FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032912275> ?p ?o ?g. }

• W2032912275 abstract "Transforming growth factor β (TGFβ) is a pluripotent cytokine promoting epithelial cell plasticity during morphogenesis and tumour progression. TGFβ binding to type II and type I serine/threonine kinase receptors (TβRII and TβRI) causes activation of different intracellular signaling pathways. TβRI is associated with the ubiquitin ligase tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6). Here we show that TGFβ, via TRAF6, causes Lys63-linked polyubiquitination of TβRI, promoting cleavage of TβRI by TNF-alpha converting enzyme (TACE), in a PKCζ-dependent manner. The liberated intracellular domain (ICD) of TβRI associates with the transcriptional regulator p300 to activate genes involved in tumour cell invasiveness, such as Snail and MMP2. Moreover, TGFβ-induced invasion of cancer cells is TACE- and PKCζ- dependent and the TβRI ICD is localized in the nuclei of different kinds of tumour cells in tissue sections. Thus, our data reveal a specific role for TβRI in TGFβ mediated tumour invasion." @default.
• W2032912275 created "2016-06-24" @default.
• W2032912275 creator A5017994375 @default.
• W2032912275 creator A5025076356 @default.
• W2032912275 creator A5033931569 @default.
• W2032912275 creator A5038007567 @default.
• W2032912275 creator A5044123584 @default.
• W2032912275 creator A5046317472 @default.
• W2032912275 creator A5060491711 @default.
• W2032912275 creator A5078419954 @default.
• W2032912275 creator A5079058702 @default.
• W2032912275 creator A5081723350 @default.
• W2032912275 creator A5084535456 @default.
• W2032912275 creator A5090646213 @default.
• W2032912275 date "2011-05-31" @default.
• W2032912275 modified "2023-10-17" @default.
• W2032912275 title "TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer" @default.
• W2032912275 cites W1964081206 @default.
• W2032912275 cites W1970136142 @default.
• W2032912275 cites W1987408592 @default.
• W2032912275 cites W1991169956 @default.
• W2032912275 cites W1992028524 @default.
• W2032912275 cites W1999614450 @default.
• W2032912275 cites W2008869198 @default.
• W2032912275 cites W2016715162 @default.
• W2032912275 cites W2028749490 @default.
• W2032912275 cites W2037226238 @default.
• W2032912275 cites W2042808830 @default.
• W2032912275 cites W2050621375 @default.
• W2032912275 cites W2053382232 @default.
• W2032912275 cites W2059952781 @default.
• W2032912275 cites W2065646518 @default.
• W2032912275 cites W2076622937 @default.
• W2032912275 cites W2086710054 @default.
• W2032912275 cites W2119803309 @default.
• W2032912275 cites W2135757180 @default.
• W2032912275 cites W2136280424 @default.
• W2032912275 cites W2147276889 @default.
• W2032912275 cites W2148392040 @default.
• W2032912275 cites W2152452001 @default.
• W2032912275 cites W2153203105 @default.
• W2032912275 cites W2154658376 @default.
• W2032912275 cites W2166987747 @default.
• W2032912275 cites W4248259718 @default.
• W2032912275 doi "https://doi.org/10.1038/ncomms1332" @default.
• W2032912275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3113296" @default.
• W2032912275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21629263" @default.
• W2032912275 hasPublicationYear "2011" @default.
• W2032912275 type Work @default.
• W2032912275 sameAs 2032912275 @default.
• W2032912275 citedByCount "159" @default.
• W2032912275 countsByYear W20329122752012 @default.
• W2032912275 countsByYear W20329122752013 @default.
• W2032912275 countsByYear W20329122752014 @default.
• W2032912275 countsByYear W20329122752015 @default.
• W2032912275 countsByYear W20329122752016 @default.
• W2032912275 countsByYear W20329122752017 @default.
• W2032912275 countsByYear W20329122752018 @default.
• W2032912275 countsByYear W20329122752019 @default.
• W2032912275 countsByYear W20329122752020 @default.
• W2032912275 countsByYear W20329122752021 @default.
• W2032912275 countsByYear W20329122752022 @default.
• W2032912275 countsByYear W20329122752023 @default.
• W2032912275 crossrefType "journal-article" @default.
• W2032912275 hasAuthorship W2032912275A5017994375 @default.
• W2032912275 hasAuthorship W2032912275A5025076356 @default.
• W2032912275 hasAuthorship W2032912275A5033931569 @default.
• W2032912275 hasAuthorship W2032912275A5038007567 @default.
• W2032912275 hasAuthorship W2032912275A5044123584 @default.
• W2032912275 hasAuthorship W2032912275A5046317472 @default.
• W2032912275 hasAuthorship W2032912275A5060491711 @default.
• W2032912275 hasAuthorship W2032912275A5078419954 @default.
• W2032912275 hasAuthorship W2032912275A5079058702 @default.
• W2032912275 hasAuthorship W2032912275A5081723350 @default.
• W2032912275 hasAuthorship W2032912275A5084535456 @default.
• W2032912275 hasAuthorship W2032912275A5090646213 @default.
• W2032912275 hasBestOaLocation W20329122751 @default.
• W2032912275 hasConcept C104317684 @default.
• W2032912275 hasConcept C118131993 @default.
• W2032912275 hasConcept C134459356 @default.
• W2032912275 hasConcept C153911025 @default.
• W2032912275 hasConcept C170493617 @default.
• W2032912275 hasConcept C195794163 @default.
• W2032912275 hasConcept C25602115 @default.
• W2032912275 hasConcept C502942594 @default.
• W2032912275 hasConcept C55493867 @default.
• W2032912275 hasConcept C62478195 @default.
• W2032912275 hasConcept C79879829 @default.
• W2032912275 hasConcept C86803240 @default.
• W2032912275 hasConcept C95444343 @default.
• W2032912275 hasConceptScore W2032912275C104317684 @default.
• W2032912275 hasConceptScore W2032912275C118131993 @default.
• W2032912275 hasConceptScore W2032912275C134459356 @default.
• W2032912275 hasConceptScore W2032912275C153911025 @default.
• W2032912275 hasConceptScore W2032912275C170493617 @default.
• W2032912275 hasConceptScore W2032912275C195794163 @default.
• W2032912275 hasConceptScore W2032912275C25602115 @default.
• W2032912275 hasConceptScore W2032912275C502942594 @default.
• W2032912275 hasConceptScore W2032912275C55493867 @default.
• W2032912275 hasConceptScore W2032912275C62478195 @default.

• next