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- W2032904605 abstract "We investigated several factors that could regulate the susceptibility of carcinoma cells to MAGE-2-specific CTL mediated lysis. Cytofluorometric analysis showed that the cytolysis correlated with the expression of CD54. IFN-gamma treatment induced the TAP-1 and LMP-2 genes, continuously up-regulated the HLA class I expression and increased cytolysis. Although HLA class I were highly induced in MRKnu1 cells, CD54 was not induced and the cytolysis was minimal. Cytotolysis of IFN-gamma-treated MKN-1 cells was completely inhibited by a monoclonal anti-CD54 antibody. These results suggest that HLA-restricted CTL lysis requires non-specific CD54 adherence receptors in addition to specific TCR signals." @default.
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- W2032904605 date "2000-10-01" @default.
- W2032904605 modified "2023-09-27" @default.
- W2032904605 title "MAGE-specific cytotoxic T lymphocytes require non-specific CD54 adherence receptors on carcinoma cells." @default.
- W2032904605 doi "https://doi.org/10.3892/ijo.17.4.805" @default.
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