConcept C2777737464 @default.
• W2032854797 hasConcept C2777795018 @default.
• W2032854797 hasConcept C2780035454 @default.
• W2032854797 hasConcept C2780626423 @default.
• W2032854797 hasConcept C2781421772 @default.
• W2032854797 hasConcept C2911037157 @default.
• W2032854797 hasConcept C3623737 @default.
• W2032854797 hasConcept C55493867 @default.
• W2032854797 hasConcept C71924100 @default.
• W2032854797 hasConcept C86803240 @default.
• W2032854797 hasConcept C89423630 @default.
• W2032854797 hasConcept C98274493 @default.
• W2032854797 hasConceptScore W2032854797C103637391 @default.
• W2032854797 hasConceptScore W2032854797C142724271 @default.
• W2032854797 hasConceptScore W2032854797C181199279 @default.
• W2032854797 hasConceptScore W2032854797C203014093 @default.
• W2032854797 hasConceptScore W2032854797C2776243873 @default.
• W2032854797 hasConceptScore W2032854797C2776867272 @default.
• W2032854797 hasConceptScore W2032854797C2777276848 @default.
• W2032854797 hasConceptScore W2032854797C2777575956 @default.

• next