FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032911488> ?p ?o ?g. }

• W2032911488 endingPage "9076" @default.
• W2032911488 startingPage "9071" @default.
• W2032911488 abstract "Hematopoietic stem cell (HSC) aging has become a concern in chemotherapy of older patients. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment (HM) control HSC activity during regenerative hematopoiesis. Connexin-43 (Cx43), a connexin constituent of gap junctions (GJs) is expressed in HSCs, down-regulated during differentiation, and postulated to be a self-renewal gene. Our studies, however, reveal that hematopoietic-specific Cx43 deficiency does not result in significant long-term competitive repopulation deficiency. Instead, hematopoietic Cx43 (H-Cx43) deficiency delays hematopoietic recovery after myeloablation with 5-fluorouracil (5-FU). 5-FU-treated H-Cx43-deficient HSC and progenitors (HSC/P) cells display decreased survival and fail to enter the cell cycle to proliferate. Cell cycle quiescence is associated with down-regulation of cyclin D1, up-regulation of the cyclin-dependent kinase inhibitors, p21 cip1. and p16 INK4a , and Forkhead transcriptional factor 1 (Foxo1), and activation of p38 mitogen-activated protein kinase (MAPK), indicating that H-Cx43-deficient HSCs are prone to senescence. The mechanism of increased senescence in H-Cx43-deficient HSC/P cells depends on their inability to transfer reactive oxygen species (ROS) to the HM, leading to accumulation of ROS within HSCs. In vivo antioxidant administration prevents the defective hematopoietic regeneration, as well as exogenous expression of Cx43 in HSC/P cells. Furthermore, ROS transfer from HSC/P cells to BM stromal cells is also rescued by reexpression of Cx43 in HSC/P. Finally, the deficiency of Cx43 in the HM phenocopies the hematopoietic defect in vivo. These results indicate that Cx43 exerts a protective role and regulates the HSC/P ROS content through ROS transfer to the HM, resulting in HSC protection during stress hematopoietic regeneration." @default.
• W2032911488 created "2016-06-24" @default.
• W2032911488 creator A5008810865 @default.
• W2032911488 creator A5014707733 @default.
• W2032911488 creator A5023053157 @default.
• W2032911488 creator A5036549437 @default.
• W2032911488 creator A5037991466 @default.
• W2032911488 creator A5043163926 @default.
• W2032911488 creator A5056576364 @default.
• W2032911488 creator A5069374229 @default.
• W2032911488 creator A5071636090 @default.
• W2032911488 creator A5072067867 @default.
• W2032911488 creator A5073333838 @default.
• W2032911488 date "2012-05-18" @default.
• W2032911488 modified "2023-09-30" @default.
• W2032911488 title "Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells" @default.
• W2032911488 cites W1596431542 @default.
• W2032911488 cites W1964457403 @default.
• W2032911488 cites W1983197681 @default.
• W2032911488 cites W1985801522 @default.
• W2032911488 cites W1991962444 @default.
• W2032911488 cites W1992811953 @default.
• W2032911488 cites W2001603811 @default.
• W2032911488 cites W2002426440 @default.
• W2032911488 cites W2004838336 @default.
• W2032911488 cites W2008484243 @default.
• W2032911488 cites W2010038916 @default.
• W2032911488 cites W2011059916 @default.
• W2032911488 cites W2012860082 @default.
• W2032911488 cites W2013702641 @default.
• W2032911488 cites W2028425461 @default.
• W2032911488 cites W2029027361 @default.
• W2032911488 cites W2038282968 @default.
• W2032911488 cites W2040595174 @default.
• W2032911488 cites W2040676119 @default.
• W2032911488 cites W2041134529 @default.
• W2032911488 cites W2045907249 @default.
• W2032911488 cites W2049157042 @default.
• W2032911488 cites W2051273609 @default.
• W2032911488 cites W2053169030 @default.
• W2032911488 cites W2069035576 @default.
• W2032911488 cites W2070154483 @default.
• W2032911488 cites W2076745831 @default.
• W2032911488 cites W2084289371 @default.
• W2032911488 cites W2093958228 @default.
• W2032911488 cites W2100063372 @default.
• W2032911488 cites W2109065151 @default.
• W2032911488 cites W2121966499 @default.
• W2032911488 cites W2123721927 @default.
• W2032911488 cites W2125908905 @default.
• W2032911488 cites W2128345338 @default.
• W2032911488 cites W2131958173 @default.
• W2032911488 cites W2134924448 @default.
• W2032911488 cites W2145612190 @default.
• W2032911488 cites W2147611167 @default.
• W2032911488 cites W2183315051 @default.
• W2032911488 cites W2291689896 @default.
• W2032911488 cites W2403875818 @default.
• W2032911488 cites W2462667466 @default.
• W2032911488 cites W4233902562 @default.
• W2032911488 doi "https://doi.org/10.1073/pnas.1120358109" @default.
• W2032911488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3384185" @default.
• W2032911488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22611193" @default.
• W2032911488 hasPublicationYear "2012" @default.
• W2032911488 type Work @default.
• W2032911488 sameAs 2032911488 @default.
• W2032911488 citedByCount "135" @default.
• W2032911488 countsByYear W20329114882012 @default.
• W2032911488 countsByYear W20329114882013 @default.
• W2032911488 countsByYear W20329114882014 @default.
• W2032911488 countsByYear W20329114882015 @default.
• W2032911488 countsByYear W20329114882016 @default.
• W2032911488 countsByYear W20329114882017 @default.
• W2032911488 countsByYear W20329114882018 @default.
• W2032911488 countsByYear W20329114882019 @default.
• W2032911488 countsByYear W20329114882020 @default.
• W2032911488 countsByYear W20329114882021 @default.
• W2032911488 countsByYear W20329114882022 @default.
• W2032911488 countsByYear W20329114882023 @default.
• W2032911488 crossrefType "journal-article" @default.
• W2032911488 hasAuthorship W2032911488A5008810865 @default.
• W2032911488 hasAuthorship W2032911488A5014707733 @default.
• W2032911488 hasAuthorship W2032911488A5023053157 @default.
• W2032911488 hasAuthorship W2032911488A5036549437 @default.
• W2032911488 hasAuthorship W2032911488A5037991466 @default.
• W2032911488 hasAuthorship W2032911488A5043163926 @default.
• W2032911488 hasAuthorship W2032911488A5056576364 @default.
• W2032911488 hasAuthorship W2032911488A5069374229 @default.
• W2032911488 hasAuthorship W2032911488A5071636090 @default.
• W2032911488 hasAuthorship W2032911488A5072067867 @default.
• W2032911488 hasAuthorship W2032911488A5073333838 @default.
• W2032911488 hasBestOaLocation W20329114881 @default.
• W2032911488 hasConcept C109159458 @default.
• W2032911488 hasConcept C16930146 @default.
• W2032911488 hasConcept C201750760 @default.
• W2032911488 hasConcept C203014093 @default.
• W2032911488 hasConcept C2778086970 @default.
• W2032911488 hasConcept C2780007613 @default.

• next