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- W2032889770 abstract "1 Acute release of plasminogen activator (PA) was studied in rat isolated hindleg system perfused with Tyrode solution. 2 Leukotriene C4 (LTC4) and LTD4 dose-dependently induced the release of PA, which plateaued at 160 nmol l−1 and 200 nmol l−1, respectively. The amount of PA released was about 1 iu ml−1. The effects of LTC4 and LTD4 were not additive. 3 The PA released was identified as tissue-type PA (t-PA) by quenching experiments using anti-human t-PA IgG, by fibrin autography, and by the dependence of its activity on the presence of soluble fibrin. 4 LTE4 (300 and 450 nmol l−1) and 5-hydroxy-eicosatetraenoic acid (600 nmol l−1) did not induce any t-PA release in the perfusion system used. 5 Release of t-PA induced by LTC4 and LTD4 was inhibited by the leukotriene-receptor antagonist FPL 55712 (10 μmol l−1), whereas FPL 55712 did not inhibit t-PA release induced by platelet-activating factor (Paf-acether). 6 In vivo LTC4 and LTD4 (2 μg kg−1 i.v.) also induced an acute increase of t-PA activity in rat blood as evidenced by decreased blood clot lysis times. 7 Prostaglandin E1 and E2, prostacyclin and the stable prostacyclin analogue ZK 36374 at concentrations of 0.1–3.0 μmol l−1 induced little or no t-PA release." @default.
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- W2032889770 date "1988-01-01" @default.
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- W2032889770 title "Release of tissue-type plasminogen activator is induced in rats by leukotrienes C4 and D4, but not by prostaglandins E1, E2 and I2" @default.
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- W2032889770 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11417.x" @default.
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