Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032856345> ?p ?o ?g. }
- W2032856345 endingPage "432" @default.
- W2032856345 startingPage "424" @default.
- W2032856345 abstract "End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor organ shortage and the need for immunosuppression limit the impact of transplantation. The regeneration of whole organs could theoretically overcome these hurdles. Early milestones have been met by combining stem and progenitor cells with increasingly complex scaffold materials and culture conditions. Because the native extracellular matrix (ECM) guides organ development, repair and physiologic regeneration, it provides a promising alternative to synthetic scaffolds and a foundation for regenerative efforts. Perfusion decellularization is a novel technology that generates native ECM scaffolds with intact 3D anatomical architecture and vasculature. This review summarizes achievements to date and discusses the role of native ECM scaffolds in organ regeneration. End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor organ shortage and the need for immunosuppression limit the impact of transplantation. The regeneration of whole organs could theoretically overcome these hurdles. Early milestones have been met by combining stem and progenitor cells with increasingly complex scaffold materials and culture conditions. Because the native extracellular matrix (ECM) guides organ development, repair and physiologic regeneration, it provides a promising alternative to synthetic scaffolds and a foundation for regenerative efforts. Perfusion decellularization is a novel technology that generates native ECM scaffolds with intact 3D anatomical architecture and vasculature. This review summarizes achievements to date and discusses the role of native ECM scaffolds in organ regeneration." @default.
- W2032856345 created "2016-06-24" @default.
- W2032856345 creator A5049112383 @default.
- W2032856345 creator A5060525873 @default.
- W2032856345 date "2011-08-01" @default.
- W2032856345 modified "2023-10-18" @default.
- W2032856345 title "Organ engineering based on decellularized matrix scaffolds" @default.
- W2032856345 cites W1503134467 @default.
- W2032856345 cites W1515701811 @default.
- W2032856345 cites W1557258230 @default.
- W2032856345 cites W1946522955 @default.
- W2032856345 cites W1973876666 @default.
- W2032856345 cites W1976917834 @default.
- W2032856345 cites W1977885230 @default.
- W2032856345 cites W1978809285 @default.
- W2032856345 cites W1980780439 @default.
- W2032856345 cites W1987350026 @default.
- W2032856345 cites W1991386301 @default.
- W2032856345 cites W1992426307 @default.
- W2032856345 cites W1993692032 @default.
- W2032856345 cites W1994920661 @default.
- W2032856345 cites W1995373597 @default.
- W2032856345 cites W2001661294 @default.
- W2032856345 cites W2008565536 @default.
- W2032856345 cites W2011085226 @default.
- W2032856345 cites W2011590786 @default.
- W2032856345 cites W2018474760 @default.
- W2032856345 cites W2018599317 @default.
- W2032856345 cites W2019418878 @default.
- W2032856345 cites W2021822557 @default.
- W2032856345 cites W2022282748 @default.
- W2032856345 cites W2023385232 @default.
- W2032856345 cites W2027174548 @default.
- W2032856345 cites W2030902428 @default.
- W2032856345 cites W2031383502 @default.
- W2032856345 cites W203494167 @default.
- W2032856345 cites W2035259469 @default.
- W2032856345 cites W2035391762 @default.
- W2032856345 cites W2045218007 @default.
- W2032856345 cites W2045251955 @default.
- W2032856345 cites W2045859114 @default.
- W2032856345 cites W2049920231 @default.
- W2032856345 cites W2053162946 @default.
- W2032856345 cites W2054850711 @default.
- W2032856345 cites W2060700926 @default.
- W2032856345 cites W2067729477 @default.
- W2032856345 cites W2072712108 @default.
- W2032856345 cites W2077492833 @default.
- W2032856345 cites W2079769019 @default.
- W2032856345 cites W2081225884 @default.
- W2032856345 cites W2084974707 @default.
- W2032856345 cites W2085776993 @default.
- W2032856345 cites W2086057553 @default.
- W2032856345 cites W2087043975 @default.
- W2032856345 cites W2090223479 @default.
- W2032856345 cites W2090973560 @default.
- W2032856345 cites W2091498007 @default.
- W2032856345 cites W2095354371 @default.
- W2032856345 cites W2096237299 @default.
- W2032856345 cites W2099930446 @default.
- W2032856345 cites W2101228997 @default.
- W2032856345 cites W2102386843 @default.
- W2032856345 cites W2107291281 @default.
- W2032856345 cites W2110223227 @default.
- W2032856345 cites W2111338636 @default.
- W2032856345 cites W2113738161 @default.
- W2032856345 cites W2115142051 @default.
- W2032856345 cites W2116397695 @default.
- W2032856345 cites W2117681000 @default.
- W2032856345 cites W2118877693 @default.
- W2032856345 cites W2120949673 @default.
- W2032856345 cites W2128281971 @default.
- W2032856345 cites W2130201056 @default.
- W2032856345 cites W2136264977 @default.
- W2032856345 cites W2139320982 @default.
- W2032856345 cites W2145231066 @default.
- W2032856345 cites W2146677318 @default.
- W2032856345 cites W2161118621 @default.
- W2032856345 cites W2163442684 @default.
- W2032856345 cites W2167202160 @default.
- W2032856345 cites W2171313781 @default.
- W2032856345 cites W2328786770 @default.
- W2032856345 cites W2404442992 @default.
- W2032856345 cites W4211147424 @default.
- W2032856345 doi "https://doi.org/10.1016/j.molmed.2011.03.005" @default.
- W2032856345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21514224" @default.
- W2032856345 hasPublicationYear "2011" @default.
- W2032856345 type Work @default.
- W2032856345 sameAs 2032856345 @default.
- W2032856345 citedByCount "421" @default.
- W2032856345 countsByYear W20328563452012 @default.
- W2032856345 countsByYear W20328563452013 @default.
- W2032856345 countsByYear W20328563452014 @default.
- W2032856345 countsByYear W20328563452015 @default.
- W2032856345 countsByYear W20328563452016 @default.
- W2032856345 countsByYear W20328563452017 @default.
- W2032856345 countsByYear W20328563452018 @default.
- W2032856345 countsByYear W20328563452019 @default.