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- W2032874889 abstract "Abstract The expression of chemokines and chemokine receptors was studied in Leishmania donovani (LD)‐infected human mononuclear phagocytes and the human monocytic cell line THP1. Our studies showed that LD infection caused the upregulation of three β chemokines (macrophage inflammatory protein‐1 alpha (MIP‐1α), MIP‐1β and RANTES (regulated on activation normal T cell expressed and secreted)), one α chemokine (interleukin‐8 (IL‐8)) and the CC chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis. The CCR5 upregulation in human mononuclear phagocytes and THP1 cells was also evident by confocal microscopy. The possible association of such upregulation in relation to Leishmania and human immunodeficiency virus (HIV) coinfection was discussed." @default.
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- W2032874889 date "2003-03-27" @default.
- W2032874889 modified "2023-10-15" @default.
- W2032874889 title "Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor" @default.
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- W2032874889 doi "https://doi.org/10.1046/j.1365-3083.2003.01227.x" @default.
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