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- W2032866998 abstract "Sperm from all species studied thus far contain G-proteins. The presence of such signal-transducing proteins in these cells suggests that the regulation of sperm function might have control elements that are similar to ligand:receptor:G-protein:second messenger systems common to many somatic cells. This hypothesis is supported by experiments that demonstrate a potential intermediary role for the mouse sperm Gi-like protein in the acrosome reaction induced by ZP3. The specific function of this Gi-like protein in this important physiologic event is not known at this time, although possible roles in regulating ionic movements, cyclic nucleotide metabolism, and polyphosphoinositide turnover are possible candidates. Studies directed at the localization and biochemical identity of the mouse sperm Gi-like protein, as well as the nature of the second messenger system(s) modulated by this protein, are in progress and should help to delineate the sequence of events involved in some of the early steps of sperm-ZP interaction." @default.
- W2032866998 created "2016-06-24" @default.
- W2032866998 creator A5025662544 @default.
- W2032866998 date "1989-07-01" @default.
- W2032866998 modified "2023-09-23" @default.
- W2032866998 title "Mechanisms of Signal Transduction in Mouse Spermatozoa" @default.
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- W2032866998 doi "https://doi.org/10.1111/j.1749-6632.1989.tb25906.x" @default.
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