FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032870851> ?p ?o ?g. }

• W2032870851 endingPage "H1835" @default.
• W2032870851 startingPage "H1828" @default.
• W2032870851 abstract "Previous studies showed that the cardiac sympathetic afferent reflex (CSAR) is enhanced in dogs and rats with chronic heart failure (CHF) and that central ANG II type 1 receptors (AT 1 R) are involved in this augmented reflex. The aim of this study was to determine whether intracerebroventricular administration and microinjection of antisense oligodeoxynucleotides targeted to AT 1 R mRNA would attenuate the enhanced CSAR and decrease resting renal sympathetic nerve activity (RSNA) in rats with coronary ligation-induced CHF. The CSAR was elicited by application of bradykinin to the epicardial surface of the left ventricle. Reflex responses to epicardial administration of bradykinin were enhanced in rats with CHF. The response to bradykinin was determined every 50 min after intracerebroventricular administration (lateral ventricle) or microinjection (into paraventricular nucleus) of antisense or scrambled oligonucleotides to AT 1 R mRNA. AT 1 R mRNA and protein levels in the paraventricular nucleus were significantly reduced 5 h after administration of antisense. Antisense significantly decreased resting RSNA and normalized the enhanced CSAR responses to bradykinin in rats with CHF. Scrambled oligonucleotides did not alter resting RSNA or the enhanced responses to bradykinin in rats with CHF. No significant effects were found in sham-operated rats after administration of either antisense or scrambled oligonucleotides. These results strongly suggest that central AT 1 R mRNA antisense reduces expression of AT 1 R protein and normalizes the augmentation of this excitatory sympathetic reflex and that genetic manipulation of protein expression can be used to normalize the sympathetic enhancement in CHF." @default.
• W2032870851 created "2016-06-24" @default.
• W2032870851 creator A5030477066 @default.
• W2032870851 creator A5067301238 @default.
• W2032870851 creator A5070760299 @default.
• W2032870851 creator A5077503978 @default.
• W2032870851 creator A5085285424 @default.
• W2032870851 creator A5089415637 @default.
• W2032870851 date "2004-10-01" @default.
• W2032870851 modified "2023-10-14" @default.
• W2032870851 title "AT₁ receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure" @default.
• W2032870851 cites W131135619 @default.
• W2032870851 cites W1573813440 @default.
• W2032870851 cites W173932466 @default.
• W2032870851 cites W1963513992 @default.
• W2032870851 cites W1964816832 @default.
• W2032870851 cites W1972224752 @default.
• W2032870851 cites W1972311275 @default.
• W2032870851 cites W1975658214 @default.
• W2032870851 cites W1985606196 @default.
• W2032870851 cites W2005395398 @default.
• W2032870851 cites W2006432825 @default.
• W2032870851 cites W2017133647 @default.
• W2032870851 cites W2020128505 @default.
• W2032870851 cites W2038232427 @default.
• W2032870851 cites W2042571427 @default.
• W2032870851 cites W2047629394 @default.
• W2032870851 cites W2054634896 @default.
• W2032870851 cites W2057185378 @default.
• W2032870851 cites W2080217330 @default.
• W2032870851 cites W2102100685 @default.
• W2032870851 cites W2105540340 @default.
• W2032870851 cites W2113622686 @default.
• W2032870851 cites W2114752422 @default.
• W2032870851 cites W2128246009 @default.
• W2032870851 cites W2132307929 @default.
• W2032870851 cites W2135849925 @default.
• W2032870851 cites W2139831186 @default.
• W2032870851 cites W2140132727 @default.
• W2032870851 cites W2142538245 @default.
• W2032870851 cites W2159020714 @default.
• W2032870851 cites W2161850143 @default.
• W2032870851 cites W2162961198 @default.
• W2032870851 cites W2163685664 @default.
• W2032870851 cites W2188616440 @default.
• W2032870851 cites W2236271024 @default.
• W2032870851 cites W2252423519 @default.
• W2032870851 cites W2338638760 @default.
• W2032870851 cites W2340055496 @default.
• W2032870851 cites W2342716732 @default.
• W2032870851 doi "https://doi.org/10.1152/ajpheart.01245.2003" @default.
• W2032870851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15371269" @default.
• W2032870851 hasPublicationYear "2004" @default.
• W2032870851 type Work @default.
• W2032870851 sameAs 2032870851 @default.
• W2032870851 citedByCount "80" @default.
• W2032870851 countsByYear W20328708512012 @default.
• W2032870851 countsByYear W20328708512013 @default.
• W2032870851 countsByYear W20328708512014 @default.
• W2032870851 countsByYear W20328708512015 @default.
• W2032870851 countsByYear W20328708512016 @default.
• W2032870851 countsByYear W20328708512017 @default.
• W2032870851 countsByYear W20328708512018 @default.
• W2032870851 countsByYear W20328708512020 @default.
• W2032870851 countsByYear W20328708512023 @default.
• W2032870851 crossrefType "journal-article" @default.
• W2032870851 hasAuthorship W2032870851A5030477066 @default.
• W2032870851 hasAuthorship W2032870851A5067301238 @default.
• W2032870851 hasAuthorship W2032870851A5070760299 @default.
• W2032870851 hasAuthorship W2032870851A5077503978 @default.
• W2032870851 hasAuthorship W2032870851A5085285424 @default.
• W2032870851 hasAuthorship W2032870851A5089415637 @default.
• W2032870851 hasConcept C126322002 @default.
• W2032870851 hasConcept C134018914 @default.
• W2032870851 hasConcept C170493617 @default.
• W2032870851 hasConcept C2778198053 @default.
• W2032870851 hasConcept C2778921608 @default.
• W2032870851 hasConcept C2779591629 @default.
• W2032870851 hasConcept C62525196 @default.
• W2032870851 hasConcept C71924100 @default.
• W2032870851 hasConcept C83974742 @default.
• W2032870851 hasConceptScore W2032870851C126322002 @default.
• W2032870851 hasConceptScore W2032870851C134018914 @default.
• W2032870851 hasConceptScore W2032870851C170493617 @default.
• W2032870851 hasConceptScore W2032870851C2778198053 @default.
• W2032870851 hasConceptScore W2032870851C2778921608 @default.
• W2032870851 hasConceptScore W2032870851C2779591629 @default.
• W2032870851 hasConceptScore W2032870851C62525196 @default.
• W2032870851 hasConceptScore W2032870851C71924100 @default.
• W2032870851 hasConceptScore W2032870851C83974742 @default.
• W2032870851 hasIssue "4" @default.
• W2032870851 hasLocation W20328708511 @default.
• W2032870851 hasLocation W20328708512 @default.
• W2032870851 hasOpenAccess W2032870851 @default.
• W2032870851 hasPrimaryLocation W20328708511 @default.
• W2032870851 hasRelatedWork W2018368842 @default.
• W2032870851 hasRelatedWork W2033472167 @default.
• W2032870851 hasRelatedWork W2034583712 @default.

• next